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Frontiers in Immunology, 2012 Chemoattractant cytokines or chemokines constitute a family of structurally related proteins found in vertebrates, bacteria or viruses. So far, 48 chemokines genes have been identified in humans, which bind to around 20 chemokine receptors.
Xavier eBLANCHET +4 more
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Chemokine–Chemokine Receptors in Cancer Immunotherapy
Immunotherapy, 2008 A surge in interest in the chemokine-chemokine receptor network is probably related to the expanding roles that chemokines have now been identified to play in human biology, particularly immunity. Specific tissue microenvironments express distinct chemokines and both hematopoietic and nonhematopoietic cells have receptor expression profiles that permit
J. Stewart, Trina, J. Smyth, Mark
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2015 It is now well appreciated that chemokines play a fundamental role in various aspects of CVDs (Figure). Although numerous features of chemokine biology in relation to CVD remain to be elucidated, recent studies including those published i ATVB and highlighted herein have substantially contributed to our current knowledge on chemokines.
van der Vorst, Emiel P. C. +2 more
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Mouse CCL9 Chemokine Acts as Tumor Suppressor in a Murine Model of Colon Cancer
Current Issues in Molecular Biology, 2023 Colorectal cancer is the third most frequently diagnosed cancer in the world. Despite extensive studies and apparent progress in modern strategies for disease control, the treatment options are still not sufficient and effective, mostly due to frequently
Marzena Łazarczyk +7 more
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Chemokines and chemokine receptors in arthritis [PDF]
Frontiers in Bioscience, 2010 Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines.
Zoltan, Szekanecz +3 more
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Chemokines: What chemokine is that? [PDF]
Current Biology, 1997 The discovery of a new and unusual member of the chemokine family illustrates the importance of chemoattractant diversity in the regulation of leukocyte movement through the body. The chemokines are now divisible into four clearly defined subgroups on the basis of structural and functional properties.
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Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]
, 2010 Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Sayyed, Sufyan Ali +2 more
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Chemokine Receptors and Phagocyte Biology in Zebrafish. [PDF]
, 2020 Phagocytes are highly motile immune cells that ingest and clear microbial invaders, harmful substances, and dying cells. Their function is critically dependent on the expression of chemokine receptors, a class of G-protein-coupled receptors (GPCRs ...
Sommer, F. +6 more
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Chemokines and chemokine receptors: an overview
Frontiers in Bioscience, 2009 Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling ...
R. Bonecchi +5 more
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Chemokine receptor CCR1: A new target for progressive kidney disease [PDF]
, 2005 Infiltrating leukocytes are thought to contribute to the progression of kidney disease. Locally produced chemokines guide circulating leukocytes into the kidney, which renders therapeutic blockade of respective chemokine receptors on the leukocyte ...
Hans-Joachim Anders +3 more
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