Results 41 to 50 of about 468,477 (308)
RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]
, 2017 Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P. +9 more
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Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]
, 2006 Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer +108 more
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Chemokines: What chemokine is that? [PDF]
Current Biology, 1997 The discovery of a new and unusual member of the chemokine family illustrates the importance of chemoattractant diversity in the regulation of leukocyte movement through the body. The chemokines are now divisible into four clearly defined subgroups on the basis of structural and functional properties.
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The complex nature of CXCR4 mutations in WHIM syndrome
Frontiers in ImmunologyHeterozygous autosomal dominant mutations in the CXCR4 gene cause WHIM syndrome, a severe combined immunodeficiency disorder. The mutations primarily affect the C-terminal region of the CXCR4 chemokine receptor, specifically several potential ...
José Miguel Rodríguez-Frade +4 more
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Chemokines and chemokine receptors: an overview
Frontiers in Bioscience, 2009 Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling ...
R. Bonecchi +5 more
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Chemokines and chemokine receptors in arthritis [PDF]
Frontiers in Bioscience, 2010 Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines.
Zoltan, Szekanecz +3 more
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eLifeCXCR4 is a ubiquitously expressed chemokine receptor that regulates leukocyte trafficking and arrest in both homeostatic and pathological states. It also participates in organogenesis, HIV-1 infection, and tumor development.
Eva M García-Cuesta +24 more
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Soluble mediators in the function of the epidermal-immune-neuro unit in the skin
Frontiers in Immunology, 2022 Skin is the largest, environmentally exposed (barrier) organ, capable of integrating various signals into effective defensive responses. The functional significance of interactions among the epidermis and the immune and nervous systems in regulating and ...
Ewa Oleszycka +8 more
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Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]
, 2003 To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim +5 more
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Chemokines, Chemokine Receptors, and Allograft Rejection [PDF]
Immunity, 2001 Chemokines are pivotal mediators in allograft rejection by virtue of their activity as regulators of leukocyte movement, adhesion, and effector function. Because the regulation of effector cell infiltration is complex, it is difficult to dissect the relative role of each chemokine in the inflammatory processes leading to allograft rejection, especially
Nelson, Peter J., Krensky, Alan M.
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