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Chemokines are a family of polypeptides that direct the migration of leukocytestoward a site of infection. They play a major role in autoimmune disease and chemokine receptors have recently been found to mediate HIV-1 fusion.
Richard Horuk
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ABSTRACTIn most organs, leukocyte attachment to the endothelium of blood vessels requires capture and rolling before firm adhesion is initiated by integrin activation and/or redistribution, which can be initiated by immobilized chemokines binding their cognate receptors on rolling cells.
Klaus eLey
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Antimicrobial Chemokines [PDF]
Chemokines are best known for their classic leukocyte chemotactic activity, which is critical for directing the immune response to sites of infection and injury.
Sunny C Yung, Philip M Murphy
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Chemoattractant cytokines or chemokines constitute a family of structurally related proteins found in vertebrates, bacteria or viruses. So far, 48 chemokines genes have been identified in humans, which bind to around 20 chemokine receptors.
Xavier eBLANCHET +4 more
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Chemokines and glycosaminoglycans [PDF]
Amanda E.I. Proudfoot
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Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of ...
Marta Laganà +2 more
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Microbiota, a key player in alcoholic liver disease [PDF]
Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Only 20% of heavy alcohol consumers develop alcoholic liver cirrhosis.
Anne-Marie Cassard, Dragos Ciocan
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It is now well appreciated that chemokines play a fundamental role in various aspects of CVDs (Figure). Although numerous features of chemokine biology in relation to CVD remain to be elucidated, recent studies including those published i ATVB and highlighted herein have substantially contributed to our current knowledge on chemokines.
van der Vorst, Emiel P. C. +2 more
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Specific microbiome profile in Takayasu’s arteritis and giant cell arteritis
Recent studies have provided evidence of a close link between specific microbiota and inflammatory disorders. While the vessel wall microbiota has been recently described in large vessel vasculitis (LVV) and controls, the blood microbiome in these ...
Anne Claire Desbois +4 more
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Assessment of the immunomodulatory properties of the probiotic strain Lactobacillus paracasei K5 in vitro and in vivo [PDF]
Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain that has been isolated from dairy products. Previous studies have established its probiotic potential in a series of in vitro tests, including molecular characterization, safety profiling,
Alexopoulos, Athanasios +9 more
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