Results 41 to 50 of about 4,115 (147)

Expression and Function of the C-Class Chemokine Lymphotactin (XCL1) in Wegener’s Granulomatosis [PDF]

The Journal of Rheumatology, 2009
Objective.In Wegener’s granulomatosis (WG), vasculitic lesions are characterized by prominent infiltration of polymorphonuclear neutrophils (PMN) and T cells, but underlying pathogenic mechanisms remain to be defined. We analyzed the expression and functional role of the C-class chemokine lymphotactin, XCL1, in WG.Methods.Sera and peripheral blood ...
Blaschke, Sabine, Brandt, Philip, Wessels, Johannes Theodor, Mueller, Georg Anton   +3 more
openaire   +3 more sources

The XCL1-XCR1 axis supports intestinal tissue residency and antitumor immunity. [PDF]

J Exp Med
Tissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated with improved clinical outcomes. However, the cellular interactions that program TRM differentiation and function are not well understood.
Ferry A, Mempel KM, Monell A, Reina-Campos M, Scharping NE, Heeg M, Takehara KK, Schokrpur S, Kuo N, Saddawi-Konefka R, Gutkind JS, Goldrath AW.   +11 more
europepmc   +4 more sources

A novel predictive model for the recurrence of pediatric alopecia areata by bioinformatics analysis and a single-center prospective study

Frontiers in Medicine, 2023
BackgroundAlopecia areata (AA) is a disease featured by recurrent, non-scarring hair loss with a variety of clinical manifestations. The outcome of AA patients varies greatly.
Yuanquan Zheng, Yingli Nie, Jingjing Lu, Hong Yi, Guili Fu   +4 more
doaj   +1 more source

Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile

Frontiers in Immunology, 2023
Dendritic cells (DC) play a crucial role in generating and maintaining antiviral immunity. While DC are implicated in the antiviral defense by inducing T cell responses, they can also become infected by Cytomegalovirus (CMV).
Julia Cecilia Madela-Mönchinger, Silver Anthony Wolf, Emanuel Wyler, Agnieszka Bauer, Marius Mischke, Lars Möller, Vanda Juranić Lisnić, Markus Landthaler, Anna Malyshkina, Sebastian Voigt   +9 more
doaj   +1 more source

Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation [PDF]

ACS Chemical Biology, 2015
Unlike other chemokines, XCL1 undergoes a distinct metamorphic interconversion between a canonical monomeric chemokine fold and a unique β-sandwich dimer. The monomeric conformation binds and activates the receptor XCR1, whereas the dimer binds extracellular matrix glycosaminoglycans and has been associated with anti-human immunodeficiency virus (HIV ...
Jamie C, Fox, Robert C, Tyler, Christina, Guzzo, Robbyn L, Tuinstra, Francis C, Peterson, Paolo, Lusso, Brian F, Volkman   +6 more
openaire   +2 more sources

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Transcutaneous immunization with a highly active form of XCL1 as a vaccine adjuvant using a hydrophilic gel patch elicits long-term CD8+ T cell responses

Journal of Pharmacological Sciences, 2020
Memory CD8+ cytotoxic T-lymphocytes (CTLs) play a key role in protective immunity against infection and cancer. However, the induction of memory CTLs with currently available vaccines remains difficult.
Momo Kamei, Kazuhiko Matsuo, Haruka Imanishi, Yuta Hara, Ying-Shu Quen, Fumio Kamiyama, Naoki Oiso, Akira Kawada, Naoki Okada, Takashi Nakayama   +9 more
doaj   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Bordetella spp. block eosinophil recruitment to suppress the generation of early mucosal protection

Cell Reports, 2023
Summary: Bordetella spp. are respiratory pathogens equipped with immune evasion mechanisms. We previously characterized a Bordetella bronchiseptica mutant (RB50ΔbtrS) that fails to suppress host responses, leading to rapid clearance and long-lasting ...
Nicholas J. First, Katelyn M. Parrish, Amparo Martínez-Pérez, África González-Fernández, Sushma Bharrhan, Matthew Woolard, James B. McLachlan, Rona S. Scott, Jian Wang, Monica C. Gestal   +9 more
doaj   +1 more source

Machine Learning Interatomic Potentials for Energy Materials: Architectures, Training Strategies, and Applications

Advanced Energy Materials, EarlyView.
Machine learning interatomic potentials bridge quantum accuracy and computational efficiency for materials discovery. Architectures from Gaussian process regression to equivariant graph neural networks, training strategies including active learning and foundation models, and applications in solid‐state electrolytes, batteries, electrocatalysts ...
In Kee Park, Saeed Pourasad, Jinhong Mun, Arunkumar Chitteth Rajan, Tae Hyeon Park, Anand Rohit, Mohammad Zafari, Tan‐Lien Pham, Eunjae Jung, Bonseung Koo, Miran Ha, Gi Beom Sim, Hyun Gyu Park, Won Woong Choi, Kwanghyeon Jo, Soohaeng Yoo Willow, David ChangMo Yang, Chang Woo Myung, Geunsik Lee, Kwang S. Kim   +19 more
wiley   +1 more source