Results 31 to 40 of about 7,168 (188)

Cross-Presenting XCR1+ Dendritic Cells as Targets for Cancer Immunotherapy [PDF]

Cells, 2020
The use of dendritic cells (DCs) to generate effective anti-tumor T cell immunity has garnered much attention over the last thirty-plus years. Despite this, limited clinical benefit has been demonstrated thus far. There has been a revival of interest in DC-based treatment strategies following the remarkable patient responses observed with novel ...
Katherine M. Audsley, Alison M. McDonnell, Jason Waithman   +2 more
openaire   +3 more sources

Novel approaches to increase resistance to acute respiratory infections

RUDN Journal of Medicine, 2021
Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize
Svetlana V. Guryanova, Natalia A. Kudryashova, Anastasiya A. Kataeva, Bubusaira T. Orozbekova, Natalia V. Kolesnikova, Alexandr G. Chuchalin   +5 more
doaj   +1 more source

Cross-presentation of cutaneous melanoma antigen by migratory XCR1⁺CD103⁻and XCR1⁺CD103⁺dendritic cells [PDF]

OncoImmunology, 2015
The question of which dendritic cells (DCs) cross-present peripheral tumor antigens remains unanswered. We assessed the ability of multiple skin-derived and lymphoid resident DCs to perform this function in a novel orthotopic murine melanoma model where tumor establishment and expansion is within the skin.
Ben, Wylie, Elke, Seppanen, Kun, Xiao, Rachael, Zemek, Damien, Zanker, Sandro, Prato, Bree, Foley, Prue H, Hart, Richard A, Kroczek, Weisan, Chen, Jason, Waithman   +10 more
openaire   +2 more sources

Myocardial infarction primes autoreactive T cells through activation of dendritic cells [PDF]

, 2017
Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An example
Bouché, Ann, Carmeliet, Peter, De Prijck, Sofie, Gillebert, Thierry, Guilliams, Martin, Lambrecht, Bart, Ludewig, Burkhard, Martens, Liesbet, Nindl, Veronika, Saeys, Yvan, Scott, Charlotte, Sichien, Dorine, Van Der Borght, Katrien, Van Moorleghem, Justine, Vanheerswynghels, Manon   +14 more
core   +12 more sources

Spatially Restricted Translation of the xCR1 mRNA in Xenopus Embryos [PDF]

Molecular and Cellular Biology, 2009
The xCR1 protein is a maternal determinant and cofactor for nodal signaling in vertebrate embryos. The xCR1 protein accumulates specifically in the animal cells of Xenopus embryos, but maternal xCR1 mRNA is distributed equally throughout all embryonic cells.
Zhang, Yan, Forinash, Kara D., McGivern, Jered, Fritz, Brian, Dorey, Karel; id_orcid 0000-0003-0846-5286, Sheets, Michael D.   +5 more
openaire   +3 more sources

Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile

Frontiers in Immunology, 2023
Dendritic cells (DC) play a crucial role in generating and maintaining antiviral immunity. While DC are implicated in the antiviral defense by inducing T cell responses, they can also become infected by Cytomegalovirus (CMV).
Julia Cecilia Madela-Mönchinger, Silver Anthony Wolf, Emanuel Wyler, Agnieszka Bauer, Marius Mischke, Lars Möller, Vanda Juranić Lisnić, Markus Landthaler, Anna Malyshkina, Sebastian Voigt   +9 more
doaj   +1 more source

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2 [PDF]

, 2016
Plasmacytoid dendritic cells (DCs [pDCs]) develop from pre-pDCs, whereas two lineages of conventional DCs (cDCs; cDC1s and cDC2s) develop from lineage-committed pre-cDCs.
Bachem, Bajaña, Bart N. Lambrecht, Bieke Soen, Broos, Broos, Caton, Cerovic, Charlotte L. Scott, Cisse, Danny Huylebroeck, De Craene, Denecker, Dominguez, Edelson, Geert Berx, Gert Van Isterdael, Ghosh, Gillian Blancke, Goossens, Grajales-Reyes, Greter, Guilliams, Hacker, Haniffa, Hegarty, Helft, Higashi, Hildner, Jackson, Joachim Taminau, Jody Haigh, Kashiwada, Lewis, Li, Liesbet Martens, Liu, Martin Guilliams, Merad, Miller, Murphy, Naik, Nicolas Skrypek, Omilusik, Onai, Persson, Persson, Remacle, Satpathy, Schlitzer, Schlitzer, Scott, Scott, Spits, Swiecki, Tailor, Tamura, Tatari, Tussiwand, van Helden, Welty, Williams, Wouter Saelens, Wu, Yvan Saeys   +64 more
core   +2 more sources

Identification of Single C Motif-1/Lymphotactin Receptor XCR1 [PDF]

Journal of Biological Chemistry, 1998
Single C motif-1 (SCM-1)/lymphotactin is a member of the chemokine superfamily, but retains only the 2nd and 4th of the four cysteine residues conserved in other chemokines. In humans, there are two highly homologous SCM-1 genes encoding SCM-1alpha and SCM-1beta with two amino acid substitutions.
T, Yoshida, T, Imai, M, Kakizaki, M, Nishimura, S, Takagi, O, Yoshie   +5 more
openaire   +2 more sources

The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine. [PDF]

PLoS ONE, 2017
The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and XCL1 and their distribution among peripheral blood ...
Kun Li, Guoyan Wei, Yimei Cao, Dong Li, Pinghua Li, Jing Zhang, Huifang Bao, Yingli Chen, Yuanfang Fu, Pu Sun, Xingwen Bai, Xueqing Ma, Zengjun Lu, Zaixin Liu   +13 more
doaj   +1 more source

Dendritic cell subsets in the intestinal lamina propria: ontogeny and function [PDF]

, 2013
The intestinal mucosa is exposed to large amounts of foreign antigen (Ag) derived from commensal bacteria, dietary Ags, and intestinal pathogens. Dendritic cells (DCs) are believed to be involved in the induction of tolerance to harmless Ags and in ...
Agace, Agace, Agace, Aliberti, Anjuere, Annacker, Bachem, Bachem, Bain, Banchereau, Bedoui, Bogunovic, Carter, Cebula, Cerovic, Chervonsky, Coombes, Crozat, Cruickshank, del Rio, del Rio, Denning, Diehl, Edelson, Edelson, Farache, Forster, Fujimoto, Ginhoux, Greter, Hadis, Halle, Hammerschmidt, Haniffa, Hildner, Hoshi, Ichikawa, Iwata, Jackson, Jaensson, Jaensson-Gyllenback, Jang, Johansson-Lindbom, Johansson-Lindbom, Jones, Jongbloed, Kinnebrew, Kobayashi, Kusunoki, Lewis, Liu, Macpherson, Maynard, McDole, Merad, Miller, Milling, Molenaar, Mucida, Naik, Naik, Niess, Onai, Persson, Poulin, Poulin, Rescigno, Rivollier, Sathaliyawala, Schlitzer, Schulz, Scott, Siddiqui, Sun, Svensson, Tamoutounour, Travis, Uematsu, Uematsu, Vallon-Eberhard, Varol, Vremec, Weiss, Worbs, Wu, Zeng, Zhan, Zigmond   +87 more
core   +1 more source