Ontogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα [PDF]
Frontiers in Immunology, 2014 In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function.
Martina eBecker +10 more
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The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin
Scientific Reports, 2017 XCR1 is selectively expressed on a conventional dendritic cell subset, the cDC1 subset, through phylogenetically distant species. The outcome of antigen-targeting to XCR1 may therefore be similar across species, permitting the translation of results from
Charlotte Deloizy +18 more
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The role of the chemokine receptor XCR1 in breast cancer cells
Breast Cancer: Targets and Therapy, 2017 Xiao Li Yang,1,* Li Guo Qi,2,* Feng Juan Lin,1 Zhou Luo Ou1 1Department of Oncology, Breast Cancer Institute, Fudan University, Shanghai Cancer Center, Shanghai, 2Department of Neurosurgery, Taian City Central Hospital, Taian, Shangdong, People’s ...
Yang XL, Qi LG, Lin FJ, Ou ZL
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The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine. [PDF]
PLoS ONE, 2017 The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and XCL1 and their distribution among peripheral blood ...
Kun Li +13 more
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Arthritis Research & Therapy, 2019 Background Spondyloarthritis (SpA) is a chronic inflammatory disease affecting primarily axial and peripheral joints and sometimes also extra-articular organs, such as the gut.
Kétia Ermoza +7 more
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The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis
JCI InsightType 1 diabetes (T1D) is precipitated by the autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans. Chemokines have been identified as major conductors of islet infiltration by autoaggressive leukocytes, including
Camilla Tondello +13 more
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Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression [PDF]
eLifeAtherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions.
Tianhan Li +16 more
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Frontiers in Immunology, 2023 A single population of interferon-regulatory factor 8 (Irf8)-dependent conventional dendritic cell (cDC type1) is considered to be responsible for both immunogenic and tolerogenic responses depending on the surrounding cytokine milieu. Here, we challenge
Adan Chari Jirmo +19 more
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Molecular Genetics & Genomic Medicine, 2021 Background Clear cell renal cell carcinoma (ccRCC) is an aggressive subtype of renal cell carcinoma. X‐C motif chemokine receptor 1 (XCR1) exerts important roles in tumor progression; however, its role in ccRCC is unclear.
Xian Chang +6 more
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Novel approaches to increase resistance to acute respiratory infections
RUDN Journal of Medicine, 2021 Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize
Svetlana V. Guryanova +5 more
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