Results 41 to 50 of about 7,168 (188)

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice [PDF]

, 2017
Significance Our studies indicate that the resident macrophages of the pancreatic islets of Langerhans have a seminal role in the initiation and progression of autoimmune diabetes in NOD mice.
Carrero, Javier A., Ferris, Stephen T., Hu, Hao, McCarthy, Derrick P., Unanue, Emil R., Vomund, Anthony N., Wan, Xiaoxiao, Zinselmeyer, Bernd H.   +7 more
core   +2 more sources

Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells In Vivo [PDF]

, 2018
Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells.
Keppler, SJ, Pakalniškytė, D, Papaioannou, NE, Pasztoi, M, Rambichler, S, Reis E Sousa, C, Rogers, NC, Salvermoser, J, Schraml, BU, Straub, T, Van Blijswijk, J   +10 more
core   +1 more source

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis [PDF]

Nature Medicine, 2021
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic necro-inflammation is a critical factor in development of NASH, yet the cellular and molecular mechanisms of immune dysregulation in this ...
Deczkowska, Aleksandra, David, Eyal, Ramadori, Pierluigi, Pfister, Dominik, Safran, Michael, At the, Baoguo, Giladi, Amir, Jaitin, Diego Adhemar, Barboy, Oren, Cohen, Merav, Yofe, Ido, Gur, Chamutal, Shlomi-Loubaton, Shir, Henri, Sandrine, Suhail, Yousuf, Qiu, Mengjie, Kam, Shing, Hermon, Hila, Lahat, Eylon, Ben Yakov, Gil, Cohen-Ezra, Oranit, Davidov, Yana, Likhter, Mariya, Goitein, David, Roth, Susanne, Weber, Achim, Malissen, Bernard, Weiner, Assaf, Ben-Ari, Ziv, Heikenwälder, Mathias, Elinav, Eran, Amit, Ido   +31 more
openaire   +4 more sources

Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells

iScience, 2021
Summary: Successful immune responses rely on a regulated delivery of the right signals to the right cells at the right time. Here we show that natural killer (NK) and dendritic epidermal γδ T cells (DETCs) use similar mechanisms to spatiotemporally ...
Sonia Ghilas, Marc Ambrosini, Jean-Charles Cancel, Carine Brousse, Marion Massé, Hugues Lelouard, Marc Dalod, Karine Crozat   +7 more
doaj   +1 more source

Exposure to the Gram-Negative Bacteria Pseudomonas aeruginosa Influences the Lung Dendritic Cell Population Signature by Interfering With CD103 Expression

Frontiers in Cellular and Infection Microbiology, 2021
Lung dendritic cells (DCs) are divided into two major populations, which include CD103+XCR1+ cDC1s and CD11b+Sirpα+ cDC2s. The maintenance of their relative proportions is dynamic and lung inflammation, such as caused by exposure to lipopolysaccharide ...
Julyanne Brassard, Joanny Roy, Anne-Marie Lemay, Marie-Josée Beaulieu, Emilie Bernatchez, Marc Veillette, Caroline Duchaine, Marie-Renée Blanchet   +7 more
doaj   +1 more source

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection

Frontiers in Immunology, 2022
Targeting antigen to conventional dendritic cells (cDCs) can improve antigen-specific immune responses and additionally be used to influence the polarization of the immune responses. However, the mechanisms by which this is achieved are less clear.
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Sonja Bobic, Sonja Bobic, Anna Lysén, Anna Lysén, Peter Csaba Huszthy, Peter Csaba Huszthy, Arnar Gudjonsson, Arnar Gudjonsson, Ranveig Braathen, Ranveig Braathen, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +16 more
doaj   +1 more source

Keeping a lid on nodal : transcriptional and translational repression of nodal signalling [PDF]

, 2016
Nodal is an evolutionarily conserved member of the transforming growth factor-β (TGF-β) superfamily of secreted signalling factors. Nodal factors are known to play key roles in embryonic development and asymmetry in a variety of organisms ranging from ...
Robertson, Elizabeth J., Sampath, Karuna
core   +1 more source

Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1 [PDF]

The Journal of Immunology, 2013
Abstract Dendritic cells (DCs) consist of various subsets that play crucial roles in linking innate and adaptive immunity. In the murine spleen, CD8α+ DCs exhibit a propensity to ingest dying/dead cells, produce proinflammatory cytokines, and cross-present Ags to generate CD8+ T cell responses.
Chihiro, Yamazaki, Masanaka, Sugiyama, Tomokazu, Ohta, Hiroaki, Hemmi, Eri, Hamada, Izumi, Sasaki, Yuri, Fukuda, Takahiro, Yano, Mikako, Nobuoka, Takeshi, Hirashima, Akihiko, Iizuka, Katsuaki, Sato, Takashi, Tanaka, Katsuaki, Hoshino, Tsuneyasu, Kaisho   +14 more
openaire   +2 more sources

Theory of the Spatio-Temporal Dynamics of Transport Bifurcations

, 1996
The development and time evolution of a transport barrier in a magnetically confined plasma with non-monotonic, nonlinear dependence of the anomalous flux on mean gradients is analyzed.
Burrell K. H., Lebedev V. B., P. H. Diamond, V. B. Lebedev   +3 more
core   +1 more source

The XCL1-XCR1 axis supports intestinal tissue residency and antitumor immunity. [PDF]

J Exp Med
Tissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated with improved clinical outcomes. However, the cellular interactions that program TRM differentiation and function are not well understood.
Ferry A, Mempel KM, Monell A, Reina-Campos M, Scharping NE, Heeg M, Takehara KK, Schokrpur S, Kuo N, Saddawi-Konefka R, Gutkind JS, Goldrath AW.   +11 more
europepmc   +4 more sources