Frontiers in Immunology, 2022 Recent studies have indicated the involvement of chemokine-C-motif ligand 1 (XCL1) in nociceptive transmission; however, the participation of its two receptors, canonical chemokine-C-motif receptor 1 (XCR1) and integrin alpha-9 (ITGA9), recently ...
Agata Ciechanowska +2 more
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Single-cell analysis reveals XCL1+ CD8+ T cells as a therapeutic target in hepatocellular carcinoma [PDF]
Molecular & Cellular OncologyXCL1 (lymphotactin), a C-chemokine primarily produced by activated CD8+ T cells, remains poorly characterized in the context of immunotherapy. Here, we conducted comprehensive analyses based on multiple scRNA-seq datasets to identify the presence of XCL1+
Guowei Li +6 more
doaj +2 more sources
Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age [PDF]
Advanced ScienceTrophoblast–immune cell communication is crucial during pregnancy, with impairments linked to adverse outcomes. The accumulation of decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) in the third trimester is vital for fetal ...
Meiqi Chen +12 more
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Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression [PDF]
eLifeAtherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions.
Tianhan Li +16 more
doaj +2 more sources
Frontiers in Immunology, 2018 XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on cross-presenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of peptides or proteins into these DC.
Sebastian Voigt, Christian Freund
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Extracellular vesicles derived from mature dendritic cells loaded with cDC1-specific chemokine XCL1 combined with chemotherapy-induced ICD for the treatment of castration-resistant prostate cancer [PDF]
Cancer Immunology, ImmunotherapyBackground Dendritic cells (DCs) derived extracellular vesicles represent a promising vehicle for the activation of adaptive immunity, demonstrating significant potential in the development of cancer nanovaccines.
Zhongqiang Fan +6 more
doaj +2 more sources
Frontiers in Immunology, 2018 The chemokine receptor XCR1 is known to be selectively expressed by cross-presenting dendritic cells (DCs), while its ligand XCL1/lymphotactin is mainly produced by activated CD8+ T cells and natural killer cells.
Kazuhiko Matsuo +2 more
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Endocytosis Deficient Murine Xcl1-Fusion Vaccine Enhances Protective Antibody Responses in Mice
Frontiers in Immunology, 2019 Targeting antigen to surface receptors on dendritic cells (DCs) can improve antibody response against subunit vaccines. We have previously observed that human XCL1-fusion vaccines target murine Xcr1+ DCs without actively inducing endocytosis of the ...
Arnar Gudjonsson +2 more
exaly +3 more sources
Identification of the key genes in children with sepsis by WGCNA in multiple GEO datasets [PDF]
Frontiers in PediatricsPediatric sepsis is a serious condition causing organ failure owing to immune dysregulation, linked to high morbidity and mortality, highlighting the need for quick detection and treatment.
Yue-chuan Shen +4 more
doaj +2 more sources
In Situ Engineering of Tumor Cells as Self‐Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy [PDF]
Advanced ScienceConventional type 1 dendritic cells (cDC1s) play a crucial role in initiating and regulating antitumor immunity. However, the insufficient infiltration and dysfunctional state of these cells within the tumor microenvironment hinder antitumor immune ...
Shuiling Jin +16 more
doaj +2 more sources