The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis [PDF]
JCI InsightType 1 diabetes (T1D) is precipitated by the autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans. Chemokines have been identified as major conductors of islet infiltration by autoaggressive leukocytes, including
Camilla Tondello +13 more
doaj +5 more sources
Immunogenicity of the Xcl1-SARS-CoV-2 Spike Fusion DNA Vaccine for COVID-19
Vaccines, 2022 SARS-CoV-2 spike (S) variants that may evade antibody-mediated immunity are emerging. Evidence shows that vaccines with a stronger immune response are still effective against mutant strains. Here, we report a targeted type 1 conventional dendritic (cDC1)
Hailong Qi +4 more
doaj +4 more sources
Metamorphic Protein Folding Encodes Multiple Anti-Candida Mechanisms in XCL1 [PDF]
Pathogens, 2021 Candida species cause serious infections requiring prolonged and sometimes toxic therapy. Antimicrobial proteins, such as chemokines, hold great interest as potential additions to the small number of available antifungal drugs.
Acacia F. Dishman +3 more
doaj +4 more sources
Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles [PDF]
Frontiers in Immunology, 2020 Periprosthetic osteolysis induced by orthopedic implant-wear particles continues to be the leading cause of arthroplasty failure in majority of patients.
Yuan Tian +16 more
doaj +5 more sources
The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1. [PDF]
PLoS Pathogens, 2013 CD8+ T cells play a key role in the in vivo control of HIV-1 replication via their cytolytic activity as well as their ability to secrete non-lytic soluble suppressive factors.
Christina Guzzo +7 more
doaj +5 more sources
Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control [PDF]
Frontiers in Immunology, 2019 Cross-presenting Xcr1+CD8α DCs are attractive APCs to target for therapeutic cancer vaccines, as they are able to take up and process antigen from dying tumor cells for their MHCI-restricted presentation to CD8 T cells.
Natalia K. Botelho +6 more
doaj +8 more sources
Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants [PDF]
VaccinesBackground: Human papillomavirus (HPV) is a prevalent infection affecting both men and women, leading to various cytological lesions. Therapeutic vaccines mount a HPV-specific CD8+ cytotoxic T lymphocyte response, thus clearing HPV-infected cells ...
Zhongjie Sun, Zhongyan Wu, Xuncheng Su
doaj +3 more sources
Expression von Lymphotaktin (XCL1) bei der Wegener'schen Granulomatose [PDF]
, 2022 OBJECTIVE: In Wegener's granulomatosis (WG), vasculitic lesions are characterized by prominent infiltration of polymorphonuclear neutrophils (PMN) and T cells, but underlying pathogenic mechanisms remain to be defined. We analyzed the expression and functional role of the C-class chemokine lymphotactin, XCL1, in WG.METHODS: Sera and peripheral blood ...
Brandt, Philip +5 more
openaire +3 more sources
Struktur-Funktionsanalyse des Chemokins XCL1
, 2021 Einleitung Chemokine vermitteln die Interaktion von Immunzellen. Das Chemokin XCL1 wird von aktivierten CD8+ T-Zellen und NK-Zellen sezerniert und besitzt die für Chemokine typische Tertiärstruktur, bestehend aus einem N-Terminus, einem antiparallelen β-Faltblatt, einer α Helix und einem freien C-Terminus von etwa 20 Aminosäuren.
Kroczek, Arthur Leonard
openaire +2 more sources
The Multifaceted Role of XCL1 in Health and Disease [PDF]
Protein ScienceAbstractThe chemokine XC motif chemokine ligand 1 (XCL1) is an unusually specialized member of a conserved family of around 50 small, secreted proteins that are best known for their ability to stimulate the directional migration of cells. All chemokines adopt a very similar folded structure that binds a specific G protein‐coupled receptor (GPCR), and ...
Brian F Volkman +2 more
exaly +6 more sources