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Frontiers in Immunology, 2022 Recent studies have indicated the involvement of chemokine-C-motif ligand 1 (XCL1) in nociceptive transmission; however, the participation of its two receptors, canonical chemokine-C-motif receptor 1 (XCR1) and integrin alpha-9 (ITGA9), recently ...
Agata Ciechanowska +2 more
exaly +3 more sources
A ubiquitinated E2-based mRNA vaccine confers complete protection against lethal challenge with classical swine fever virus [PDF]
Journal of VirologyClassical swine fever (CSF), caused by classical swine fever virus (CSFV), continues to threaten the global swine industry. Current E2-based subunit vaccines are limited by their slow adaptation to emerging viral strains and insufficient cell-mediated ...
Huanjie Zhai +11 more
doaj +2 more sources
Frontiers in Immunology, 2018 XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on cross-presenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of peptides or proteins into these DC.
Christian Freund +2 more
exaly +3 more sources
Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Chemokines orchestrate immune cell trafficking through receptor‐mediated signalling and are implicated in inflammatory, autoimmune and neuropathic disorders. The XCL1–XCR1 axis is of particular interest because XCR1 is selectively expressed on mature conventional type 1 dendritic cells (cDC1s), where it supports communication with activated ...
Li Q +3 more
europepmc +2 more sources
Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age [PDF]
Advanced ScienceTrophoblast–immune cell communication is crucial during pregnancy, with impairments linked to adverse outcomes. The accumulation of decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) in the third trimester is vital for fetal ...
Meiqi Chen +12 more
doaj +2 more sources
Single-cell analysis reveals XCL1+ CD8+ T cells as a therapeutic target in hepatocellular carcinoma [PDF]
Molecular & Cellular OncologyXCL1 (lymphotactin), a C-chemokine primarily produced by activated CD8+ T cells, remains poorly characterized in the context of immunotherapy. Here, we conducted comprehensive analyses based on multiple scRNA-seq datasets to identify the presence of XCL1+
Guowei Li +6 more
doaj +2 more sources
Multi-armored mesenchymal stem cells potentiate antitumor immunity to combat ovarian cancer [PDF]
Stem Cell Research & TherapyBackground Ovarian cancer (OC) remains one of the most lethal gynecologic malignancies often resistant to immune checkpoint blockade (ICB) due to poor infiltration of cytotoxic CD8⁺ T cells and type 1 conventional dendritic cells (cDC1s) into the tumor ...
Minghui Cao +10 more
doaj +2 more sources
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression [PDF]
eLifeAtherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions.
Tianhan Li +16 more
doaj +2 more sources
Frontiers in Immunology, 2018 The chemokine receptor XCR1 is known to be selectively expressed by cross-presenting dendritic cells (DCs), while its ligand XCL1/lymphotactin is mainly produced by activated CD8+ T cells and natural killer cells.
Naoki Oiso +2 more
exaly +3 more sources
Endocytosis Deficient Murine Xcl1-Fusion Vaccine Enhances Protective Antibody Responses in Mice
Frontiers in Immunology, 2019 Targeting antigen to surface receptors on dendritic cells (DCs) can improve antibody response against subunit vaccines. We have previously observed that human XCL1-fusion vaccines target murine Xcr1+ DCs without actively inducing endocytosis of the ...
Bjarne Bogen +2 more
exaly +3 more sources