Results 11 to 20 of about 4,115 (147)

The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis [PDF]

JCI Insight
Type 1 diabetes (T1D) is precipitated by the autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans. Chemokines have been identified as major conductors of islet infiltration by autoaggressive leukocytes, including
Camilla Tondello, Christine Bender, Gregory J. Golden, Deborah Puppe, Elisa Blickberndt, Monika Bayer, Giulia K. Buchmann, Josef Pfeilschifter, Malte Bachmann, Edith Hintermann, Ralf P. Brandes, Michael R. Betts, Richard A. Kroczek, Urs Christen   +13 more
doaj   +4 more sources

The multifaceted role of XCL1 in health and disease [PDF]

Protein Science
AbstractThe chemokine XC motif chemokine ligand 1 (XCL1) is an unusually specialized member of a conserved family of around 50 small, secreted proteins that are best known for their ability to stimulate the directional migration of cells. All chemokines adopt a very similar folded structure that binds a specific G protein‐coupled receptor (GPCR), and ...
Brian Volkman, Tara L Walker
exaly   +6 more sources

Metamorphic Protein Folding Encodes Multiple Anti-Candida Mechanisms in XCL1 [PDF]

Pathogens, 2021
Candida species cause serious infections requiring prolonged and sometimes toxic therapy. Antimicrobial proteins, such as chemokines, hold great interest as potential additions to the small number of available antifungal drugs.
Acacia F. Dishman, Jie He, Brian F. Volkman, Anna R. Huppler   +3 more
doaj   +3 more sources

Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles [PDF]

Frontiers in Immunology, 2020
Periprosthetic osteolysis induced by orthopedic implant-wear particles continues to be the leading cause of arthroplasty failure in majority of patients.
Yuan Tian, Mohamad Alaa Terkawi, Mohamad Alaa Terkawi, Tomohiro Onodera, Tomohiro Onodera, Hend Alhasan, Gen Matsumae, Daisuke Takahashi, Masanari Hamasaki, Taku Ebata, Mahmoud Khamis Aly, Hiroaki Kida, Tomohiro Shimizu, Keita Uetsuki, Ken Kadoya, Norimasa Iwasaki, Norimasa Iwasaki   +16 more
doaj   +4 more sources

Immunogenicity of the Xcl1-SARS-CoV-2 Spike Fusion DNA Vaccine for COVID-19

Vaccines, 2022
SARS-CoV-2 spike (S) variants that may evade antibody-mediated immunity are emerging. Evidence shows that vaccines with a stronger immune response are still effective against mutant strains. Here, we report a targeted type 1 conventional dendritic (cDC1)
Hailong Qi, Zhongjie Sun, Yanling Yao, Ligong Chen, Xuncheng Su   +4 more
doaj   +3 more sources

The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1. [PDF]

PLoS Pathogens, 2013
CD8+ T cells play a key role in the in vivo control of HIV-1 replication via their cytolytic activity as well as their ability to secrete non-lytic soluble suppressive factors.
Christina Guzzo, Jamie Fox, Yin Lin, Huiyi Miao, Raffaello Cimbro, Brian F Volkman, Anthony S Fauci, Paolo Lusso   +7 more
doaj   +4 more sources

Multi-layered functional genomics prioritizes candidate effectors and regulatory mechanisms of ankylosing spondylitis [PDF]

Frontiers in Immunology
BackgroundAnkylosing spondylitis (AS) is a chronic inflammatory arthropathy with heritability estimated at approximately 90%, yet the effector genes and regulatory mechanisms beyond the well-established HLA-B*27 association remain incompletely defined ...
Fanyu Meng, Fanyu Meng, Ling Chen, Meng Li, Qingqing Zhang, Peiying Wang, Ruifeng Lin, Jiani Liu, Zhao Yuan, Kexin Chen, Zhaoxia Li, Yetong Xie, Abuduwahapu Aierken, Abuduwahapu Aierken, Furkat Yalkun, Furkat Yalkun, Chulan Li, Yuan Ma, Yuan Ma, Jianhui Chen, Ziwen Xu, Fei Zhong, Fei Zhong, Fei Zhong   +23 more
doaj   +2 more sources

Extracellular vesicles derived from mature dendritic cells loaded with cDC1-specific chemokine XCL1 combined with chemotherapy-induced ICD for the treatment of castration-resistant prostate cancer [PDF]

Cancer Immunology, Immunotherapy
Background Dendritic cells (DCs) derived extracellular vesicles represent a promising vehicle for the activation of adaptive immunity, demonstrating significant potential in the development of cancer nanovaccines.
Zhongqiang Fan, Zhao Wang, Hui Zhang, Hao Zhang, Rui Zhao, Shimiao Zhu, Xiaoqiang Liu   +6 more
doaj   +2 more sources

Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants [PDF]

Vaccines
Background: Human papillomavirus (HPV) is a prevalent infection affecting both men and women, leading to various cytological lesions. Therapeutic vaccines mount a HPV-specific CD8+ cytotoxic T lymphocyte response, thus clearing HPV-infected cells ...
Zhongjie Sun, Zhongyan Wu, Xuncheng Su
doaj   +2 more sources

Identification of the key genes in children with sepsis by WGCNA in multiple GEO datasets [PDF]

Frontiers in Pediatrics
Pediatric sepsis is a serious condition causing organ failure owing to immune dysregulation, linked to high morbidity and mortality, highlighting the need for quick detection and treatment.
Yue-chuan Shen, Yue-chuan Shen, Dao-jun Yu, Ze Yu, Xue Zhao   +4 more
doaj   +2 more sources