Results 21 to 30 of about 1,271,030 (209)

Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation [PDF]

, 2012
The recruitment of T lymphocytes during diseases such as rheumatoid arthritis is regulated by stimulation of the chemokine receptors expressed by these cells.
O'Boyle, Graeme, Palmer, Jeremy, Mavin, Emily, Kirby, John, Hine, Dominic, Barker, Catriona, Ali, Simi, Lamb, Christopher, Willet, Joseph, Fox, Christopher, Walden, Hannah   +10 more
core   +1 more source

CC chemokines and receptors in osteoarthritis: new insights and potential targets

Arthritis Research & Therapy, 2023
Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of innate and adaptive immune systems-associated inflammatory responses.
Yuchen Zhang, Di Liu, Djandan Tadum Arthur Vithran, Bosomtwe Richmond Kwabena, Wenfeng Xiao, Yusheng Li   +5 more
doaj   +1 more source

Ligand-competent fractalkine receptor is expressed on exosomes

Biochemistry and Biophysics Reports, 2021
Expression of chemokine receptor CX3CR1 is reportedly restricted to several cell types including natural killer cells, cytotoxic T cells, monocytes, and macrophages.
Eun Jeong Park, Phyoe Kyawe Myint, Michael G. Appiah, Patsorn Worawattananutai, Janjira Inprasit, Onmanee Prajuabjinda, Zay Yar Soe, Arong Gaowa, Eiji Kawamoto, Motomu Shimaoka   +9 more
doaj   +1 more source

Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis [PDF]

, 2009
Introduction Chemokines and their receptors control immune cell migration during infections as well as in autoimmune responses. A 32 bp deletion in the gene of the chemokine receptor CCR5 confers protection against HIV infection, but has also been ...
Rossol, Manuela, Keyßer, Gernot, Baerwald, Christoph, Burkhardt, Harald, Pierer, Matthias, Arnold, Sybille, Wagner, Ulf   +6 more
core   +1 more source

Mechanisms of chemokine recognition and receptor activation of chemokine receptor CCR7

Cell Reports
Summary: The chemokine receptor C-C chemokine receptor (CCR7) is essential for immune cell trafficking, cancer metastasis, and autoimmune diseases, making it a significant therapeutic target.
Yinglong Cao, Chao Zhang, Qingning Yuan, Fenghui Zhao, Qiufeng Liu, Kai Wu, Wen Hu, Jin He, Hongchun Li, H. Eric Xu, Dehua Yang, Jia Duan   +11 more
doaj   +1 more source

Multifaceted Roles of Chemokine C-X-C Motif Ligand 7 in Inflammatory Diseases and Cancer

Frontiers in Pharmacology, 2022
Over recent years, C-X-C motif ligand 7 (CXCL7) has received widespread attention as a chemokine involved in inflammatory responses. Abnormal production of the chemokine CXCL7 has been identified in different inflammatory diseases; nevertheless, the ...
Qianmiao Wu, Qianmiao Wu, Huaijun Tu, Jian Li   +3 more
doaj   +1 more source

Les chémokines et leurs récepteurs : rôle dans les infections virales et dans les pathologies cancéreuses [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2007
The chemokines and their receptors: the main functions of chemokines are cell activation and stimulation of leukocyte migration. By interacting with G protein-coupled receptors, these proteins regulate many biological processes like apoptosis ...
Catherine Burteau, Richard Kettmann, Luc Willems   +2 more
doaj  

Role of CXCR4 and SDF1 as prognostic factors for survival and the association with clinicopathology in colorectal cancer: A systematic meta-analysis

Tumor Biology, 2017
C-X-C chemokine receptor type 4 and stromal cell–derived factor-1 were proven to play important roles in several types of cancer and in many biological processes connected with tumor growth, invasion, angiogenesis, and metastasis.
Yao-ping Li, Jing Pang, Sheng Gao, Peng-yu Bai, Wen-da Wang, Pengzhou Kong, Yongping Cui   +6 more
doaj   +1 more source

Shifting CCR7 towards Its Monomeric Form Augments CCL19 Binding and Uptake

Cells, 2022
The chemokine receptor CCR7, together with its ligands, is responsible for the migration and positioning of adaptive immune cells, and hence critical for launching adaptive immune responses. CCR7 is also induced on certain cancer cells and contributes to
Oliver J. Gerken, Marc Artinger, Daniel F. Legler   +2 more
doaj   +1 more source

C–C motif chemokine ligand 2/C–C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

Neural Regeneration Research
Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.
Xiangzi Wang, Xiaofei Niu, Yingkai Wang, Yang Liu, Cheng Yang, Xuyi Chen, Zhongquan Qi   +6 more
doaj   +1 more source