Results 11 to 20 of about 6,545 (188)

The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis [PDF]

JCI Insight
Type 1 diabetes (T1D) is precipitated by the autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans. Chemokines have been identified as major conductors of islet infiltration by autoaggressive leukocytes, including
Camilla Tondello, Christine Bender, Gregory J. Golden, Deborah Puppe, Elisa Blickberndt, Monika Bayer, Giulia K. Buchmann, Josef Pfeilschifter, Malte Bachmann, Edith Hintermann, Ralf P. Brandes, Michael R. Betts, Richard A. Kroczek, Urs Christen   +13 more
doaj   +4 more sources

The multifaceted role of XCL1 in health and disease [PDF]

Protein Science
AbstractThe chemokine XC motif chemokine ligand 1 (XCL1) is an unusually specialized member of a conserved family of around 50 small, secreted proteins that are best known for their ability to stimulate the directional migration of cells. All chemokines adopt a very similar folded structure that binds a specific G protein‐coupled receptor (GPCR), and ...
Acacia F Dishman, Brian F Volkman, Tara L Walker   +2 more
exaly   +5 more sources

Metamorphic Protein Folding Encodes Multiple Anti-Candida Mechanisms in XCL1 [PDF]

Pathogens, 2021
Candida species cause serious infections requiring prolonged and sometimes toxic therapy. Antimicrobial proteins, such as chemokines, hold great interest as potential additions to the small number of available antifungal drugs.
Acacia F. Dishman, Jie He, Brian F. Volkman, Anna R. Huppler   +3 more
doaj   +3 more sources

Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles [PDF]

Frontiers in Immunology, 2020
Periprosthetic osteolysis induced by orthopedic implant-wear particles continues to be the leading cause of arthroplasty failure in majority of patients.
Yuan Tian, Mohamad Alaa Terkawi, Mohamad Alaa Terkawi, Tomohiro Onodera, Tomohiro Onodera, Hend Alhasan, Gen Matsumae, Daisuke Takahashi, Masanari Hamasaki, Taku Ebata, Mahmoud Khamis Aly, Hiroaki Kida, Tomohiro Shimizu, Keita Uetsuki, Ken Kadoya, Norimasa Iwasaki, Norimasa Iwasaki   +16 more
doaj   +4 more sources

Immunogenicity of the Xcl1-SARS-CoV-2 Spike Fusion DNA Vaccine for COVID-19

Vaccines, 2022
SARS-CoV-2 spike (S) variants that may evade antibody-mediated immunity are emerging. Evidence shows that vaccines with a stronger immune response are still effective against mutant strains. Here, we report a targeted type 1 conventional dendritic (cDC1)
Hailong Qi, Zhongjie Sun, Yanling Yao, Ligong Chen, Xuncheng Su   +4 more
doaj   +3 more sources

The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1. [PDF]

PLoS Pathogens, 2013
CD8+ T cells play a key role in the in vivo control of HIV-1 replication via their cytolytic activity as well as their ability to secrete non-lytic soluble suppressive factors.
Christina Guzzo, Jamie Fox, Yin Lin, Huiyi Miao, Raffaello Cimbro, Brian F Volkman, Anthony S Fauci, Paolo Lusso   +7 more
doaj   +4 more sources

Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants [PDF]

Vaccines
Background: Human papillomavirus (HPV) is a prevalent infection affecting both men and women, leading to various cytological lesions. Therapeutic vaccines mount a HPV-specific CD8+ cytotoxic T lymphocyte response, thus clearing HPV-infected cells ...
Zhongjie Sun, Zhongyan Wu, Xuncheng Su
doaj   +2 more sources

Macrophages in tertiary lymphoid structures promote apoptosis of ATF4-positive gastric cancer cells via IL18 [PDF]

Journal of Translational Medicine
Background Gastric cancer (GC) is a globally prevalent and highly fatal malignancy of the digestive system. Despite its transformative role in gastric cancer, immunotherapy’s efficacy is limited by the complexity and incomplete understanding of the ...
Lu Zhou, Xuelong Li, Junming Wu, Tianqing Zheng, Manru Lin, Yangjian Ou, Hong Zhou, Steven Mo, Xueqiong Han, Jinyu Xiang, Wenjing Gong   +10 more
doaj   +2 more sources

Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance [PDF]

Journal of Inflammation Research
Yiyu Hong,* Qiutong Chen,* Hua Xie, Mingliu Ma, Siting Gan, Yuqi Zhang, Zhaozhong Xu Department of Emergency, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally ...
Hong Y, Chen Q, Xie H, Ma M, Gan S, Zhang Y, Xu Z   +6 more
doaj   +2 more sources

Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control [PDF]

Frontiers in Immunology, 2019
Cross-presenting Xcr1+CD8α DCs are attractive APCs to target for therapeutic cancer vaccines, as they are able to take up and process antigen from dying tumor cells for their MHCI-restricted presentation to CD8 T cells.
Natalia K. Botelho, Benjamin O. Tschumi, Jeffrey A. Hubbell, Melody A. Swartz, Melody A. Swartz, Alena Donda, Pedro Romero   +6 more
doaj   +5 more sources