Results 41 to 50 of about 336,238 (316)

The complex nature of CXCR4 mutations in WHIM syndrome

Frontiers in Immunology
Heterozygous autosomal dominant mutations in the CXCR4 gene cause WHIM syndrome, a severe combined immunodeficiency disorder. The mutations primarily affect the C-terminal region of the CXCR4 chemokine receptor, specifically several potential ...
José Miguel Rodríguez-Frade, Luis Ignacio González-Granado, Luis Ignacio González-Granado, César A. Santiago, Mario Mellado   +4 more
doaj   +1 more source

Soluble mediators in the function of the epidermal-immune-neuro unit in the skin

Frontiers in Immunology, 2022
Skin is the largest, environmentally exposed (barrier) organ, capable of integrating various signals into effective defensive responses. The functional significance of interactions among the epidermis and the immune and nervous systems in regulating and ...
Ewa Oleszycka, Kamila Kwiecien, Patrycja Kwiecinska, Agnieszka Morytko, Natalia Pocalun, Michelle Camacho, Piotr Brzoza, Brian A. Zabel, Joanna Cichy   +8 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Nelson, EL, Nelson, P. J., Schlöndorff, D, C.D. Cohen, D. Schlöndorff, C.M. Klier, Horuk, R, P.J. Nelson, Schlöndorff, D., Klier, C. M., E.L. Nelson, Nelson, PJ, Cohen, CD, Horuk, R., Cohen, C. D., R. Horuk, Klier, CM, Nelson, E. L.   +17 more
core   +1 more source

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

eLife
CXCR4 is a ubiquitously expressed chemokine receptor that regulates leukocyte trafficking and arrest in both homeostatic and pathological states. It also participates in organogenesis, HIV-1 infection, and tumor development.
Eva M García-Cuesta, Pablo Martínez, Karthik Selvaraju, Gabriel Ulltjärn, Adrián Miguel Gómez Pozo, Gianluca D'Agostino, Sofia Gardeta, Adriana Quijada-Freire, Patricia Blanco Gabella, Carlos Roca, Daniel del Hoyo, Rodrigo Jiménez-Saiz, Alfonso García-Rubia, Blanca Soler Palacios, Pilar Lucas, Rosa Ayala-Bueno, Noelia Santander Acerete, Yolanda Carrasco, Carlos Oscar Sorzano, Ana Martinez, Nuria E Campillo, Lasse D Jensen, Jose Miguel Rodriguez Frade, César Santiago, Mario Mellado   +24 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes

, 2009
<p>Interleukin 17 (IL-17) is a proinflammatory cytokine, produced only by activated lymphocytes, but with a broad cellular host range. The effects of IL-17 on fibroblasts were investigated by analysis of the induction of chemokine and matrix ...
J. Hu, Zheng Qiu, Ghislain Opdenakker, Sofie Struyf, Jo Van Damme, G. Opdenakker, Chris Dillen, C. Dillen, Jialiang Hu, J. Van Damme, Hannelien Verbeke, S. Struyf, H. Verbeke, Z. Qiu   +13 more
core   +1 more source

Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice

Cells, 2021
It is important to investigate the sex-dependent roles of microglia in pain hypersensitivity as reactive microglia within the spinal dorsal horn (DH) have been reported to be pivotal in neuropathic pain induction in male rodents upon nerve injury.
Fumihiro Saika, Shinsuke Matsuzaki, Shiroh Kishioka, Norikazu Kiguchi   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish [PDF]

, 2016
Cxcl18b is a chemokine found in zebrafish and in other piscine and amphibian species. Cxcl18b is a reliable inflammatory marker; however, its function is yet to be elucidated.
Otto, N.A., Otto, Natasja A., Tavakoli-Tameh, A, Torraca, V, Torraca, V., Tavakoli-Tameh, A., Torraca, Vincenzo, Otto, NA, Otto, Natasja A, Meijer, Annemarie H, Meijer, Annemarie H., Meijer, AH, Tavakoli-Tameh, Aidin, Meijer, A.H.   +13 more
core   +1 more source