Results 31 to 40 of about 5,269 (176)

Overexpression of chemokine receptor lymphotactin receptor 1 has prognostic value in clear cell renal cell carcinoma

Molecular Genetics & Genomic Medicine, 2021
Background Clear cell renal cell carcinoma (ccRCC) is an aggressive subtype of renal cell carcinoma. X‐C motif chemokine receptor 1 (XCR1) exerts important roles in tumor progression; however, its role in ccRCC is unclear.
Xian Chang, Ya Cao, Wan‐Lei Fu, Xue‐Feng Tang, Ya‐Li Wang, Yang‐Fan Lv, Qiao‐Nan Guo   +6 more
doaj   +1 more source

Up-regulation of XCR1 expression in rheumatoid joints [PDF]

Rheumatology, 2004
Chemokine receptor-positive cells play a crucial role in controlling synovitis in rheumatoid arthritis (RA). We studied 16 chemokine receptors of the CC, CXC, CX3C and C families by analysing venous blood and synovial fluid samples and synovial tissues from RA patients.Mononuclear cells (MNCs) in paired synovial fluid and venous blood samples from 7 RA
C-R, Wang, M-F, Liu, Y-H, Huang, H-C, Chen   +3 more
openaire   +2 more sources

Novel approaches to increase resistance to acute respiratory infections

RUDN Journal of Medicine, 2021
Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize
Svetlana V. Guryanova, Natalia A. Kudryashova, Anastasiya A. Kataeva, Bubusaira T. Orozbekova, Natalia V. Kolesnikova, Alexandr G. Chuchalin   +5 more
doaj   +1 more source

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis [PDF]

Scientific Reports, 2016
Abstract Intestinal immune homeostasis requires dynamic crosstalk between innate and adaptive immune cells. Dendritic cells (DCs) exist as multiple phenotypically and functionally distinct sub-populations within tissues, where they initiate immune responses and promote homeostasis. In the gut, there exists a minor
Ohta, T, Sugiyama, M, Hemmi, H, Yamazaki, C, Okura, S, Sasaki, I, Fukuda, Y, Orimo, T, Ishii, K.J, Hoshino, K, Ginhoux, F, Kaisho, T   +11 more
openaire   +2 more sources

Harnessing human cross-presenting CLEC9A+XCR1+ dendritic cells for immunotherapy [PDF]

Frontiers in Immunology, 2014
Dendritic cells (DC) are professional antigen presenting cells (APCs) that play a pivotal role in the induction and regulation of immune responses, including the induction of cytotoxic T lymphocyte (CTL) responses. They are an important focus for the development of vaccines against cancers and many pathogens, including HIV and malaria, where CTL ...
Kirsteen eTullett, Kirsteen eTullett, Kirsteen eTullett, Mireille eLahoud, Mireille eLahoud, Kristen J Radford, Kristen J Radford   +6 more
doaj   +6 more sources

Cross-Presenting XCR1+ Dendritic Cells as Targets for Cancer Immunotherapy [PDF]

Cells, 2020
The use of dendritic cells (DCs) to generate effective anti-tumor T cell immunity has garnered much attention over the last thirty-plus years. Despite this, limited clinical benefit has been demonstrated thus far. There has been a revival of interest in DC-based treatment strategies following the remarkable patient responses observed with novel ...
Katherine M. Audsley, Alison M. McDonnell, Jason Waithman   +2 more
openaire   +3 more sources

Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile

Frontiers in Immunology, 2023
Dendritic cells (DC) play a crucial role in generating and maintaining antiviral immunity. While DC are implicated in the antiviral defense by inducing T cell responses, they can also become infected by Cytomegalovirus (CMV).
Julia Cecilia Madela-Mönchinger, Silver Anthony Wolf, Emanuel Wyler, Agnieszka Bauer, Marius Mischke, Lars Möller, Vanda Juranić Lisnić, Markus Landthaler, Anna Malyshkina, Sebastian Voigt   +9 more
doaj   +1 more source

Cross-presentation of cutaneous melanoma antigen by migratory XCR1⁺CD103⁻and XCR1⁺CD103⁺dendritic cells [PDF]

OncoImmunology, 2015
The question of which dendritic cells (DCs) cross-present peripheral tumor antigens remains unanswered. We assessed the ability of multiple skin-derived and lymphoid resident DCs to perform this function in a novel orthotopic murine melanoma model where tumor establishment and expansion is within the skin.
Ben, Wylie, Elke, Seppanen, Kun, Xiao, Rachael, Zemek, Damien, Zanker, Sandro, Prato, Bree, Foley, Prue H, Hart, Richard A, Kroczek, Weisan, Chen, Jason, Waithman   +10 more
openaire   +2 more sources

Cancer cells prevent the differentiation of bone marrow precursors into CD103⁺XCR1⁺ DC1s.

, 2021
(A-C) FLT3L-BMDCs were exposed to GM-CSF ± live B16F10/LLC cells or a B16F10/LLC antigenic preparation (A and B). In C), DCs were segregated (or not) from cancer cells with a 0.4 μm insert.
Julyanne Brassard (4117441), David Marsolais (346229), Meredith Elizabeth Gill (11772745), Emilie Bernatchez (4117435), Véronique Desjardins (11772748), Marie-Renée Blanchet (4117438), Philippe Joubert (245361), Joanny Roy (11083635)   +7 more
core   +1 more source

Identification of Single C Motif-1/Lymphotactin Receptor XCR1 [PDF]

Journal of Biological Chemistry, 1998
Single C motif-1 (SCM-1)/lymphotactin is a member of the chemokine superfamily, but retains only the 2nd and 4th of the four cysteine residues conserved in other chemokines. In humans, there are two highly homologous SCM-1 genes encoding SCM-1alpha and SCM-1beta with two amino acid substitutions.
T, Yoshida, T, Imai, M, Kakizaki, M, Nishimura, S, Takagi, O, Yoshie   +5 more
openaire   +2 more sources