Results 51 to 60 of about 498,931 (351)
Nature CommunicationsChemokine receptors control cell migration within the body. Here we reveal interactions between eosinophils and monocytes in the bone marrow, indirectly controlled by the atypical chemokine receptor ACKR2.
Gillian J. Wilson +11 more
doaj +1 more source
HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane
eLifeHIV-1 entry into susceptible cells requires the dynamic interaction of its envelope (Env) glycoprotein with the host cell receptor CD4 and a co-receptor, either CCR5 or CXCR4.
Adriana Quijada-Freire +15 more
doaj +1 more source
Targeting Chemokine—Glycosaminoglycan Interactions to Inhibit Inflammation
Frontiers in Immunology, 2020 Leukocyte migration into tissues depends on the activity of chemokines that form concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with their specific G protein-coupled receptors (GPCRs) on leukocytes induces ...
Helena Crijns +2 more
semanticscholar +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]
, 2004 Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Anders, Hans-Joachim +3 more
core +1 more source
eLifeCXCR4 is a ubiquitously expressed chemokine receptor that regulates leukocyte trafficking and arrest in both homeostatic and pathological states. It also participates in organogenesis, HIV-1 infection, and tumor development.
Eva M García-Cuesta +24 more
doaj +1 more source
Cells, 2021 It is important to investigate the sex-dependent roles of microglia in pain hypersensitivity as reactive microglia within the spinal dorsal horn (DH) have been reported to be pivotal in neuropathic pain induction in male rodents upon nerve injury.
Fumihiro Saika +3 more
doaj +1 more source
The role of chemokines and chemokine receptors in multiple sclerosis
International Immunopharmacology, 2020 Highlights • Summarize the study of the role of chemokines and their receptors in multiple sclerosis (MS) patients and MS animal models.• Discuss their potential significance in inflammatory injury and repair of MS.• Summarize the progress in the ...
Li-yuan Cui, Shi-Feng Chu, Nai-Hong Chen
semanticscholar +1 more source
Chemokines and Chemokine Receptors in Multiple Sclerosis [PDF]
Mediators of Inflammation, 2014 Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development of this disease.
Wenjing Cheng, Guangjie Chen
openaire +3 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source