The role of the chemokine receptor CXCR4 in oral squamous cell carcinoma metastasis [PDF]
, 2010 PhDOral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. The greatest cause of mortality and surgical morbidity is due to the common spread of tumour cells from the primary lesion to the lymph nodes of the neck. This pathway is
Collier, Jonathan Marc
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Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]
, 2010 Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Sayyed, Sufyan Ali +2 more
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Chemokine receptor CCR1: A new target for progressive kidney disease [PDF]
, 2005 Infiltrating leukocytes are thought to contribute to the progression of kidney disease. Locally produced chemokines guide circulating leukocytes into the kidney, which renders therapeutic blockade of respective chemokine receptors on the leukocyte ...
Hans-Joachim Anders +3 more
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The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus [PDF]
, 1999 Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting ...
Hosie, M.J. +3 more
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ELR+ CXC chemokine signalling in cartilage homeostasis. [PDF]
, 2011 PhDThe production of ELR+ CXC chemokines is widely studied in arthritis and has been postulated to contribute to the inflammatory phenomena that eventually lead to cartilage breakdown.
Sherwood, Joanna
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Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]
, 2003 To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim +5 more
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Chemokine receptor-5Delta32 mutation is no risk factor for ischemic-type biliary lesion in liver transplantation [PDF]
, 2009 It has been shown that certain chemokine receptor polymorphisms may correspond to certain complications after organ transplantation. Ischemic-type biliary lesion (ITBL) encounters for major morbidity and mortality in liver transplant recipients.
Christian Moench +9 more
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CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]
, 2010 CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is
Pruenster, M +30 more
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Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]
, 2004 Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Anders, Hans-Joachim +3 more
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Memorias do Instituto Oswaldo Cruz, 2013 American cutaneous leishmaniasis (ACL) presents distinct active clinical forms with different grades of severity, known as localised (LCL), intermediate (ICL) and diffuse (DCL) cutaneous leishmaniasis. LCL and DCL are associated with a polarised T-helper
Nilka Luisa Diaz +2 more
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