Results 1 to 10 of about 498,931 (351)

Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+/CX3CR1+ M-MDSCs into the tumor microenvironment in a redundant manner

Frontiers in Immunology, 2023
Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up ...
Gregory P. Takacs, Christian J. Kreiger, Defang Luo, Guimei Tian, Julia S. Garcia, Loic P. Deleyrolle, Duane A. Mitchell, Jeffrey K. Harrison   +7 more
doaj   +1 more source

Essential Transcription Factors and Functional Roles of Follicular Helper T Cells in Human Autoimmune Diseases [PDF]

Iranian Journal of Immunology, 2022
Follicular helper T (TFH) cells are a subset of effector CD4+ T cells that support the differentiation of antigen-specific B cells in the germinal center.
Sara Iranparast, Farhad Seif, Sanaz Tayebi, Farhad Abolnezhadian, Moosa Sharifat, Alireza Fazaeli, Neda Roshanravan, Azam Samei, Sholeh Khajoei   +8 more
doaj   +1 more source

Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7

Nature Communications, 2023
Chimeric antigen receptor (CAR)-T cell immunotherapy is a novel treatment that genetically modifies the patients’ own T cells to target and kill malignant cells. However, identification of tumour-specific antigens expressed on multiple solid cancer types,
Veronika Bandara, Jade Foeng, Batjargal Gundsambuu, Todd S. Norton, Silvana Napoli, Dylan J. McPeake, Timona S. Tyllis, Elaheh Rohani-Rad, Caitlin Abbott, Stuart J. Mills, Lih Y. Tan, Emma J. Thompson, Vasiliki M. Willet, Victoria J. Nikitaras, Jieren Zheng, Iain Comerford, Adam Johnson, Justin Coombs, Martin K. Oehler, Carmela Ricciardelli, Allison J. Cowin, Claudine S. Bonder, Michael Jensen, Timothy J. Sadlon, Shaun R. McColl, Simon C. Barry   +25 more
doaj   +1 more source

Cytokine and Chemokine mRNA Expressions after Mycobacterium tuberculosis-Specific Antigen Stimulation in Whole Blood from Hemodialysis Patients with Latent Tuberculosis Infection

Diagnostics, 2021
There have been few reports on the kinetics of hemodialyzed (HD) patients’ immune responses in latent tuberculosis infection (LTBI). Therefore, in the present study, messenger ribonucleic acid (mRNA) expression levels of nine immune markers were analyzed
Ji Young Park, Sung-Bae Park, Heechul Park, Jungho Kim, Ye Na Kim, Sunghyun Kim   +5 more
doaj   +1 more source

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

Cytokine & growth factor reviews, 2020
Highlights • COVID-19 pandemic is raging worldwide and is putting health-care systems under severe strain.• The “cytokine storm” and the subsequent ARDS result from the effects of the combination of several immune-active molecules.• The “cytokine storm ...
F. Coperchini, L. Chiovato, L. Croce, F. Magri, M. Rotondi   +4 more
semanticscholar   +1 more source

The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature

International Journal of Molecular Sciences, 2021
Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing
Jan Korbecki, K. Kojder, Patrycja Kapczuk, P. Kupnicka, B. Gawrońska-Szklarz, I. Gutowska, D. Chlubek, I. Baranowska-Bosiacka   +7 more
semanticscholar   +1 more source

Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy

Cancer Communications, 2022
Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor, nurtures a local inflammatory environment enriched with tumor cells ...
Ajaz A. Bhat, Sabah Nisar, Mayank Singh, Bazella Ashraf, Tariq Ahmad Masoodi, C. P. Prasad, Atul Sharma, Selma Maacha, Thasni Karedath, Sheema Hashem, S. Yasin, P. Bagga, Ravinder Reddy, M. Frennaux, S. Uddin, P. Dhawan, Mohammad Haris, M. Macha   +17 more
semanticscholar   +1 more source

Mouse CCL9 Chemokine Acts as Tumor Suppressor in a Murine Model of Colon Cancer

Current Issues in Molecular Biology, 2023
Colorectal cancer is the third most frequently diagnosed cancer in the world. Despite extensive studies and apparent progress in modern strategies for disease control, the treatment options are still not sufficient and effective, mostly due to frequently
Marzena Łazarczyk, Ewa Kurzejamska, Michel-Edwar Mickael, Piotr Poznański, Dominik Skiba, Mariusz Sacharczuk, Zbigniew Gaciong, Piotr Religa   +7 more
doaj   +1 more source

Role of chemokine systems in cancer and inflammatory diseases

MedComm, 2022
Chemokines are a large family of small secreted proteins that have fundamental roles in organ development, normal physiology, and immune responses upon binding to their corresponding receptors.
Hongyi Li, Min Wu, Xia Zhao
semanticscholar   +1 more source

A systematic review and meta-analysis on blood levels of cytokines/chemokines in COVID-19 cases

Gülhane Tıp Dergisi, 2022
We assessed the blood levels of the most important factors such as cytokines/chemokines in Coronavirus disease-2019 (COVID-19). PubMed/Medline and Scopus as two important databases were searched up to March 26, 2020.
Mazaher Ramezani, Houshang Nemati, Farid Najafi, Babak Sayad, Masoud Sadeghi   +4 more
doaj   +1 more source