Results 51 to 60 of about 5,269 (176)

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Primers used for amplification cattle XCR1 and XCL1 genes.

, 2017
Primers used for amplification cattle XCR1 and XCL1 genes.
Xueqing Ma (3687436), Yingli Chen (383063), Zengjun Lu (313655), Huifang Bao (2221972), Xingwen Bai (313652), Zaixin Liu (313659), Yuanfang Fu (2221978), Dong Li (212687), Pinghua Li (173201), Pu Sun (313657), Guoyan Wei (3700651), Yimei Cao (313653), Jing Zhang (23775), Kun Li (277035)   +13 more
core   +1 more source

Immunotherapy of chronic virus infections : Exhausted CD8+ T cell subsets are differentially regulated by XCR1 + DC [PDF]

, 2022
The contribution of cross-presenting XCR1+ dendritic cells (DC) in maintaining T cell function during exhaustion and immuno-therapeutic interventions of chronic infections remains poorly characterized.
Domenjó Vila, Eva
core   +1 more source

Evolution of CAR‐T Therapy: Functional Engineering, Manufacturing Innovation, and Future In Vivo Strategies

Cancer Science, EarlyView.
CAR‐T therapy is evolving across four interconnected dimensions: functional engineering, manufacturing innovation, alternative cell sources, and in vivo CAR programming. Together, these advances address limitations in therapeutic efficacy, safety, manufacturing complexity, scalability, and accessibility, providing complementary paths toward the next ...
Yukimi Sakoda
wiley   +1 more source

Spatial transcriptomics reveals club cell features and strong CLDN18 expression along the mucinous pathway to invasive mucinous adenocarcinoma

The Journal of Pathology, Volume 270, Issue 4, Page 497-506, December 2026.
Abstract Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct subtype of lung adenocarcinoma with unique clinicopathologic features; however, its histogenesis remains incompletely understood. Although mucinous metaplasia has been suspected as a precursor lesion, direct molecular evidence supporting this progression is limited. In this study,
Joon Young Park, Do Yeon Kim, Hyun Jung Lee, Jung Hee Lee, Hae Ryoun Park, Dong Hoon Shin   +5 more
wiley   +1 more source

Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control

Frontiers in Immunology, 2019
Cross-presenting Xcr1+CD8α DCs are attractive APCs to target for therapeutic cancer vaccines, as they are able to take up and process antigen from dying tumor cells for their MHCI-restricted presentation to CD8 T cells.
Natalia K. Botelho, Benjamin O. Tschumi, Jeffrey A. Hubbell, Melody A. Swartz, Melody A. Swartz, Alena Donda, Pedro Romero   +6 more
doaj   +1 more source

ITGAM+ Extracellular Vesicles Trigger CD8+ T Cell Activation via S100a9‐Mediated Metabolic Reprogramming in Acute Kidney Injury

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
ABSTRACT Acute kidney injury (AKI) is a prevalent condition with limited therapeutic options, in which sustained renal injury driven by inflammation remains a central pathological challenge. Here, we identify a specific subset of extracellular vesicles (EVs) as the critical link translating early myeloid inflammation into metabolically fuelled CD8+ T ...
Yu‐Qi Fu, Yi‐Lin Zhang, An‐Ran Shen, Ning Li, Jing Song, Yan Bao, Si‐Meng Wang, Ding‐Ding Xue, Min Wu, Bin Wang, Yi Wen, Tao‐Tao Tang, Lin‐Li Lv, Bi‐Cheng Liu   +13 more
wiley   +1 more source

Endocytosis Deficient Murine Xcl1-Fusion Vaccine Enhances Protective Antibody Responses in Mice

Frontiers in Immunology, 2019
Targeting antigen to surface receptors on dendritic cells (DCs) can improve antibody response against subunit vaccines. We have previously observed that human XCL1-fusion vaccines target murine Xcr1+ DCs without actively inducing endocytosis of the ...
Arnar Gudjonsson, Tor Kristian Andersen, Vibeke Sundvold-Gjerstad, Bjarne Bogen, Bjarne Bogen, Even Fossum   +5 more
doaj   +1 more source

Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterisation of avian conventional dendritic cells [PDF]

, 2021
Conventional dendritic cells (cDC) are bone marrow derived immune cells that play a central role in linking innate and adaptive immunity. cDCs efficiently uptake, process, and present antigen to naïve T cells, driving clonal expansion of antigen specific
Stevens, Mark P, Joni Macdonald, Kaiser, Pete, David A. Hume, Balic, Adam, Zhiguang Wu, Wu, Zhiguang, Sang, Helen, Macdonald, Joni, Pete Kaiser, Mark P. Stevens, Adam Balic, Helen Sang, Hume, David A, Cosmin Chintoan‐Uta, Hu, Tuanjun, Tuanjun Hu, Chintoan-Uta, Cosmin   +17 more
core   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, Volume 13, Issue 57, 14 October 2026.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source