Results 51 to 60 of about 672 (110)

Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes

Frontiers in Immunology, 2019
Vaccination strategy that induce efficient antibody responses polytopically in most lymph nodes (LNs) against infections has not been established yet.
Yusuke Kitazawa, Hisashi Ueta, Yasushi Sawanobori, Tomoya Katakai, Hiroyuki Yoneyama, Satoshi Ueha, Kouji Matsushima, Nobuko Tokuda, Kenjiro Matsuno   +8 more
doaj   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, Volume 13, Issue 52, 18 September 2026.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Rat cytomegalovirus-encoded γ-chemokine vXCL1 is a highly adapted, species-specific agonist for rat XCR1-positive dendritic cells

, 2020
Dendritic cells (DCs) expressing the chemokine receptor XCR1 are specialized in antigen cross-presentation to control infections with intracellular pathogens.
Bauer, Agnieszka, Madela, Julia, Gurka, Stephanie, Mages, Hans Werner, Voigt, Sebastian, Kroczek, Richard A., Rosenkilde, Mette M., Daugvilaite, Viktorija, Berg, Christian   +8 more
core   +1 more source

High‐dimensional spectral flow cytometry uncovers progressive T‐cell exhaustion and myeloid cell reprogramming in a CLL mouse model

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Chronic lymphocytic leukemia (CLL) exhibits marked clinical heterogeneity that cannot be fully explained by genetic alterations, underscoring the critical role of the tumor microenvironment in disease progression and therapeutic resistance.
Hannah Briesch, Mariana Coelho, Alessia Floerchinger, Yuliia Borysovych, Nicolas Aubert, Daniel Medina‐Gil, Manina Breitinger, Marc Zapatka, Stella E. Autenrieth, Martina Seiffert   +9 more
wiley   +1 more source

Basal Internalization and Subcellular Localization of XCR1

Chemokines orchestrate immune cell trafficking through receptor-mediated signaling and are implicated in inflammatory, autoimmune, and neuropathic disorders.
Li, Qiao, Salgado-Polo, Fernando, Pfersdorf, Fabian, Gustavsson, Martin   +3 more
core   +1 more source

Primers used for amplification cattle XCR1 and XCL1 genes.

, 2017
Primers used for amplification cattle XCR1 and XCL1 genes.
Xueqing Ma (3687436), Yingli Chen (383063), Zengjun Lu (313655), Huifang Bao (2221972), Xingwen Bai (313652), Zaixin Liu (313659), Yuanfang Fu (2221978), Dong Li (212687), Pinghua Li (173201), Pu Sun (313657), Guoyan Wei (3700651), Yimei Cao (313653), Jing Zhang (23775), Kun Li (277035)   +13 more
core   +1 more source

Integrative multi‐omics analysis prioritizes DPEP1 as a genetically supported candidate associated with skin cancer risk

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Flowchart of the study design outlining target identification, validation, and subsequent functional and translational characterization. Abstract Background Skin cancer (SC) is among the most prevalent malignancies, yet causal circulating proteins and tractable therapeutic targets remain poorly defined.
Fan Shen, Yongkai Yu, Zongfeng Liao, Liye Mao, Qianyun Wang, Wanju Wang, Yuanhui Liu, Ling Li   +7 more
wiley   +1 more source

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN

Frontiers in Immunology, 2019
Granzyme A (GzmA), together with perforin, are well-known for their cytotoxic activity against tumor or virus-infected cells. In addition to this cytotoxic function, GzmA stimulates several immune cell types and induces inflammation in the absence of ...
Kanako Shimizu, Satoru Yamasaki, Maki Sakurai, Noriko Yumoto, Mariko Ikeda, Chiemi Mishima-Tsumagari, Mutsuko Kukimoto-Niino, Takashi Watanabe, Masami Kawamura, Mikako Shirouzu, Shin-ichiro Fujii   +10 more
doaj   +1 more source

Endothelial Atypical Receptors for Chemoattractants in Lung Immune Surveillance

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Control of chemokine gradients within tissues is achieved by atypical chemokine receptors (ACKRs). The lungs require tightly regulated leukocyte recruitment for effective host defense while preventing tissue damage. In this context, ACKRs expressed by lung endothelial cells are emerging as critical regulators of leukocyte trafficking and inflammatory ...
Mattia Laffranchi, Eleonora Bonanni, Francesca Sozio, Miriam Turchetti, Giuseppe Sciumè, Marcus Thelen, Annalisa Del Prete, Raffaella Bonecchi, Silvano Sozzani   +8 more
wiley   +1 more source