Results 41 to 50 of about 4,678 (171)
Dendritic cell-targeting chemokines inhibit colorectal cancer progression
Exploration of Targeted Anti-tumor Therapy, 2022 Aim: Recent progress in cancer immunotherapy has shown its promise and prompted researchers to develop novel therapeutic strategies. Dendritic cells (DCs) are professional antigen-presenting cells crucial for initiating adaptive anti-tumor immunity ...
Pengkun Yuan +4 more
doaj +1 more source
Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis [PDF]
Biotechnology Letters, 2008 Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for
Zavala Flores, Laura Mireya +9 more
openaire +2 more sources
Depot-specific inflammation with decreased expression of ATM2 in white adipose tissues induced by high-margarine/lard intake. [PDF]
PLoS ONE, 2017 A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans
Nannan Wang +8 more
doaj +1 more source
Aberrant Tissue Positioning of Metallophilic Macrophages in the Thymus of XCL1‐Deficient Mice [PDF]
The Anatomical Record, 2014 ABSTRACTMetallophilic macrophages hold a strategic position within the thymic tissue and play a considerable function in thymic physiology. The development and positioning of these cells within thymic tissue are regulated by complex molecular mechanisms involving different cytokine/chemokine axes.
Novica M. Milićević +6 more
openaire +2 more sources
Frontiers in Immunology, 2018 The chemokine receptor XCR1 is known to be selectively expressed by cross-presenting dendritic cells (DCs), while its ligand XCL1/lymphotactin is mainly produced by activated CD8+ T cells and natural killer cells.
Kazuhiko Matsuo +10 more
doaj +1 more source
Frontiers in Medicine, 2023 BackgroundAlopecia areata (AA) is a disease featured by recurrent, non-scarring hair loss with a variety of clinical manifestations. The outcome of AA patients varies greatly.
Yuanquan Zheng +4 more
doaj +1 more source
Development of adjuvants for CTL induction using high active form of lymphotactin/XCL1 [PDF]
, 2017 研究成果の概要（和文）：近年、ケモカイン受容体XCR1がCTL誘導に特化した樹状細胞に選択的に発現することが明らかとなり、XCR1のリガンドであるXCL1のCTL誘導アジュバントへの応用が期待されている。本研究では、XCL1の構造変異体 (XCL1-CC3) を作製し、XCL1-CC3が野生型XCL1-WTに比べて細胞遊走活性が向上することを明らかとした。また、in vivoにおいてXCL1-CC3は有意にCD103陽性樹状細胞を抗原投与部位に集積させ、OVA特異的CTL誘導を促進した。さらに、XCL1-
マツオ, カズヒコ, 松尾, 一彦
core +1 more source
Frontiers in Immunology, 2023 Dendritic cells (DC) play a crucial role in generating and maintaining antiviral immunity. While DC are implicated in the antiviral defense by inducing T cell responses, they can also become infected by Cytomegalovirus (CMV).
Julia Cecilia Madela-Mönchinger +9 more
doaj +1 more source
, 2013 (A) The virion capture assay was performed using immunomagnetic beads armed with 3 different XCL1 variants (WT in green bars, W55D in purple bars, and CC3 in light blue bars) as molecular baits to capture whole HIV-1 virions (strain IIIB; X4).
Christina Guzzo (305744) +7 more
core +1 more source
The XCL1-XCR1 axis supports intestinal tissue residency and antitumor immunity. [PDF]
J Exp MedTissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated with improved clinical outcomes. However, the cellular interactions that program TRM differentiation and function are not well understood.
Ferry A +11 more
europepmc +4 more sources