Results 51 to 60 of about 375,096 (307)

Mechanisms of chemokine recognition and receptor activation of chemokine receptor CCR7

Cell Reports
Summary: The chemokine receptor C-C chemokine receptor (CCR7) is essential for immune cell trafficking, cancer metastasis, and autoimmune diseases, making it a significant therapeutic target.
Yinglong Cao, Chao Zhang, Qingning Yuan, Fenghui Zhao, Qiufeng Liu, Kai Wu, Wen Hu, Jin He, Hongchun Li, H. Eric Xu, Dehua Yang, Jia Duan   +11 more
doaj   +1 more source

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands [PDF]

, 2019
Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form.
Aguilar-Pérez, Alexandra, Awad, Mohamed E., Eisa, Nada H., Elmansi, Ahmed M., Fulzele, Sadanand, Hamrick, Mark W., Herberg, Samuel, Hill, William D., Hussein, Khaled A., Isales, Carlos M., Kondrikov, Dmitry, McGee-Lawrence, Meghan E., Periyasamy-Thandavan, Sudharsan, Volkman, Brian F.   +13 more
core   +1 more source

Chemokines, Chemokine Receptors, and Allograft Rejection [PDF]

Immunity, 2001
Chemokines are pivotal mediators in allograft rejection by virtue of their activity as regulators of leukocyte movement, adhesion, and effector function. Because the regulation of effector cell infiltration is complex, it is difficult to dissect the relative role of each chemokine in the inflammatory processes leading to allograft rejection, especially
Nelson, Peter J., Krensky, Alan M.
openaire   +2 more sources

C–C motif chemokine ligand 2/C–C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

Neural Regeneration Research
Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.
Xiangzi Wang, Xiaofei Niu, Yingkai Wang, Yang Liu, Cheng Yang, Xuyi Chen, Zhongquan Qi   +6 more
doaj   +1 more source

Les chémokines et leurs récepteurs : rôle dans les infections virales et dans les pathologies cancéreuses [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2007
The chemokines and their receptors: the main functions of chemokines are cell activation and stimulation of leukocyte migration. By interacting with G protein-coupled receptors, these proteins regulate many biological processes like apoptosis ...
Catherine Burteau, Richard Kettmann, Luc Willems   +2 more
doaj  

The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]

, 2018
Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos, Amaral, Flávio Almeida, Borges, Vanessa, Castanheira, Fernanda Vargas E. Silva, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Donate, Paula Barbim, Graham, Gerard J., Kanashiro, Alexandre, Liew, Foo Y., Melo, Paulo Henrique, Pallas, Kenneth, Ramalho, Fernando Silva, Russo, Remo Castro, Sônego, Fabiane, Teixeira, Mauro Martins   +15 more
core   +1 more source

Chemokines, Chemokine Receptors and Atherosclerosis

, 2005
Publisher Summary This chapter focuses on chemokines, chemokine receptors, and atherosclerosis. Chemokines play essential roles in inflammation and disease. This family of inflammatory mediators has diverse roles in both immune and inflammatory responses, including the regulation of cellular recruitment, activation, and differentiation.
John, A, Channon, K, Greaves, D
openaire   +2 more sources

Helper T cells and chemokines in elderly asthma – Mechanisms of airway inflammation and remodeling: A review

Biomolecules & Biomedicine
Elderly bronchial asthma is a heterogeneous, often non-atopic disorder characterized by airway inflammation and remodeling influenced by age-related immune dysregulation. This review aims to elucidate the roles of helper T cells (Th cells) and chemokine
Youhua Wu
doaj   +1 more source

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity.

PLoS Biology, 2020
Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets.
Tony Ngo, Bryan S Stephens, Martin Gustavsson, Lauren G Holden, Ruben Abagyan, Tracy M Handel, Irina Kufareva   +6 more
doaj   +1 more source

RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]

, 2017
Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P., Gale, Michael, Loo, Yueh-Ming, Martinez, Jennifer, Oberst, Andrew, Oguin III, Thomas H., Olsen, Tayla M., Orozco, Susana, Snyder, Annelise G., Tait, Stephen W.G.   +9 more
core   +1 more source