Results 1 to 10 of about 5,807 (70)

Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5

Nature Communications, 2021
The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 α complex offer insight into the distinct binding modes of the ligands ...
Hui Zhang, Kun Chen, Qiuxiang Tan, Qiang Shao, Shuo Han, Chenhui Zhang, Cuiying Yi, Xiaojing Chu, Ya Zhu, Yechun Xu, Qiang Zhao, Beili Wu   +11 more
doaj   +1 more source

Prospects for targeting ACKR1 in cancer and other diseases

Frontiers in Immunology, 2023
The chemokine network is comprised of a family of signal proteins that encode messages for cells displaying chemokine G-protein coupled receptors (GPCRs).
Kyler S. Crawford, Brian F. Volkman
doaj   +1 more source

A Scintillation Proximity Assay for Real-Time Kinetic Analysis of Chemokine–Chemokine Receptor Interactions

Cells, 2022
Chemokine receptors are extensively involved in a broad range of physiological and pathological processes, making them attractive drug targets. However, despite considerable efforts, there are very few approved drugs targeting this class of seven ...
Stefanie Alexandra Eberle, Martin Gustavsson   +1 more
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Differential expression of chemokine receptors and their role in cancer imaging

Frontiers in Oncology, 2012
Chemokine/chemokine receptor interactions play diverse roles in cell migration and homeostasis. Emerging evidence suggests that cancer cells co-opt chemokine networks for survival, proliferation, immune evasion and metastasis.
Sridhar eNimmagadda
doaj   +1 more source

Development of tolerance to chemokine receptor antagonists: current paradigms and the need for further investigation

Frontiers in Immunology, 2023
Chemokine G-protein coupled receptors are validated drug targets for many diseases, including cancer, neurological, and inflammatory disorders. Despite much time and effort spent on therapeutic development, very few chemokine receptor antagonists are ...
Patrick Grudzien, Henry Neufeld, Mbasogo Ebe Eyenga, Vadim Gaponenko   +3 more
doaj   +1 more source

The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes

BMC Genomics, 2010
Background The chemokine and chemokine receptor families play critical roles in both the healthy and diseased organism mediating the migration of cells.
Ashley George, Lawrence Freya, Easton Victoria, Siddiqui Nazneen, Widdison Stephanie, Werling Dirk, Watson Michael, Coffey Tracey J   +7 more
doaj   +1 more source

CXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer

Frontiers in Molecular Biosciences, 2020
In this study, the effects of the CXC chemokine/receptor axis on lymph node and distant metastases of prostate cancer (PC) were analyzed. Further, mRNA expression data of metastatic PC were extracted from the Stand Up To Cancer–Prostate Cancer Foundation
Naoya Nagaya, Naoya Nagaya, Geun Taek Lee, Shigeo Horie, Isaac Yi Kim   +4 more
doaj   +1 more source

Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection. [PDF]

PLoS ONE, 2010
Binding of chemokines to glycosaminoglycans (GAGs) is classically described as initiating inflammatory cell migration and creating tissue chemokine gradients that direct local leukocyte chemotaxis into damaged or transplanted tissues.
Erbin Dai, Li-Ying Liu, Hao Wang, Dana McIvor, Yun Ming Sun, Colin Macaulay, Elaine King, Ganesh Munuswamy-Ramanujam, Mee Yong Bartee, Jennifer Williams, Jennifer Davids, Israel Charo, Grant McFadden, Jeffrey D Esko, Alexandra R Lucas   +14 more
doaj   +1 more source

Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy

Frontiers in Immunology, 2019
Immunotherapy is a clinically validated treatment for many cancers to boost the immune system against tumor growth and dissemination. Several strategies are used to harness immune cells: monoclonal antibodies against tumor antigens, immune checkpoint ...
Valeria Mollica Poeta, Valeria Mollica Poeta, Matteo Massara, Arianna Capucetti, Arianna Capucetti, Raffaella Bonecchi, Raffaella Bonecchi   +6 more
doaj   +1 more source

High expression of C-X-C chemokine receptor 4 and Notch1 is predictive of lymphovascular invasion and poor prognosis in lung adenocarcinoma

Tumor Biology, 2017
C-X-C chemokine receptor 4 and Notch1 have been shown to play oncogenic role individually. This study aimed to determine the combinatorial role of C-X-C chemokine receptor 4 and Notch1 in lung adenocarcinoma.
Zhuangzhuang Cong, Haiwei Wu, Zhong Guo, Tao Qin, Yang Xu, Hua Jing, Yanqing Wang, Yi Shen   +7 more
doaj   +1 more source