Results 41 to 50 of about 498,931 (351)
Allergen Exposure in Murine Neonates Promoted the Development of Asthmatic Lungs
Biomedicines, 2021 We previously demonstrated that fetal allergen exposure caused T-helper 2 (Th2) cell sensitization. Although neonates are immunologically more mature than fetuses, asthmatic lungs were reportedly mitigated by neonatal allergen administration ...
Jeng-Chang Chen +3 more
doaj +1 more source
Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
Nature Communications, 2021 The chemokine receptor CCR5 plays a vital role in immune surveillance and inflammation. However, molecular details that govern its endogenous chemokine recognition and receptor activation remain elusive.
Hui Zhang +11 more
semanticscholar +1 more source
Chemokine Receptors and Phagocyte Biology in Zebrafish. [PDF]
, 2020 Phagocytes are highly motile immune cells that ingest and clear microbial invaders, harmful substances, and dying cells. Their function is critically dependent on the expression of chemokine receptors, a class of G-protein-coupled receptors (GPCRs ...
Sommer, F. +6 more
core +1 more source
Frontiers in Immunology, 2019 Activation of the innate immune system, including tissue macrophages and associated neutrophil infiltration, is an important driver of subsequent adaptive immune responses in many autoimmune diseases, including autoimmune hepatitis (AIH).
Wagdi Almishri +3 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundRhinovirus (RV) infections are a major cause of asthma exacerbations. Unlike other respiratory viruses, RV causes minimal cytotoxic effects on airway epithelial cells and cytokines play a critical role in its pathogenesis.
Kong Yen Liew +7 more
doaj +1 more source
Chemokine-Driven Migration of Pro-Inflammatory CD4+ T Cells in CNS Autoimmune Disease
Frontiers in Immunology, 2022 Pro-inflammatory CD4+ T helper (Th) cells drive the pathogenesis of many autoimmune conditions. Recent advances have modified views of the phenotype of pro-inflammatory Th cells in autoimmunity, extending the breadth of known Th cell subsets that operate
Aaron H. S. Heng +4 more
doaj +1 more source
Science, 2010 Regulating Migration The migration of cells around the body is an important factor in cancer development and the establishment of infection. Movement is induced by small proteins called chemokines, and so for a specific function, migration is controlled ...
Beili Wu +14 more
semanticscholar +1 more source
Targeting cytokine and chemokine signaling pathways for cancer therapy
Signal Transduction and Targeted TherapyCytokines are critical in regulating immune responses and cellular behavior, playing dual roles in both normal physiology and the pathology of diseases such as cancer.
Ming Yi +6 more
semanticscholar +1 more source
Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]
, 2003 To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim +5 more
core +1 more source
Soluble mediators in the function of the epidermal-immune-neuro unit in the skin
Frontiers in Immunology, 2022 Skin is the largest, environmentally exposed (barrier) organ, capable of integrating various signals into effective defensive responses. The functional significance of interactions among the epidermis and the immune and nervous systems in regulating and ...
Ewa Oleszycka +8 more
doaj +1 more source