Results 11 to 20 of about 4,391 (150)

Development and function of chicken XCR1+ conventional dendritic cells

Frontiers in Immunology, 2023
Conventional dendritic cells (cDCs) are antigen-presenting cells (APCs) that play a central role in linking innate and adaptive immunity. cDCs have been well described in a number of different mammalian species, but remain poorly characterised in the ...
Zhiguang Wu, Barbara Shih, Barbara Shih, Joni Macdonald, Dominique Meunier, Kris Hogan, Cosmin Chintoan-Uta, Hazel Gilhooley, Tuanjun Hu, Mariana Beltran, Neil C. Henderson, Neil C. Henderson, Helen M. Sang, Mark P. Stevens, Michael J. McGrew, Adam Balic, Adam Balic   +16 more
doaj   +4 more sources

Ontogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα [PDF]

Frontiers in Immunology, 2014
In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function.
Martina eBecker, Steffen eGüttler, Annabell eBachem, Evelyn eHartung, Ahmed eMora, Anika eJäkel, Andreas eHutloff, Volker eHenn, Hans Werner Mages, Stephanie eGurka, Richard A. Kroczek   +10 more
doaj   +5 more sources

The role of the chemokine receptor XCR1 in breast cancer cells

Breast Cancer: Targets and Therapy, 2017
Xiao Li Yang,1,* Li Guo Qi,2,* Feng Juan Lin,1 Zhou Luo Ou1 1Department of Oncology, Breast Cancer Institute, Fudan University, Shanghai Cancer Center, Shanghai, 2Department of Neurosurgery, Taian City Central Hospital, Taian, Shangdong, People’s ...
Yang XL, Qi LG, Lin FJ, Ou ZL
doaj   +6 more sources

PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis [PDF]

Nature Communications, 2021
Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell ...
Thais G. Moreira, Davide Mangani, Laura M. Cox, Jeffrey Leibowitz, Eduardo. L. C. Lobo, Mariana A. Oliveira, Christian D. Gauthier, Brenda N. Nakagaki, Valerie Willocq, Anya Song, Lydia Guo, David C. A. Lima, Gopal Murugaiyan, Oleg Butovsky, Galina Gabriely, Ana C. Anderson, Rafael M. Rezende, Ana Maria C. Faria, Howard L. Weiner   +18 more
doaj   +3 more sources

The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin [PDF]

Scientific Reports, 2017
XCR1 is selectively expressed on a conventional dendritic cell subset, the cDC1 subset, through phylogenetically distant species. The outcome of antigen-targeting to XCR1 may therefore be similar across species, permitting the translation of results from
Charlotte Deloizy, Even Fossum, Christophe Barnier-Quer, Céline Urien, Tiphany Chrun, Audrey Duval, Maelle Codjovi, Edwige Bouguyon, Pauline Maisonnasse, Pierre-Louis Hervé, Céline Barc, Olivier Boulesteix, Jérémy Pezant, Christophe Chevalier, Nicolas Collin, Marc Dalod, Bjarne Bogen, Nicolas Bertho, Isabelle Schwartz-Cornil   +18 more
doaj   +8 more sources

The role of XCR1 and its ligand XCL1 in antigen cross-presentation by murine and human dendritic cells [PDF]

Frontiers in Immunology, 2012
Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of DC known to be involved in antigen cross-presentation.
Richard A. Kroczek, Volker eHenn
doaj   +4 more sources

Structure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1+ Dendritic Cells [PDF]

Frontiers in Immunology, 2018
XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on cross-presenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of peptides or proteins into these DC.
Arthur L. Kroczek, Arthur L. Kroczek, Arthur L. Kroczek, Evelyn Hartung, Stephanie Gurka, Martina Becker, Nele Reeg, Hans W. Mages, Sebastian Voigt, Christian Freund, Richard A. Kroczek   +10 more
doaj   +5 more sources

Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells

Frontiers in Immunology, 2023
A single population of interferon-regulatory factor 8 (Irf8)-dependent conventional dendritic cell (cDC type1) is considered to be responsible for both immunogenic and tolerogenic responses depending on the surrounding cytokine milieu. Here, we challenge
Adan Chari Jirmo, Adan Chari Jirmo, Ruth Grychtol, Ruth Grychtol, Svenja Gaedcke, Bin Liu, Stephanie DeStefano, Christine Happle, Christine Happle, Olga Halle, Olga Halle, Joao T. Monteiro, Joao T. Monteiro, Anika Habener, Anika Habener, Oliver D. Breiholz, David DeLuca, Gesine Hansen, Gesine Hansen, Gesine Hansen   +19 more
doaj   +1 more source

Overexpression of chemokine receptor lymphotactin receptor 1 has prognostic value in clear cell renal cell carcinoma

Molecular Genetics & Genomic Medicine, 2021
Background Clear cell renal cell carcinoma (ccRCC) is an aggressive subtype of renal cell carcinoma. X‐C motif chemokine receptor 1 (XCR1) exerts important roles in tumor progression; however, its role in ccRCC is unclear.
Xian Chang, Ya Cao, Wan‐Lei Fu, Xue‐Feng Tang, Ya‐Li Wang, Yang‐Fan Lv, Qiao‐Nan Guo   +6 more
doaj   +1 more source

Up-regulation of XCR1 expression in rheumatoid joints [PDF]

Rheumatology, 2004
Chemokine receptor-positive cells play a crucial role in controlling synovitis in rheumatoid arthritis (RA). We studied 16 chemokine receptors of the CC, CXC, CX3C and C families by analysing venous blood and synovial fluid samples and synovial tissues from RA patients.Mononuclear cells (MNCs) in paired synovial fluid and venous blood samples from 7 RA
C-R, Wang, M-F, Liu, Y-H, Huang, H-C, Chen   +3 more
openaire   +2 more sources