Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control [PDF]
Frontiers in Immunology, 2019 Cross-presenting Xcr1+CD8α DCs are attractive APCs to target for therapeutic cancer vaccines, as they are able to take up and process antigen from dying tumor cells for their MHCI-restricted presentation to CD8 T cells.
Melody Swartz +2 more
exaly +9 more sources
The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis [PDF]
JCI InsightType 1 diabetes (T1D) is precipitated by the autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans. Chemokines have been identified as major conductors of islet infiltration by autoaggressive leukocytes, including
Camilla Tondello +13 more
doaj +5 more sources
Metamorphic Protein Folding Encodes Multiple Anti-Candida Mechanisms in XCL1 [PDF]
Pathogens, 2021 Candida species cause serious infections requiring prolonged and sometimes toxic therapy. Antimicrobial proteins, such as chemokines, hold great interest as potential additions to the small number of available antifungal drugs.
Acacia F. Dishman +3 more
doaj +4 more sources
Immunogenicity of the Xcl1-SARS-CoV-2 Spike Fusion DNA Vaccine for COVID-19
Vaccines, 2022 SARS-CoV-2 spike (S) variants that may evade antibody-mediated immunity are emerging. Evidence shows that vaccines with a stronger immune response are still effective against mutant strains. Here, we report a targeted type 1 conventional dendritic (cDC1)
Hailong Qi +4 more
doaj +4 more sources
Endocytosis Deficient Murine Xcl1-Fusion Vaccine Enhances Protective Antibody Responses in Mice [PDF]
Frontiers in Immunology, 2019 Targeting antigen to surface receptors on dendritic cells (DCs) can improve antibody response against subunit vaccines. We have previously observed that human XCL1-fusion vaccines target murine Xcr1+ DCs without actively inducing endocytosis of the ...
Arnar Gudjonsson +5 more
doaj +7 more sources
The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1. [PDF]
PLoS Pathogens, 2013 CD8+ T cells play a key role in the in vivo control of HIV-1 replication via their cytolytic activity as well as their ability to secrete non-lytic soluble suppressive factors.
Christina Guzzo +7 more
doaj +5 more sources
Resurrected Ancestors Reveal Origins of Metamorphism in XCL1 [PDF]
Trends in Biochemical Sciences, 2021 In a recent study, Dishman et al. resurrected ancestors of the metamorphic chemokine, XCL1, inferred through phylogenetics, and found that metamorphism arose in the XCL1 lineage ~150 million years ago.
Wang, Lee-Ping +2 more
core +6 more sources
Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants [PDF]
VaccinesBackground: Human papillomavirus (HPV) is a prevalent infection affecting both men and women, leading to various cytological lesions. Therapeutic vaccines mount a HPV-specific CD8+ cytotoxic T lymphocyte response, thus clearing HPV-infected cells ...
Zhongjie Sun, Zhongyan Wu, Xuncheng Su
doaj +3 more sources
The Role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation by Murine and Human Dendritic Cells [PDF]
Frontiers in Immunology, 2012 Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of DC known to be involved in antigen cross-presentation.
Richard A Kroczek, Volker Henn
exaly +6 more sources
Examination of glycosaminoglycan binding sites on the XCL1 dimer [PDF]
Biochemistry, 2016 Known for its distinct metamorphic behavior, XCL1 interconverts between a canonical chemokine folded monomer (XCL1mon) that interacts with the receptor, XCR1, and a unique dimer (XCL1dim) that interacts with glycosaminoglycans and inhibits HIV-1 activity.
Peterson, Francis C +15 more
core +7 more sources