Results 1 to 10 of about 4,627 (104)
XCR1+ DCs Are Critical for T Cell-Mediated Immunotherapy of Chronic Viral Infections
Cell Reports, 2023 Summary: The contribution of cross-presenting XCR1+ dendritic cells (DCs) and SIRPα+ DCs in maintaining T cell function during exhaustion and immunotherapeutic interventions of chronic infections remains poorly characterized.
Mireia Pedragosa +2 more
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Development and Function of Chicken XCR1+ Conventional Dendritic Cells
Frontiers in Immunology, 2023 Conventional dendritic cells (cDCs) are antigen-presenting cells (APCs) that play a central role in linking innate and adaptive immunity. cDCs have been well described in a number of different mammalian species, but remain poorly characterised in the ...
Joni Macdonald
exaly +3 more sources
Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age [PDF]
Advanced ScienceTrophoblast–immune cell communication is crucial during pregnancy, with impairments linked to adverse outcomes. The accumulation of decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) in the third trimester is vital for fetal ...
Meiqi Chen +12 more
doaj +2 more sources
Frontiers in Immunology, 2012 Cross-presentation of antigen by dendritic cells (DCs) to CD8+ T cells is a fundamentally important mechanism in the defense against pathogens and tumors.
Annabell Bachem +2 more
exaly +3 more sources
Frontiers in Immunology, 2022 Recent studies have indicated the involvement of chemokine-C-motif ligand 1 (XCL1) in nociceptive transmission; however, the participation of its two receptors, canonical chemokine-C-motif receptor 1 (XCR1) and integrin alpha-9 (ITGA9), recently ...
Agata Ciechanowska +2 more
exaly +3 more sources
Frontiers in Immunology, 2012 Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of DC known to be involved in antigen cross-presentation.
Richard A Kroczek, Volker Henn
exaly +3 more sources
Frontiers in Immunology, 2014 In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function.
Annabell Bachem +2 more
exaly +3 more sources
Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis [PDF]
Frontiers in ImmunologyIntroductionMultiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system (CNS), in which various immune cells contribute to disease progression, yet the role of dendritic cells (DCs) remains incompletely understood ...
Xingyu Rong +6 more
doaj +2 more sources
TopBP1 orchestrates PU.1–IRF8 transcriptional programming of dendritic cell differentiation and Flt3L-driven tumor immunity [PDF]
Experimental and Molecular MedicineDNA topoisomerase II-binding protein 1 (TopBP1) plays a critical role in V(D)J recombination and DNA damage repair during B and T cell development. However, its role in the development of conventional dendritic cells (cDCs) remains unexplored.
Min-Suk Cha +8 more
doaj +2 more sources
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression [PDF]
eLifeAtherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions.
Tianhan Li +16 more
doaj +2 more sources