Results 11 to 20 of about 498,931 (351)
Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy
International Journal of Molecular Sciences, 2021 Chemokines are a large family of small chemotactic cytokines that coordinates immune cell trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the tumor, thereby shaping the tumor microenvironment immune profile,
Sandra Aguiar +2 more
exaly +2 more sources
Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy
Frontiers in Immunology, 2019 Immunotherapy is a clinically validated treatment for many cancers to boost the immune system against tumor growth and dissemination. Several strategies are used to harness immune cells: monoclonal antibodies against tumor antigens, immune checkpoint ...
Matteo Massara +2 more
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Immunity, 2019 Summary Despite compelling rates of durable clinical responses to PD-1 blockade, advances are needed to extend these benefits to resistant tumors. We found that tumor-bearing mice deficient in the chemokine receptor CXCR3 responded poorly to anti-PD-1 ...
Andrew Luster +2 more
exaly +2 more sources
Frontiers in Immunology, 2012 Chemoattractant cytokines or chemokines constitute a family of structurally related proteins found in vertebrates, bacteria or viruses. So far, 48 chemokines genes have been identified in humans, which bind to around 20 chemokine receptors.
Xavier eBLANCHET +4 more
doaj +4 more sources
Immunity, 2017 Summary CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120.
Irina Kufareva +2 more
exaly +2 more sources
Mechanisms of Regulation of the Chemokine-Receptor Network
International Journal of Molecular Sciences, 2017 The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection.
Jenni Hayward +2 more
exaly +2 more sources
Chemokine–Chemokine Receptors in Cancer Immunotherapy
Immunotherapy, 2008 A surge in interest in the chemokine-chemokine receptor network is probably related to the expanding roles that chemokines have now been identified to play in human biology, particularly immunity. Specific tissue microenvironments express distinct chemokines and both hematopoietic and nonhematopoietic cells have receptor expression profiles that permit
J. Stewart, Trina, J. Smyth, Mark
openaire +5 more sources
Frontiers in Immunology, 2022 Sphingolipids, ceramides and cholesterol are integral components of cellular membranes, and they also play important roles in signal transduction by regulating the dynamics of membrane receptors through their effects on membrane fluidity.
Sofía R. Gardeta +12 more
doaj +1 more source
Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
eLife, 2022 Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding of how chemokines ...
Laura Medina-Ruiz +12 more
doaj +1 more source
Frontiers in Immunology, 2022 Follicular T cells including T follicular helper (TFH) and T follicular regulatory (TFR) cells are essential in supporting and regulating the quality of antibody responses that develop in the germinal centre (GC).
Cameron R. Bastow +5 more
doaj +1 more source