Results 41 to 50 of about 5,720 (219)

Chemokines, chemokine receptors, and cancer metastasis [PDF]

Journal of Leukocyte Biology, 2006
Abstract It is clear from large clinical studies that selected chemokine receptors are often up-regulated in a large number of common human cancers, including those of the breast, lung, prostate, colon, and melanoma. Chemokine receptors and their corresponding chemokine ligands have been demonstrated to play a number of nonredundant ...
Takashi, Kakinuma, Sam T, Hwang
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

eLife, 2022
Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding of how chemokines ...
Laura Medina-Ruiz, Robin Bartolini, Gillian J Wilson, Douglas P Dyer, Francesca Vidler, Catherine E Hughes, Fabian Schuette, Samantha Love, Marieke Pingen, Alan James Hayes, Jun Fu, Adrian Francis Stewart, Gerard J Graham   +12 more
doaj   +1 more source

Chemokines, Chemokine Receptors, and Allograft Rejection [PDF]

Immunity, 2001
Chemokines are pivotal mediators in allograft rejection by virtue of their activity as regulators of leukocyte movement, adhesion, and effector function. Because the regulation of effector cell infiltration is complex, it is difficult to dissect the relative role of each chemokine in the inflammatory processes leading to allograft rejection, especially
Nelson, Peter J., Krensky, Alan M.
openaire   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

CXC chemokine receptor type 5 may induce trophoblast dysfunction and participate in the processes of unexplained missed abortion, wherein p-ERK and interleukin-6 may be involved

Heliyon
Chemokines regulate the trophoblast dysfunction involved in the occurrence and development of pathological pregnancy, including missed abortions. In particular, CXC chemokine receptor type 5 mediates cell proliferation, migration, and inflammation ...
Yanan Zhi, Pingping Zhang, Yan Luo, Yanmei Sun, Juan Li, Mingming Zhang, Yali Li   +6 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

eLife, 2018
Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink’ to facilitate evasion of host immune responses.
Timothy F Miles, Katja Spiess, Kevin M Jude, Naotaka Tsutsumi, John S Burg, Jessica R Ingram, Deepa Waghray, Gertrud M Hjorto, Olav Larsen, Hidde L Ploegh, Mette M Rosenkilde, K Christopher Garcia   +11 more
doaj   +1 more source

Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]

PLoS Computational Biology, 2018
Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer, Kristyna Pluhackova, Rainer A Böckmann   +2 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source