A Requirement for Metamorphic Interconversion in the Antimicrobial Activity of Chemokine XCL1 [PDF]
Biochemistry, 2016 Chemokines make up a superfamily of ∼50 small secreted proteins (8-12 kDa) involved in a host of physiological processes and disease states, with several previously shown to have direct antimicrobial activity comparable to that of defensins in efficacy.
Amanda M, Nevins +7 more
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Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis [PDF]
Biotechnology Letters, 2008 Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for
Zavala Flores, Laura Mireya +9 more
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Crowded environments tune the fold-switching in metamorphic proteins
Communications Chemistry, 2023 Metamorphic proteins such as circadian clock protein KaiB and human chemokine XCL1 play vital roles in regulating biological processes, including gene expression, circadian clock and innate immune responses, and perform distinct functions in living cell ...
Ning Zhang +3 more
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Dendritic cell-targeting chemokines inhibit colorectal cancer progression
Exploration of Targeted Anti-tumor Therapy, 2022 Aim: Recent progress in cancer immunotherapy has shown its promise and prompted researchers to develop novel therapeutic strategies. Dendritic cells (DCs) are professional antigen-presenting cells crucial for initiating adaptive anti-tumor immunity ...
Pengkun Yuan +4 more
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Aberrant Tissue Positioning of Metallophilic Macrophages in the Thymus of XCL1‐Deficient Mice [PDF]
The Anatomical Record, 2014 ABSTRACTMetallophilic macrophages hold a strategic position within the thymic tissue and play a considerable function in thymic physiology. The development and positioning of these cells within thymic tissue are regulated by complex molecular mechanisms involving different cytokine/chemokine axes.
Novica M. Milićević +6 more
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Depot-specific inflammation with decreased expression of ATM2 in white adipose tissues induced by high-margarine/lard intake. [PDF]
PLoS ONE, 2017 A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans
Nannan Wang +8 more
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Data for: Genetic diversity of chemokine XCL1 and its receptor XCR1 in murine rodents
, 2019 XCL1 and XCR1_Raw DNA sequence ...
Li, Y
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Development of adjuvants for CTL induction using high active form of lymphotactin/XCL1 [PDF]
, 2017 研究成果の概要（和文）：近年、ケモカイン受容体XCR1がCTL誘導に特化した樹状細胞に選択的に発現することが明らかとなり、XCR1のリガンドであるXCL1のCTL誘導アジュバントへの応用が期待されている。本研究では、XCL1の構造変異体 (XCL1-CC3) を作製し、XCL1-CC3が野生型XCL1-WTに比べて細胞遊走活性が向上することを明らかとした。また、in vivoにおいてXCL1-CC3は有意にCD103陽性樹状細胞を抗原投与部位に集積させ、OVA特異的CTL誘導を促進した。さらに、XCL1-
マツオ, カズヒコ, 松尾, 一彦
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Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]
, 2011 Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N. +35 more
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Frontiers in Medicine, 2023 BackgroundAlopecia areata (AA) is a disease featured by recurrent, non-scarring hair loss with a variety of clinical manifestations. The outcome of AA patients varies greatly.
Yuanquan Zheng +4 more
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