Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age [PDF]
Advanced ScienceTrophoblast–immune cell communication is crucial during pregnancy, with impairments linked to adverse outcomes. The accumulation of decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) in the third trimester is vital for fetal ...
Meiqi Chen +12 more
doaj +3 more sources
XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
Cell Reports, 2023 Summary: The contribution of cross-presenting XCR1+ dendritic cells (DCs) and SIRPα+ DCs in maintaining T cell function during exhaustion and immunotherapeutic interventions of chronic infections remains poorly characterized.
Domenjo-Vila Eva +2 more
exaly +3 more sources
Development and function of chicken XCR1+ conventional dendritic cells
Frontiers in Immunology, 2023 Conventional dendritic cells (cDCs) are antigen-presenting cells (APCs) that play a central role in linking innate and adaptive immunity. cDCs have been well described in a number of different mammalian species, but remain poorly characterised in the ...
Zhiguang Wu +2 more
exaly +3 more sources
Murine Intestinal Neonatal and Adult Dendritic Cell Subset Migration and Activation Characteristics in Response to Toll-Like Receptor Stimulation Through MyD88. [PDF]
Scand J ImmunolDespite their importance, dendritic cell subsets are not well characterised in neonates. We here provide fundamental information on the abundance and phenotype of small‐intestinal neonatal DCs and assess the role of MyD88 in neonatal and adult DC migration in response to several toll‐like receptor ligands.
Muleta KG +9 more
europepmc +2 more sources
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression [PDF]
eLifeAtherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions.
Tianhan Li +16 more
doaj +2 more sources
Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis [PDF]
Frontiers in ImmunologyIntroductionMultiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system (CNS), in which various immune cells contribute to disease progression, yet the role of dendritic cells (DCs) remains incompletely understood ...
Xingyu Rong +6 more
doaj +2 more sources
Frontiers in Immunology, 2012 Cross-presentation of antigen by dendritic cells (DCs) to CD8+ T cells is a fundamentally important mechanism in the defense against pathogens and tumors.
Annabell Bachem +2 more
exaly +3 more sources
Frontiers in Immunology, 2022 Recent studies have indicated the involvement of chemokine-C-motif ligand 1 (XCL1) in nociceptive transmission; however, the participation of its two receptors, canonical chemokine-C-motif receptor 1 (XCR1) and integrin alpha-9 (ITGA9), recently ...
Agata Ciechanowska +2 more
exaly +3 more sources
Frontiers in Immunology, 2012 Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of DC known to be involved in antigen cross-presentation.
Richard A. Kroczek, Volker eHenn
exaly +3 more sources
The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis [PDF]
JCI InsightType 1 diabetes (T1D) is precipitated by the autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans. Chemokines have been identified as major conductors of islet infiltration by autoaggressive leukocytes, including
Camilla Tondello +13 more
doaj +2 more sources