Results 31 to 40 of about 375,096 (307)

Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy

Frontiers in Immunology, 2019
Immunotherapy is a clinically validated treatment for many cancers to boost the immune system against tumor growth and dissemination. Several strategies are used to harness immune cells: monoclonal antibodies against tumor antigens, immune checkpoint ...
Valeria Mollica Poeta, Valeria Mollica Poeta, Matteo Massara, Arianna Capucetti, Arianna Capucetti, Raffaella Bonecchi, Raffaella Bonecchi   +6 more
doaj   +1 more source

High expression of C-X-C chemokine receptor 4 and Notch1 is predictive of lymphovascular invasion and poor prognosis in lung adenocarcinoma

Tumor Biology, 2017
C-X-C chemokine receptor 4 and Notch1 have been shown to play oncogenic role individually. This study aimed to determine the combinatorial role of C-X-C chemokine receptor 4 and Notch1 in lung adenocarcinoma.
Zhuangzhuang Cong, Haiwei Wu, Zhong Guo, Tao Qin, Yang Xu, Hua Jing, Yanqing Wang, Yi Shen   +7 more
doaj   +1 more source

Chemokines and chemokine receptors expression in the lesions of patients with American cutaneous leishmaniasis

Memorias do Instituto Oswaldo Cruz, 2013
American cutaneous leishmaniasis (ACL) presents distinct active clinical forms with different grades of severity, known as localised (LCL), intermediate (ICL) and diffuse (DCL) cutaneous leishmaniasis. LCL and DCL are associated with a polarised T-helper
Nilka Luisa Diaz, Olga Zerpa, Felix Jacobo Tapia   +2 more
doaj   +1 more source

Ligand-competent fractalkine receptor is expressed on exosomes

Biochemistry and Biophysics Reports, 2021
Expression of chemokine receptor CX3CR1 is reportedly restricted to several cell types including natural killer cells, cytotoxic T cells, monocytes, and macrophages.
Eun Jeong Park, Phyoe Kyawe Myint, Michael G. Appiah, Patsorn Worawattananutai, Janjira Inprasit, Onmanee Prajuabjinda, Zay Yar Soe, Arong Gaowa, Eiji Kawamoto, Motomu Shimaoka   +9 more
doaj   +1 more source

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue [PDF]

, 2014
Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets.
A Jemal, A Muller, A Pellegrino, A Zhu, A Zipin-Roitman, AF Ziober, AM Mulligan, BJ Moeller, BK Lo, C Beskow, C Grandi, CC Tong, CJ Hutchings, CL Addison, CT Allen, D Sano, E Montagna, Göran Laurell, HA Wolff, IK Kalnins, J Romanini, J Vandercappellen, J Wang, JN Sarkaria, K Annertz, K Kawada, K Kawada, KA Dinshaw, Karin Nylander, KB Pytynia, L Boldrup, L Goldberg-Bittman, L Lundqvist, Lotta Loljung, M Cojoc, M Fujita, M Liu, M Rentoft, M Rentoft, Matilda Rentoft, MF Calmon, MN Wente, N Sahu, P Silva, Philip John Coates, S Atula, S Friesland, S Matsumura, S Shintani, S Struyf, SP Schantz, SP Schantz, TC Walser, Torben Wilms, W Garavello, WA Yeudall, XL Lu, Y Matsuo   +57 more
core   +4 more sources

Viral Chemokine Receptors [PDF]

Frontiers in Immunology, 2015
When my lab sequenced the first chemokine receptors CXCR2 and CCR1 in 1991, the top BLAST hit for CCR1 was open reading frame (ORF) US28 of human cytomegalovirus (HCMV), indicating an obvious common ancestor and a possible example of gene piracy. Pox virologists had already identified virally encoded TNF and IFN-γ binding proteins, copied from the host
openaire   +3 more sources

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K., Grone H. J., Luboshits G., Nagase H., Stetler-Stevenson W. G., Stetler-Stevenson W. G., Urdiales-Viedma M., Zhang Y.   +7 more
core   +1 more source

Chemokines and chemokine receptors: an overview

Frontiers in Bioscience, 2009
Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling ...
R. Bonecchi, E.R. Galliera, E.M. Borroni, M.M. Corsi, M. Locati, A. Mantovani   +5 more
openaire   +3 more sources

Multifaceted Roles of Chemokine C-X-C Motif Ligand 7 in Inflammatory Diseases and Cancer

Frontiers in Pharmacology, 2022
Over recent years, C-X-C motif ligand 7 (CXCL7) has received widespread attention as a chemokine involved in inflammatory responses. Abnormal production of the chemokine CXCL7 has been identified in different inflammatory diseases; nevertheless, the ...
Qianmiao Wu, Qianmiao Wu, Huaijun Tu, Jian Li   +3 more
doaj   +1 more source

Influence of lipopolysaccharide on proinflammatory gene expression in human corneal, conjunctival and meibomian gland epithelial cells [PDF]

, 2018
PURPOSE: Lipopolysaccharide (LPS), a bacterial endotoxin, is known to stimulate leuokotriene B4 (LTB4) secretion by human corneal (HCECs), conjunctival (HConjECs) and meibomian gland (HMGECs) epithelial cells.
Chen, Di, Darabad, Raheleh Rahimi, Kam, Wendy R., Liu, Yang, Sahin, Afsun, Sullivan, David A.   +5 more
core   +1 more source