HeliyonObjectives: The lymphotactin receptor X–C motif chemokine receptor 1 (XCR1) is an essential member of the chemokine receptor family and is related to tumor development and progression.
Wei Wu +8 more
exaly +5 more sources
Structure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1+ Dendritic Cells [PDF]
Frontiers in Immunology, 2018 XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on cross-presenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of peptides or proteins into these DC.
Sebastian Voigt, Christian Freund
exaly +7 more sources
Molecular basis for chemokine recognition and activation of XCR1 [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaThe X-C motif chemokine receptor XCR1, which selectively binds to the chemokine XCL1, is highly expressed in conventional dendritic cells subtype 1 (cDC1s) and crucial for their activation. Modulating XCR1 signaling in cDC1s could offer novel opportunities in cancer immunotherapy and vaccine development by enhancing the antigen ...
Xuan Zhang +2 more
exaly +4 more sources
Ontogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα [PDF]
Frontiers in Immunology, 2014 In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function.
Martina eBecker +10 more
doaj +5 more sources
The role of the chemokine receptor XCR1 in breast cancer cells
Breast Cancer: Targets and Therapy, 2017 Xiao Li Yang,1,* Li Guo Qi,2,* Feng Juan Lin,1 Zhou Luo Ou1 1Department of Oncology, Breast Cancer Institute, Fudan University, Shanghai Cancer Center, Shanghai, 2Department of Neurosurgery, Taian City Central Hospital, Taian, Shangdong, People’s ...
Yang XL, Qi LG, Lin FJ, Ou ZL
doaj +6 more sources
The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin [PDF]
Scientific Reports, 2017 XCR1 is selectively expressed on a conventional dendritic cell subset, the cDC1 subset, through phylogenetically distant species. The outcome of antigen-targeting to XCR1 may therefore be similar across species, permitting the translation of results from
Charlotte Deloizy +18 more
doaj +8 more sources
PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis [PDF]
Nature Communications, 2021 Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell ...
Thais G. Moreira +18 more
doaj +3 more sources
Intratumoral sustained release of resiquimod with ablative fractional laser induces efficacy in a cutaneous squamous cell carcinoma mouse model [PDF]
Frontiers in ImmunologyIntroductionThe Toll-like receptor (TLR) 7/8 agonist resiquimod has shown promise for precancerous lesions of cutaneous squamous cell carcinoma (cSCC) but remains unexplored as a treatment for cSCC.
Martin Wiinberg +6 more
doaj +2 more sources
Cell Reports, 2019 Summary: Type I interferons (IFNs) play important roles in antitumor immunity. We generated IFN-α-producing cells by genetically engineered induced pluripotent stem cell (iPSC)-derived proliferating myeloid cells (iPSC-pMCs).
Nobuhiro Tsuchiya +2 more
exaly +3 more sources
RUNX2 Phase Separation Mediates Long‐Range Regulation Between Osteoporosis‐Susceptibility Variant and XCR1 to Promote Osteoblast Differentiation [PDF]
Advanced ScienceGWASs have identified many loci associated with osteoporosis, but the underlying genetic regulatory mechanisms and the potential drug target need to be explored.
Yan Zhang +17 more
doaj +2 more sources