Results 21 to 30 of about 241,514 (267)

Shifting CCR7 towards Its Monomeric Form Augments CCL19 Binding and Uptake

Cells, 2022
The chemokine receptor CCR7, together with its ligands, is responsible for the migration and positioning of adaptive immune cells, and hence critical for launching adaptive immune responses. CCR7 is also induced on certain cancer cells and contributes to
Oliver J. Gerken, Marc Artinger, Daniel F. Legler   +2 more
doaj   +1 more source

Role of CXCR4 and SDF1 as prognostic factors for survival and the association with clinicopathology in colorectal cancer: A systematic meta-analysis

Tumor Biology, 2017
C-X-C chemokine receptor type 4 and stromal cell–derived factor-1 were proven to play important roles in several types of cancer and in many biological processes connected with tumor growth, invasion, angiogenesis, and metastasis.
Yao-ping Li, Jing Pang, Sheng Gao, Peng-yu Bai, Wen-da Wang, Pengzhou Kong, Yongping Cui   +6 more
doaj   +1 more source

Chemokines and chemokine receptors in CNS pathology [PDF]

Journal of Neurovirology, 1999
Chemokines are small proinflammatory cytokineswhich stimulate migration of inflammatory cells invitro and in vivo. They can be divided according tostructure, function and gene localization into fourdifferent subfamilies. Chemokines have been as-cribed diverse additional functions, including reg-ulation of angiogenesis, control of cell proliferationand ...
A R, Glabinski, R M, Ransohoff
openaire   +2 more sources

Mechanisms of chemokine recognition and receptor activation of chemokine receptor CCR7

Cell Reports
Summary: The chemokine receptor C-C chemokine receptor (CCR7) is essential for immune cell trafficking, cancer metastasis, and autoimmune diseases, making it a significant therapeutic target.
Yinglong Cao, Chao Zhang, Qingning Yuan, Fenghui Zhao, Qiufeng Liu, Kai Wu, Wen Hu, Jin He, Hongchun Li, H. Eric Xu, Dehua Yang, Jia Duan   +11 more
doaj   +1 more source

Les chémokines et leurs récepteurs : rôle dans les infections virales et dans les pathologies cancéreuses [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2007
The chemokines and their receptors: the main functions of chemokines are cell activation and stimulation of leukocyte migration. By interacting with G protein-coupled receptors, these proteins regulate many biological processes like apoptosis ...
Catherine Burteau, Richard Kettmann, Luc Willems   +2 more
doaj  

Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors

eLife, 2018
Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine receptors control distinct biological processes, and the same receptor can direct different cellular responses, but the basis ...
Divyanshu Malhotra, Jimann Shin, Lilianna Solnica-Krezel, Erez Raz   +3 more
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Bidirectional Regulation of Opioid and Chemokine Function

Frontiers in Immunology, 2020
The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
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C–C motif chemokine ligand 2/C–C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

Neural Regeneration Research
Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.
Xiangzi Wang, Xiaofei Niu, Yingkai Wang, Yang Liu, Cheng Yang, Xuyi Chen, Zhongquan Qi   +6 more
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Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity.

PLoS Biology, 2020
Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets.
Tony Ngo, Bryan S Stephens, Martin Gustavsson, Lauren G Holden, Ruben Abagyan, Tracy M Handel, Irina Kufareva   +6 more
doaj   +1 more source

Helper T cells and chemokines in elderly asthma – Mechanisms of airway inflammation and remodeling: A review

Biomolecules & Biomedicine
Elderly bronchial asthma is a heterogeneous, often non-atopic disorder characterized by airway inflammation and remodeling influenced by age-related immune dysregulation. This review aims to elucidate the roles of helper T cells (Th cells) and chemokine
Youhua Wu
doaj   +1 more source