The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine. [PDF]
PLoS ONE, 2017 The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and XCL1 and their distribution among peripheral blood ...
Kun Li +13 more
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Specific binding‐induced modulation of the
Biopolymers, 2020 AbstractThe metamorphic protein XCL1 switches between two distinct native structures with different functions in the human immune system. This structural interconversion requires complete rearrangement of all hydrogen bonding networks, yet fold‐switching occurs spontaneously and reversibly in solution. One structure occupies the canonical α‐β chemokine
Acacia F. Dishman +2 more
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A Requirement for Metamorphic Interconversion in the Antimicrobial Activity of Chemokine XCL1 [PDF]
Biochemistry, 2016 Chemokines make up a superfamily of ∼50 small secreted proteins (8-12 kDa) involved in a host of physiological processes and disease states, with several previously shown to have direct antimicrobial activity comparable to that of defensins in efficacy.
Amanda M, Nevins +7 more
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A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability [PDF]
Neuroscience, 2018 Chemokines are known to have a role in the nervous system, influencing a range of processes including the development of chronic pain. To date there are very few studies describing the functions of the chemokine lymphotactin (XCL1) or its receptor (XCR1) in the nervous system.
Bird, E.V. +6 more
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Crowded environments tune the fold-switching in metamorphic proteins
Communications Chemistry, 2023 Metamorphic proteins such as circadian clock protein KaiB and human chemokine XCL1 play vital roles in regulating biological processes, including gene expression, circadian clock and innate immune responses, and perform distinct functions in living cell ...
Ning Zhang +3 more
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Dendritic cell-targeting chemokines inhibit colorectal cancer progression
Exploration of Targeted Anti-tumor Therapy, 2022 Aim: Recent progress in cancer immunotherapy has shown its promise and prompted researchers to develop novel therapeutic strategies. Dendritic cells (DCs) are professional antigen-presenting cells crucial for initiating adaptive anti-tumor immunity ...
Pengkun Yuan +4 more
doaj +1 more source
Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis [PDF]
Biotechnology Letters, 2008 Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for
Zavala Flores, Laura Mireya +9 more
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The XCL1-XCR1 axis supports intestinal tissue residency and antitumor immunity. [PDF]
J Exp MedTissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated with improved clinical outcomes. However, the cellular interactions that program TRM differentiation and function are not well understood.
Ferry A +11 more
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Depot-specific inflammation with decreased expression of ATM2 in white adipose tissues induced by high-margarine/lard intake. [PDF]
PLoS ONE, 2017 A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans
Nannan Wang +8 more
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Diluted Random Fields in Mixed Cyanide Crystals [PDF]
, 1997 A percolation argument and a dilute compressible random field Ising model are used to present a simple model for mixed cyanide crystals. The model reproduces quantitatively several features of the phase diagrams altough some crude approximations are made.
Fontaine D. +7 more
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