Results 41 to 50 of about 5,269 (176)

Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells

iScience, 2021
Summary: Successful immune responses rely on a regulated delivery of the right signals to the right cells at the right time. Here we show that natural killer (NK) and dendritic epidermal γδ T cells (DETCs) use similar mechanisms to spatiotemporally ...
Sonia Ghilas, Marc Ambrosini, Jean-Charles Cancel, Carine Brousse, Marion Massé, Hugues Lelouard, Marc Dalod, Karine Crozat   +7 more
doaj   +1 more source

Exposure to the Gram-Negative Bacteria Pseudomonas aeruginosa Influences the Lung Dendritic Cell Population Signature by Interfering With CD103 Expression

Frontiers in Cellular and Infection Microbiology, 2021
Lung dendritic cells (DCs) are divided into two major populations, which include CD103+XCR1+ cDC1s and CD11b+Sirpα+ cDC2s. The maintenance of their relative proportions is dynamic and lung inflammation, such as caused by exposure to lipopolysaccharide ...
Julyanne Brassard, Joanny Roy, Anne-Marie Lemay, Marie-Josée Beaulieu, Emilie Bernatchez, Marc Veillette, Caroline Duchaine, Marie-Renée Blanchet   +7 more
doaj   +1 more source

Rat cytomegalovirus-encoded γ-chemokine vXCL1 is a highly adapted, species-specific agonist for rat XCR1-positive dendritic cells

, 2020
Dendritic cells (DCs) expressing the chemokine receptor XCR1 are specialized in antigen cross-presentation to control infections with intracellular pathogens.
Bauer, Agnieszka, Madela, Julia, Gurka, Stephanie, Mages, Hans Werner, Voigt, Sebastian, Kroczek, Richard A., Rosenkilde, Mette M., Daugvilaite, Viktorija, Berg, Christian   +8 more
core   +1 more source

XCR1 is differentially expressed in brain metastatic human breast cancer.

, 2021
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans ...
Shahan Mamoor
core   +1 more source

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection

Frontiers in Immunology, 2022
Targeting antigen to conventional dendritic cells (cDCs) can improve antigen-specific immune responses and additionally be used to influence the polarization of the immune responses. However, the mechanisms by which this is achieved are less clear.
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Sonja Bobic, Sonja Bobic, Anna Lysén, Anna Lysén, Peter Csaba Huszthy, Peter Csaba Huszthy, Arnar Gudjonsson, Arnar Gudjonsson, Ranveig Braathen, Ranveig Braathen, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +16 more
doaj   +1 more source

Die Expression des Chemokinrezeptors XCR1 kennzeichnet kreuzpräsentierende dendritische Zellen der Maus und des Menschen [PDF]

, 2013
Bei der Kreuzpräsentation durch dendritische Zellen (DC) werden extrazelluläre Antigene in den MHC I-Präsentationsweg eingeschleust und CD8+ T-Zellen präsentiert. Bisher werden die kreuzpräsentierenden DC der Maus durch die Expression der Moleküle CD8 in
Bachem, Annabell
core   +1 more source

A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells

Frontiers in Immunology, 2018
The chemokine receptor XCR1 is known to be selectively expressed by cross-presenting dendritic cells (DCs), while its ligand XCL1/lymphotactin is mainly produced by activated CD8+ T cells and natural killer cells.
Kazuhiko Matsuo, Kosuke Kitahata, Fumika Kawabata, Momo Kamei, Yuta Hara, Shiki Takamura, Naoki Oiso, Akira Kawada, Osamu Yoshie, Osamu Yoshie, Takashi Nakayama   +10 more
doaj   +1 more source

Functional characterization of XCR1-positive dendritic cells in mouse and man

, 2012
Abbildungsverzeichnis VI Tabellenverzeichnis VII 1 Einleitung 1 1.1 Das adaptive Immunsystem 1 1.1.1 Antigenaufnahme und klassische Präsentation 1 1.1.2 Antigen-Kreuzpräsentation 3 1.2 Dendritische Zellen der Maus 4 1.2.1 Dendritische Zellen der ...
Güttler, Steffen
core   +1 more source

Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1 [PDF]

The Journal of Immunology, 2013
Abstract Dendritic cells (DCs) consist of various subsets that play crucial roles in linking innate and adaptive immunity. In the murine spleen, CD8α+ DCs exhibit a propensity to ingest dying/dead cells, produce proinflammatory cytokines, and cross-present Ags to generate CD8+ T cell responses.
Chihiro, Yamazaki, Masanaka, Sugiyama, Tomokazu, Ohta, Hiroaki, Hemmi, Eri, Hamada, Izumi, Sasaki, Yuri, Fukuda, Takahiro, Yano, Mikako, Nobuoka, Takeshi, Hirashima, Akihiko, Iizuka, Katsuaki, Sato, Takashi, Tanaka, Katsuaki, Hoshino, Tsuneyasu, Kaisho   +14 more
openaire   +2 more sources

Genetic variants associated with SARS-CoV-2 infection also affect lung function and asthma severity

Heliyon, 2023
Background: Host genetic factors may be associated with COVID-19 unfavourable outcomes. The first genome-wide association study (GWAS) conducted in individuals with respiratory failure due to COVID-19 revealed susceptibility loci close to six genes ...
Milca de Jesus Silva, Candace Machado de Andrade, Bianca Sampaio Dotto Fiuza, Gabriela Pimentel Pinheiro, Cínthia Vila Nova Santana, Ryan dos S. Costa, Kathleen Barnes, Álvaro A. Cruz, Camila Alexandrina Figueiredo   +8 more
doaj   +1 more source