Frontiers in Immunology, 2022 BackgroundRhinovirus (RV) infections are a major cause of asthma exacerbations. Unlike other respiratory viruses, RV causes minimal cytotoxic effects on airway epithelial cells and cytokines play a critical role in its pathogenesis.
Kong Yen Liew +7 more
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Chemokine receptor-5Delta32 mutation is no risk factor for ischemic-type biliary lesion in liver transplantation [PDF]
, 2009 It has been shown that certain chemokine receptor polymorphisms may correspond to certain complications after organ transplantation. Ischemic-type biliary lesion (ITBL) encounters for major morbidity and mortality in liver transplant recipients.
Christian Moench +9 more
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Chemokine-Driven Migration of Pro-Inflammatory CD4+ T Cells in CNS Autoimmune Disease
Frontiers in Immunology, 2022 Pro-inflammatory CD4+ T helper (Th) cells drive the pathogenesis of many autoimmune conditions. Recent advances have modified views of the phenotype of pro-inflammatory Th cells in autoimmunity, extending the breadth of known Th cell subsets that operate
Aaron H. S. Heng +4 more
doaj +1 more source
CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]
, 2010 CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is
Pruenster, M +30 more
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, 2012 The recruitment of T lymphocytes during diseases such as rheumatoid arthritis is regulated by stimulation of the chemokine receptors expressed by these cells.
O'Boyle, Graeme +10 more
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Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1
, 2019 Leukocyte migration, a hallmark of the inflammatory response, is stimulated by the interactions between chemokines, which are expressed in injured or infected tissues, and chemokine receptors, which are G protein-coupled receptors (GPCRs) expressed in ...
Canals, Meritxell +3 more
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Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis [PDF]
, 2009 Introduction Chemokines and their receptors control immune cell migration during infections as well as in autoimmune responses. A 32 bp deletion in the gene of the chemokine receptor CCR5 confers protection against HIV infection, but has also been ...
Rossol, Manuela +6 more
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HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane
eLifeHIV-1 entry into susceptible cells requires the dynamic interaction of its envelope (Env) glycoprotein with the host cell receptor CD4 and a co-receptor, either CCR5 or CXCR4.
Adriana Quijada-Freire +15 more
doaj +1 more source
Chemokines and chemokine receptors in Behçet’s disease
Frontiers in Immunology, 2023 Behçet’s disease (BD), a chronic vascular inflammatory disease, is characterized by the symptoms of ocular lesions, recurrent genital and oral ulcers, skin symptoms and arthritis in addition to neurological, intestinal and vascular involvement. The pathogenesis of BD is poorly understood, and there are no effective laboratory markers for the diagnosis ...
Zhan Li +7 more
openaire +3 more sources
Monocytes/macrophages express CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation [PDF]
, 2010 Introduction: Monocytes/macrophages accumulate in the rheumatoid (RA) synovium where they play a central role in inflammation and joint destruction. Identification of molecules involved in their accumulation and differentiation is important to inform ...
Buckley, Christopher +30 more
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