Results 31 to 40 of about 4,834 (170)

Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation [PDF]

ACS Chemical Biology, 2015
Unlike other chemokines, XCL1 undergoes a distinct metamorphic interconversion between a canonical monomeric chemokine fold and a unique β-sandwich dimer. The monomeric conformation binds and activates the receptor XCR1, whereas the dimer binds extracellular matrix glycosaminoglycans and has been associated with anti-human immunodeficiency virus (HIV ...
Jamie C, Fox, Robert C, Tyler, Christina, Guzzo, Robbyn L, Tuinstra, Francis C, Peterson, Paolo, Lusso, Brian F, Volkman   +6 more
openaire   +3 more sources

Extracellular vesicles derived from mature dendritic cells loaded with cDC1-specific chemokine XCL1 combined with chemotherapy-induced ICD for the treatment of castration-resistant prostate cancer [PDF]

Cancer Immunology, Immunotherapy
Background Dendritic cells (DCs) derived extracellular vesicles represent a promising vehicle for the activation of adaptive immunity, demonstrating significant potential in the development of cancer nanovaccines.
Zhongqiang Fan, Zhao Wang, Hui Zhang, Hao Zhang, Rui Zhao, Shimiao Zhu, Xiaoqiang Liu   +6 more
doaj   +2 more sources

In Situ Engineering of Tumor Cells as Self‐Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy [PDF]

Advanced Science
Conventional type 1 dendritic cells (cDC1s) play a crucial role in initiating and regulating antitumor immunity. However, the insufficient infiltration and dysfunctional state of these cells within the tumor microenvironment hinder antitumor immune ...
Shuiling Jin, Xiaoxi Wang, Bingyu Li, Xueqin Zhu, Zimai Liu, Jiao Lu, Yuanyuan Wei, Zixian Wu, Kai Li, Tiantian Zhang, Zonghong He, Pingping Zhu, Yuanming Qi, Benyu Liu, Hui Liu, Yongchao Wang, Zhenzhen Chen   +16 more
doaj   +2 more sources

Identification of the key genes in children with sepsis by WGCNA in multiple GEO datasets [PDF]

Frontiers in Pediatrics
Pediatric sepsis is a serious condition causing organ failure owing to immune dysregulation, linked to high morbidity and mortality, highlighting the need for quick detection and treatment.
Yue-chuan Shen, Yue-chuan Shen, Dao-jun Yu, Ze Yu, Xue Zhao   +4 more
doaj   +2 more sources

Transcutaneous immunization with a highly active form of XCL1 as a vaccine adjuvant using a hydrophilic gel patch elicits long-term CD8+ T cell responses

Journal of Pharmacological Sciences, 2020
Memory CD8+ cytotoxic T-lymphocytes (CTLs) play a key role in protective immunity against infection and cancer. However, the induction of memory CTLs with currently available vaccines remains difficult.
Momo Kamei, Kazuhiko Matsuo, Haruka Imanishi, Yuta Hara, Ying-Shu Quen, Fumio Kamiyama, Naoki Oiso, Akira Kawada, Naoki Okada, Takashi Nakayama   +9 more
doaj   +2 more sources

Macrophages in tertiary lymphoid structures promote apoptosis of ATF4-positive gastric cancer cells via IL18 [PDF]

Journal of Translational Medicine
Background Gastric cancer (GC) is a globally prevalent and highly fatal malignancy of the digestive system. Despite its transformative role in gastric cancer, immunotherapy’s efficacy is limited by the complexity and incomplete understanding of the ...
Lu Zhou, Xuelong Li, Junming Wu, Tianqing Zheng, Manru Lin, Yangjian Ou, Hong Zhou, Steven Mo, Xueqiong Han, Jinyu Xiang, Wenjing Gong   +10 more
doaj   +2 more sources

Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance [PDF]

Journal of Inflammation Research
Yiyu Hong,* Qiutong Chen,* Hua Xie, Mingliu Ma, Siting Gan, Yuqi Zhang, Zhaozhong Xu Department of Emergency, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally ...
Hong Y, Chen Q, Xie H, Ma M, Gan S, Zhang Y, Xu Z   +6 more
doaj   +2 more sources

The role of XCR1 and its ligand XCL1 in antigen cross-presentation by murine and human dendritic cells [PDF]

Frontiers in Immunology, 2012
Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of DC known to be involved in antigen cross-presentation.
Richard A. Kroczek, Volker eHenn
doaj   +4 more sources

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection

Frontiers in Immunology, 2022
Targeting antigen to conventional dendritic cells (cDCs) can improve antigen-specific immune responses and additionally be used to influence the polarization of the immune responses. However, the mechanisms by which this is achieved are less clear.
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Sonja Bobic, Sonja Bobic, Anna Lysén, Anna Lysén, Peter Csaba Huszthy, Peter Csaba Huszthy, Arnar Gudjonsson, Arnar Gudjonsson, Ranveig Braathen, Ranveig Braathen, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +16 more
doaj   +1 more source

Specific binding‐induced modulation of the XCL1 metamorphic equilibrium [PDF]

Biopolymers, 2020
AbstractThe metamorphic protein XCL1 switches between two distinct native structures with different functions in the human immune system. This structural interconversion requires complete rearrangement of all hydrogen bonding networks, yet fold‐switching occurs spontaneously and reversibly in solution. One structure occupies the canonical α‐β chemokine
Acacia F. Dishman, Francis C. Peterson, Brian F. Volkman   +2 more
openaire   +2 more sources