Results 31 to 40 of about 4,391 (150)

Expression of XCR1 characterizes the Batf3-dependent lineage of dendritic cells capable of antigen cross-presentation

Frontiers in Immunology, 2012
Cross-presentation of antigen by dendritic cells (DCs) to CD8+ T cells is a fundamentally important mechanism in the defense against pathogens and tumors.
Annabell eBachem, Evelyn eHartung, Steffen eGüttler, Ahmed eMora, Xuefei eZhou, Anika eHegemann, Maud ePlantinga, Elisa eMazzini, Patrizia eStoitzner, Stephanie eGurka, Volker eHenn, Hans W Mages, Richard A. Kroczek   +12 more
doaj   +1 more source

Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells

iScience, 2021
Summary: Successful immune responses rely on a regulated delivery of the right signals to the right cells at the right time. Here we show that natural killer (NK) and dendritic epidermal γδ T cells (DETCs) use similar mechanisms to spatiotemporally ...
Sonia Ghilas, Marc Ambrosini, Jean-Charles Cancel, Carine Brousse, Marion Massé, Hugues Lelouard, Marc Dalod, Karine Crozat   +7 more
doaj   +1 more source

Exposure to the Gram-Negative Bacteria Pseudomonas aeruginosa Influences the Lung Dendritic Cell Population Signature by Interfering With CD103 Expression

Frontiers in Cellular and Infection Microbiology, 2021
Lung dendritic cells (DCs) are divided into two major populations, which include CD103+XCR1+ cDC1s and CD11b+Sirpα+ cDC2s. The maintenance of their relative proportions is dynamic and lung inflammation, such as caused by exposure to lipopolysaccharide ...
Julyanne Brassard, Joanny Roy, Anne-Marie Lemay, Marie-Josée Beaulieu, Emilie Bernatchez, Marc Veillette, Caroline Duchaine, Marie-Renée Blanchet   +7 more
doaj   +1 more source

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection

Frontiers in Immunology, 2022
Targeting antigen to conventional dendritic cells (cDCs) can improve antigen-specific immune responses and additionally be used to influence the polarization of the immune responses. However, the mechanisms by which this is achieved are less clear.
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Sonja Bobic, Sonja Bobic, Anna Lysén, Anna Lysén, Peter Csaba Huszthy, Peter Csaba Huszthy, Arnar Gudjonsson, Arnar Gudjonsson, Ranveig Braathen, Ranveig Braathen, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +16 more
doaj   +1 more source

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis [PDF]

Nature Medicine, 2021
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic necro-inflammation is a critical factor in development of NASH, yet the cellular and molecular mechanisms of immune dysregulation in this ...
Deczkowska, Aleksandra, David, Eyal, Ramadori, Pierluigi, Pfister, Dominik, Safran, Michael, At the, Baoguo, Giladi, Amir, Jaitin, Diego Adhemar, Barboy, Oren, Cohen, Merav, Yofe, Ido, Gur, Chamutal, Shlomi-Loubaton, Shir, Henri, Sandrine, Suhail, Yousuf, Qiu, Mengjie, Kam, Shing, Hermon, Hila, Lahat, Eylon, Ben Yakov, Gil, Cohen-Ezra, Oranit, Davidov, Yana, Likhter, Mariya, Goitein, David, Roth, Susanne, Weber, Achim, Malissen, Bernard, Weiner, Assaf, Ben-Ari, Ziv, Heikenwälder, Mathias, Elinav, Eran, Amit, Ido   +31 more
openaire   +4 more sources

A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells

Frontiers in Immunology, 2018
The chemokine receptor XCR1 is known to be selectively expressed by cross-presenting dendritic cells (DCs), while its ligand XCL1/lymphotactin is mainly produced by activated CD8+ T cells and natural killer cells.
Kazuhiko Matsuo, Kosuke Kitahata, Fumika Kawabata, Momo Kamei, Yuta Hara, Shiki Takamura, Naoki Oiso, Akira Kawada, Osamu Yoshie, Osamu Yoshie, Takashi Nakayama   +10 more
doaj   +1 more source

Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1 [PDF]

The Journal of Immunology, 2013
Abstract Dendritic cells (DCs) consist of various subsets that play crucial roles in linking innate and adaptive immunity. In the murine spleen, CD8α+ DCs exhibit a propensity to ingest dying/dead cells, produce proinflammatory cytokines, and cross-present Ags to generate CD8+ T cell responses.
Chihiro, Yamazaki, Masanaka, Sugiyama, Tomokazu, Ohta, Hiroaki, Hemmi, Eri, Hamada, Izumi, Sasaki, Yuri, Fukuda, Takahiro, Yano, Mikako, Nobuoka, Takeshi, Hirashima, Akihiko, Iizuka, Katsuaki, Sato, Takashi, Tanaka, Katsuaki, Hoshino, Tsuneyasu, Kaisho   +14 more
openaire   +2 more sources

Genetic variants associated with SARS-CoV-2 infection also affect lung function and asthma severity

Heliyon, 2023
Background: Host genetic factors may be associated with COVID-19 unfavourable outcomes. The first genome-wide association study (GWAS) conducted in individuals with respiratory failure due to COVID-19 revealed susceptibility loci close to six genes ...
Milca de Jesus Silva, Candace Machado de Andrade, Bianca Sampaio Dotto Fiuza, Gabriela Pimentel Pinheiro, Cínthia Vila Nova Santana, Ryan dos S. Costa, Kathleen Barnes, Álvaro A. Cruz, Camila Alexandrina Figueiredo   +8 more
doaj   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Tolerogenic XCR1+ dendritic cell population is dysregulated in HLA-B27 transgenic rat model of spondyloarthritis

Arthritis Research & Therapy, 2019
Background Spondyloarthritis (SpA) is a chronic inflammatory disease affecting primarily axial and peripheral joints and sometimes also extra-articular organs, such as the gut.
Kétia Ermoza, Simon Glatigny, Nadège Jah, Vânia Camilo, Hendrick Mambu Mambueni, Luiza M. Araujo, Gilles Chiocchia, Maxime Breban   +7 more
doaj   +1 more source