Results 51 to 60 of about 6,545 (188)

Tissue Determinants of Human NK Cell Development, Function, and Residence. [PDF]

, 2020
Immune responses in diverse tissue sites are critical for protective immunity and homeostasis. Here, we investigate how tissue localization regulates the development and function of human natural killer (NK) cells, innate lymphocytes important for anti ...
Arakawa-Hoyt, Janice, Carpenter, Dustin J, Dogra, Pranay, Farber, Donna L, Fong, Lawrence, Kubota, Masaru, Lanier, Lewis L, Li Poon, Maya Meimei, Li, Jacky, Ma, Wenji, Matsumoto, Rei, Rancan, Chiara, Senda, Takashi, Shen, Yufeng, Szabo, Peter A, Thapa, Puspa, Toth, Marta   +16 more
core   +2 more sources

Chemokine Expression in Peripheral Tissues from the Monosodium Lodoacetate Model of Chronic Joint Pain [PDF]

, 2013
Background Chronic pain arising from degenerative diseases of the joint such as osteoarthritis (OA) has a strong peripheral component which is likely to be mediator driven. Current treatments which reduce the production of such mediators i.e.
David LH Bennett, Hannes Kiesewetter, James R Perkins, John M Dawes, Stephen B McMahon   +4 more
core   +1 more source

A geometrical model for Mixed cyanide crystals

, 1999
A model of diluted random field sustained by quenched volume deformations is shown to reproduce puzzling physical features found in X(CN)_{x}Y_{1-x} mixed cyanide crystals. X is an alkali metal (K, Na or Rb) and Y is a spherical halogen ion (Br, Cl or I).
Aharony, Andelman, Binder, Galam, Galam, Galam, Galam, Galam, Galam, Henriques, Hessinger, Höchli, Kaufman, Knorr, Kwiecien, Loidl, Mattis, Serge Galam   +17 more
core   +1 more source

Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor [PDF]

, 2013
Viruses have long been studied not only for their pathology and associated disease but also as model systems for understanding cellular and immunological processes. Rodent herpesvirus Peru (RHVP) is a recently characterized rhadinovirus related to murine
Alcami, Alcami, Alcami, Alcami, Alcami, Alejo, Alexander, Alexander-Brett, Arnold, Bahar, Bursill, Cardin, Cyster, D. H. Fremont, D. J. Lenschow, Dabbagh, Epperson, Esko, Graham, Herr, Hileman, Houser, Hughes, Hughes, Jensen, K. Monte, Kelley, Lalani, Lalani, Lateef, Lateef, Lau, Lau, Liu, Loh, Lucas, M. Cella, Maghazachi, Martin, Miley, Moser, Murphy, O. Y. Lubman, Proudfoot, Proudfoot, Pyo, Rice, Ruiz-Arguello, Russo, Seet, Seet, Strockbine, van Berkel, van Berkel, Viejo-Borbolla, Virgin, Wang, X. Wang, Y. H. Huang   +58 more
core   +2 more sources

Bordetella spp. block eosinophil recruitment to suppress the generation of early mucosal protection

Cell Reports, 2023
Summary: Bordetella spp. are respiratory pathogens equipped with immune evasion mechanisms. We previously characterized a Bordetella bronchiseptica mutant (RB50ΔbtrS) that fails to suppress host responses, leading to rapid clearance and long-lasting ...
Nicholas J. First, Katelyn M. Parrish, Amparo Martínez-Pérez, África González-Fernández, Sushma Bharrhan, Matthew Woolard, James B. McLachlan, Rona S. Scott, Jian Wang, Monica C. Gestal   +9 more
doaj   +1 more source

GOexpress: an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data [PDF]

, 2016
Background: Identification of gene expression profiles that differentiate experimental groups is critical for discovery and analysis of key molecular pathways and also for selection of robust diagnostic or prognostic biomarkers.
Gordon, SV, Hernández, B, MacHugh, DE, Magee, DA, McGettigan, PA, Nalpas, NC, Parnell, AC, Rue-Albrecht, K   +7 more
core   +4 more sources

Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation [PDF]

ACS Chemical Biology, 2015
Unlike other chemokines, XCL1 undergoes a distinct metamorphic interconversion between a canonical monomeric chemokine fold and a unique β-sandwich dimer. The monomeric conformation binds and activates the receptor XCR1, whereas the dimer binds extracellular matrix glycosaminoglycans and has been associated with anti-human immunodeficiency virus (HIV ...
Jamie C, Fox, Robert C, Tyler, Christina, Guzzo, Robbyn L, Tuinstra, Francis C, Peterson, Paolo, Lusso, Brian F, Volkman   +6 more
openaire   +2 more sources

Transcutaneous immunization with a highly active form of XCL1 as a vaccine adjuvant using a hydrophilic gel patch elicits long-term CD8+ T cell responses

Journal of Pharmacological Sciences, 2020
Memory CD8+ cytotoxic T-lymphocytes (CTLs) play a key role in protective immunity against infection and cancer. However, the induction of memory CTLs with currently available vaccines remains difficult.
Momo Kamei, Kazuhiko Matsuo, Haruka Imanishi, Yuta Hara, Ying-Shu Quen, Fumio Kamiyama, Naoki Oiso, Akira Kawada, Naoki Okada, Takashi Nakayama   +9 more
doaj   +1 more source

On the constrained mock-Chebyshev least-squares

, 2014
The algebraic polynomial interpolation on uniformly distributed nodes is affected by the Runge phenomenon, also when the function to be interpolated is analytic.
De Marchi, Stefano, Dell'Accio, Francesco, Mazza, Mariarosa   +2 more
core   +1 more source

Comprehensive identification of onco-exaptation events in bladder cancer cell lines revealed L1PA2-SYT1 as a prognosis-relevant event

iScience, 2023
Summary: Transposable elements (TEs) can provide ectopic promoters to drive the expression of oncogenes in cancer, a mechanism known as onco-exaptation.
Ziwei Wang, Yidie Ying, Maoyu Wang, Qing Chen, Yi Wang, Xufeng Yu, Wei He, Jing Li, Shuxiong Zeng, Chuanliang Xu   +9 more
doaj   +1 more source