Specific binding‐induced modulation of the
Biopolymers, 2020 AbstractThe metamorphic protein XCL1 switches between two distinct native structures with different functions in the human immune system. This structural interconversion requires complete rearrangement of all hydrogen bonding networks, yet fold‐switching occurs spontaneously and reversibly in solution. One structure occupies the canonical α‐β chemokine
Acacia F. Dishman +2 more
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A Requirement for Metamorphic Interconversion in the Antimicrobial Activity of Chemokine XCL1 [PDF]
Biochemistry, 2016 Chemokines make up a superfamily of ∼50 small secreted proteins (8-12 kDa) involved in a host of physiological processes and disease states, with several previously shown to have direct antimicrobial activity comparable to that of defensins in efficacy.
Amanda M, Nevins +7 more
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The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine. [PDF]
PLoS ONE, 2017 The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and XCL1 and their distribution among peripheral blood ...
Kun Li +13 more
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A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability [PDF]
Neuroscience, 2018 Chemokines are known to have a role in the nervous system, influencing a range of processes including the development of chronic pain. To date there are very few studies describing the functions of the chemokine lymphotactin (XCL1) or its receptor (XCR1) in the nervous system.
Bird, E.V. +6 more
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Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis [PDF]
Biotechnology Letters, 2008 Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for
Zavala Flores, Laura Mireya +9 more
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Crowded environments tune the fold-switching in metamorphic proteins
Communications Chemistry, 2023 Metamorphic proteins such as circadian clock protein KaiB and human chemokine XCL1 play vital roles in regulating biological processes, including gene expression, circadian clock and innate immune responses, and perform distinct functions in living cell ...
Ning Zhang +3 more
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Dendritic cell-targeting chemokines inhibit colorectal cancer progression
Exploration of Targeted Anti-tumor Therapy, 2022 Aim: Recent progress in cancer immunotherapy has shown its promise and prompted researchers to develop novel therapeutic strategies. Dendritic cells (DCs) are professional antigen-presenting cells crucial for initiating adaptive anti-tumor immunity ...
Pengkun Yuan +4 more
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Aberrant Tissue Positioning of Metallophilic Macrophages in the Thymus of XCL1‐Deficient Mice [PDF]
The Anatomical Record, 2014 ABSTRACTMetallophilic macrophages hold a strategic position within the thymic tissue and play a considerable function in thymic physiology. The development and positioning of these cells within thymic tissue are regulated by complex molecular mechanisms involving different cytokine/chemokine axes.
Novica M. Milićević +6 more
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Expression von Lymphotaktin (XCL1) bei der Wegener'schen Granulomatose [PDF]
, 2022 OBJECTIVE: In Wegener's granulomatosis (WG), vasculitic lesions are characterized by prominent infiltration of polymorphonuclear neutrophils (PMN) and T cells, but underlying pathogenic mechanisms remain to be defined. We analyzed the expression and functional role of the C-class chemokine lymphotactin, XCL1, in WG.METHODS: Sera and peripheral blood ...
Brandt, Philip +5 more
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Depot-specific inflammation with decreased expression of ATM2 in white adipose tissues induced by high-margarine/lard intake. [PDF]
PLoS ONE, 2017 A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans
Nannan Wang +8 more
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