Results 11 to 20 of about 5,269 (176)
Structure-Function Relationship of XCL1 Used for in Vivo Targeting of Antigen Into XCR1+ Dendritic Cells [PDF]
Frontiers in Immunology, 2018 XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on cross-presenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of peptides or proteins into these DC.
Christian Freund +2 more
exaly +9 more sources
The role of the chemokine receptor XCR1 in breast cancer cells
Breast Cancer: Targets and Therapy, 2017 Xiao Li Yang,1,* Li Guo Qi,2,* Feng Juan Lin,1 Zhou Luo Ou1 1Department of Oncology, Breast Cancer Institute, Fudan University, Shanghai Cancer Center, Shanghai, 2Department of Neurosurgery, Taian City Central Hospital, Taian, Shangdong, People’s ...
Yang XL, Qi LG, Lin FJ, Ou ZL
doaj +7 more sources
The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin [PDF]
Scientific Reports, 2017 XCR1 is selectively expressed on a conventional dendritic cell subset, the cDC1 subset, through phylogenetically distant species. The outcome of antigen-targeting to XCR1 may therefore be similar across species, permitting the translation of results from
Charlotte Deloizy +18 more
doaj +10 more sources
The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis
JCI InsightType 1 diabetes (T1D) is precipitated by the autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans. Chemokines have been identified as major conductors of islet infiltration by autoaggressive leukocytes, including
Camilla Tondello +13 more
doaj +4 more sources
HeliyonObjectives: The lymphotactin receptor X–C motif chemokine receptor 1 (XCR1) is an essential member of the chemokine receptor family and is related to tumor development and progression.
Danjun Song, Jiaping Zheng
exaly +5 more sources
Fishes, 2022 Interaction between the chemokine receptor XCR1 and its ligand is closely related to the immune function in animals; however, there are only a few reports on role of XCR1 in the immune system of fish. We aimed to analyze the expression of XCR1 in various
Hailuo Yu +4 more
doaj +2 more sources
The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine. [PDF]
PLoS ONE, 2017 The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and XCL1 and their distribution among peripheral blood ...
Kun Li +13 more
doaj +2 more sources
Spatially restricted translation of the xCR1 mRNA in Xenopus embryos [PDF]
Molecular and Cellular Biology, 2009 The xCR1 protein is a maternal determinant and cofactor for nodal signaling in vertebrate embryos. The xCR1 protein accumulates specifically in the animal cells of Xenopus embryos, but maternal xCR1 mRNA is distributed equally throughout all embryonic ...
Dorey, Karel; id_orcid +5 more
core +4 more sources
Basal Internalization and Subcellular Localization of XCR1 [PDF]
Chemokines orchestrate immune cell trafficking through receptor-mediated signaling and are implicated in inflammatory, autoimmune, and neuropathic disorders.
Li, Qiao +3 more
core +2 more sources
The Journal of Immunology, 2021 West Nile Virus (WNV) is a leading cause of mosquito-borne neuroinvasive disease in the US. Following infection, WNV can cause neuronal injury and disease.
Cortes, Alejandro, Alvarado, Marina
core +2 more sources