Results 1 to 10 of about 288,488 (267)
Frontiers in Immunology, 2012 Chemoattractant cytokines or chemokines constitute a family of structurally related proteins found in vertebrates, bacteria or viruses. So far, 48 chemokines genes have been identified in humans, which bind to around 20 chemokine receptors.
Xavier eBLANCHET +4 more
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Frontiers in Immunology, 2022 Sphingolipids, ceramides and cholesterol are integral components of cellular membranes, and they also play important roles in signal transduction by regulating the dynamics of membrane receptors through their effects on membrane fluidity.
Sofía R. Gardeta +12 more
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Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
eLife, 2022 Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding of how chemokines ...
Laura Medina-Ruiz +12 more
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Frontiers in Immunology, 2022 Follicular T cells including T follicular helper (TFH) and T follicular regulatory (TFR) cells are essential in supporting and regulating the quality of antibody responses that develop in the germinal centre (GC).
Cameron R. Bastow +5 more
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Chemokines and their receptors: predictors of the therapeutic potential of mesenchymal stromal cells
Journal of Translational Medicine, 2021 Multipotent mesenchymal stromal cells (MSCs) are promising cellular therapeutics for the treatment of inflammatory and degenerative disorders due to their anti-inflammatory, immunomodulatory and regenerative potentials. MSCs can be sourced from a variety
Nerea Cuesta-Gomez +2 more
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Frontiers in Oncology, 2022 ObjectiveThe study aimed to investigate the potentiality of chemokines, including MCP-1, CCL15, CCL20, and CXCL14, as biomarkers for differential diagnosis between benign tumors and ovarian cancer (OC).MethodsA cross-sectional study was conducted in ...
Watchara Sakares +6 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2015 It is now well appreciated that chemokines play a fundamental role in various aspects of CVDs (Figure). Although numerous features of chemokine biology in relation to CVD remain to be elucidated, recent studies including those published i ATVB and highlighted herein have substantially contributed to our current knowledge on chemokines.
van der Vorst, Emiel P. C. +2 more
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Frontiers in Immunology, 2023 Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up ...
Gregory P. Takacs +7 more
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Essential Transcription Factors and Functional Roles of Follicular Helper T Cells in Human Autoimmune Diseases [PDF]
Iranian Journal of Immunology, 2022 Follicular helper T (TFH) cells are a subset of effector CD4+ T cells that support the differentiation of antigen-specific B cells in the germinal center.
Sara Iranparast +8 more
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Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7
Nature Communications, 2023 Chimeric antigen receptor (CAR)-T cell immunotherapy is a novel treatment that genetically modifies the patients’ own T cells to target and kill malignant cells. However, identification of tumour-specific antigens expressed on multiple solid cancer types,
Veronika Bandara +25 more
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