Results 11 to 20 of about 5,720 (219)

CXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer

Frontiers in Molecular Biosciences, 2020
In this study, the effects of the CXC chemokine/receptor axis on lymph node and distant metastases of prostate cancer (PC) were analyzed. Further, mRNA expression data of metastatic PC were extracted from the Stand Up To Cancer–Prostate Cancer Foundation
Naoya Nagaya, Naoya Nagaya, Geun Taek Lee, Shigeo Horie, Isaac Yi Kim   +4 more
doaj   +1 more source

Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection. [PDF]

PLoS ONE, 2010
Binding of chemokines to glycosaminoglycans (GAGs) is classically described as initiating inflammatory cell migration and creating tissue chemokine gradients that direct local leukocyte chemotaxis into damaged or transplanted tissues.
Erbin Dai, Li-Ying Liu, Hao Wang, Dana McIvor, Yun Ming Sun, Colin Macaulay, Elaine King, Ganesh Munuswamy-Ramanujam, Mee Yong Bartee, Jennifer Williams, Jennifer Davids, Israel Charo, Grant McFadden, Jeffrey D Esko, Alexandra R Lucas   +14 more
doaj   +1 more source

Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy

Frontiers in Immunology, 2019
Immunotherapy is a clinically validated treatment for many cancers to boost the immune system against tumor growth and dissemination. Several strategies are used to harness immune cells: monoclonal antibodies against tumor antigens, immune checkpoint ...
Valeria Mollica Poeta, Valeria Mollica Poeta, Matteo Massara, Arianna Capucetti, Arianna Capucetti, Raffaella Bonecchi, Raffaella Bonecchi   +6 more
doaj   +1 more source

Chemokines and chemokine receptors in Behçet’s disease

Frontiers in Immunology, 2023
Behçet’s disease (BD), a chronic vascular inflammatory disease, is characterized by the symptoms of ocular lesions, recurrent genital and oral ulcers, skin symptoms and arthritis in addition to neurological, intestinal and vascular involvement. The pathogenesis of BD is poorly understood, and there are no effective laboratory markers for the diagnosis ...
Zhan Li, Zhan Li, Linlin Cheng, Linlin Cheng, Haoting Zhan, Haoting Zhan, Yongzhe Li, Yongzhe Li   +7 more
openaire   +3 more sources

High expression of C-X-C chemokine receptor 4 and Notch1 is predictive of lymphovascular invasion and poor prognosis in lung adenocarcinoma

Tumor Biology, 2017
C-X-C chemokine receptor 4 and Notch1 have been shown to play oncogenic role individually. This study aimed to determine the combinatorial role of C-X-C chemokine receptor 4 and Notch1 in lung adenocarcinoma.
Zhuangzhuang Cong, Haiwei Wu, Zhong Guo, Tao Qin, Yang Xu, Hua Jing, Yanqing Wang, Yi Shen   +7 more
doaj   +1 more source

Chemokines and chemokine receptors expression in the lesions of patients with American cutaneous leishmaniasis

Memorias do Instituto Oswaldo Cruz, 2013
American cutaneous leishmaniasis (ACL) presents distinct active clinical forms with different grades of severity, known as localised (LCL), intermediate (ICL) and diffuse (DCL) cutaneous leishmaniasis. LCL and DCL are associated with a polarised T-helper
Nilka Luisa Diaz, Olga Zerpa, Felix Jacobo Tapia   +2 more
doaj   +1 more source

Ligand-competent fractalkine receptor is expressed on exosomes

Biochemistry and Biophysics Reports, 2021
Expression of chemokine receptor CX3CR1 is reportedly restricted to several cell types including natural killer cells, cytotoxic T cells, monocytes, and macrophages.
Eun Jeong Park, Phyoe Kyawe Myint, Michael G. Appiah, Patsorn Worawattananutai, Janjira Inprasit, Onmanee Prajuabjinda, Zay Yar Soe, Arong Gaowa, Eiji Kawamoto, Motomu Shimaoka   +9 more
doaj   +1 more source

Multifaceted Roles of Chemokine C-X-C Motif Ligand 7 in Inflammatory Diseases and Cancer

Frontiers in Pharmacology, 2022
Over recent years, C-X-C motif ligand 7 (CXCL7) has received widespread attention as a chemokine involved in inflammatory responses. Abnormal production of the chemokine CXCL7 has been identified in different inflammatory diseases; nevertheless, the ...
Qianmiao Wu, Qianmiao Wu, Huaijun Tu, Jian Li   +3 more
doaj   +1 more source

CC chemokines and receptors in osteoarthritis: new insights and potential targets

Arthritis Research & Therapy, 2023
Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of innate and adaptive immune systems-associated inflammatory responses.
Yuchen Zhang, Di Liu, Djandan Tadum Arthur Vithran, Bosomtwe Richmond Kwabena, Wenfeng Xiao, Yusheng Li   +5 more
doaj   +1 more source

Shifting CCR7 towards Its Monomeric Form Augments CCL19 Binding and Uptake

Cells, 2022
The chemokine receptor CCR7, together with its ligands, is responsible for the migration and positioning of adaptive immune cells, and hence critical for launching adaptive immune responses. CCR7 is also induced on certain cancer cells and contributes to
Oliver J. Gerken, Marc Artinger, Daniel F. Legler   +2 more
doaj   +1 more source