Results 1 to 10 of about 291,550 (218)
Cells, 2021 Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of ...
Marta Laganà +2 more
doaj +1 more source
Microbiota, a key player in alcoholic liver disease [PDF]
Clinical and Molecular Hepatology, 2018 Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Only 20% of heavy alcohol consumers develop alcoholic liver cirrhosis.
Anne-Marie Cassard, Dragos Ciocan
doaj +1 more source
Specific microbiome profile in Takayasu’s arteritis and giant cell arteritis
Scientific Reports, 2021 Recent studies have provided evidence of a close link between specific microbiota and inflammatory disorders. While the vessel wall microbiota has been recently described in large vessel vasculitis (LVV) and controls, the blood microbiome in these ...
Anne Claire Desbois +4 more
doaj +1 more source
Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization
Cell Reports, 2016 CXCR4 plays a central role in B cell immune response, notably by promoting plasma cell (PC) migration and maintenance in the bone marrow (BM). Gain-of-function mutations in CXCR4 affecting receptor desensitization have been reported in the rare ...
Vincent Biajoux +9 more
doaj +1 more source
Frontiers in Endocrinology, 2015 Although G protein-coupled receptor (GPCR) internalization has long been considered a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the
Angélique eLEVOYE +16 more
doaj +1 more source
Transplantation of human microbiota into conventional mice durably reshapes the gut microbiota
Scientific Reports, 2018 Human microbiota-associated (HMA) mice are an important model to study the relationship between liver diseases and intestinal microbiota. We describe a new method to humanize conventional mice based on bowel cleansing with polyethylene glycol followed by
Laura Wrzosek +9 more
doaj +1 more source
Chemokine Heterocomplexes and Cancer: A Novel Chapter to Be Written in Tumor Immunity
Frontiers in Immunology, 2018 Infiltrating immune cells are a key component of the tumor microenvironment and play central roles in dictating tumor fate, either promoting anti-tumor immune responses, or sustaining tumor growth, angiogenesis and metastasis.
Gianluca D'Agostino +3 more
doaj +1 more source
Medical Sciences, 2023 Chemokines are a group of cytokines involved in the mobilization of leukocytes, which play a role in host defense and a variety of pathological conditions, including cancer.
Ari Matsumoto +4 more
doaj +1 more source
Frontiers in Immunology, 2012 Chemokines are best known for their classic leukocyte chemotactic activity, which is critical for directing the immune response to sites of infection and injury.
Sunny C Yung, Philip M Murphy
doaj +1 more source
Frontiers in Immunology, 2012 Chemoattractant cytokines or chemokines constitute a family of structurally related proteins found in vertebrates, bacteria or viruses. So far, 48 chemokines genes have been identified in humans, which bind to around 20 chemokine receptors.
Xavier eBLANCHET +4 more
doaj +1 more source