Results 1 to 10 of about 5,720 (219)
Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
Nature Communications, 2021 The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 Ī± complex offer insight into the distinct binding modes of the ligands ...
Hui Zhang +11 more
doaj +1 more source
Prospects for targeting ACKR1 in cancer and other diseases
Frontiers in Immunology, 2023 The chemokine network is comprised of a family of signal proteins that encode messages for cells displaying chemokine G-protein coupled receptors (GPCRs).
Kyler S. Crawford, Brian F. Volkman
doaj +1 more source
Chemokines and chemokine receptors in arthritis [PDF]
Frontiers in Bioscience, 2010 Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines.
Zoltan, Szekanecz +3 more
openaire +2 more sources
Cells, 2022 Chemokine receptors are extensively involved in a broad range of physiological and pathological processes, making them attractive drug targets. However, despite considerable efforts, there are very few approved drugs targeting this class of seven ...
Stefanie Alexandra Eberle +1 more
doaj +1 more source
Differential expression of chemokine receptors and their role in cancer imaging
Frontiers in Oncology, 2012 Chemokine/chemokine receptor interactions play diverse roles in cell migration and homeostasis. Emerging evidence suggests that cancer cells co-opt chemokine networks for survival, proliferation, immune evasion and metastasis.
Sridhar eNimmagadda
doaj +1 more source
The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes
BMC Genomics, 2010 Background The chemokine and chemokine receptor families play critical roles in both the healthy and diseased organism mediating the migration of cells.
Ashley George +7 more
doaj +1 more source
Frontiers in Immunology, 2023 Chemokine G-protein coupled receptors are validated drug targets for many diseases, including cancer, neurological, and inflammatory disorders. Despite much time and effort spent on therapeutic development, very few chemokine receptor antagonists are ...
Patrick Grudzien +3 more
doaj +1 more source
Chemokines and chemokine receptors: an overview
Frontiers in Bioscience, 2009 Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling ...
R. Bonecchi +5 more
openaire +3 more sources
Biomedical Papers, 2000 Chemokines mediate their multiple effects by binding to a variety of specific receptors, that comprise a subfamily of rhodopsin-like, 7-transmembrane domain receptors, coupled to G proteins. Some of these receptors serve as coreceptors for HIV, some of them could be expressed as markers for T lymphocyte functional differentiation.
openaire +2 more sources
Teleost Chemokines and Their Receptors [PDF]
Biology, 2015 Chemokines are a superfamily of cytokines that appeared about 650 million years ago, at the emergence of vertebrates, and are responsible for regulating cell migration under both inflammatory and physiological conditions. The first teleost chemokine gene was reported in rainbow trout in 1998. Since then, numerous chemokine genes have been identified in
Steve Bird, Carolina Tafalla
openaire +5 more sources