Chemokines and chemokine receptors: A new strategy for breast cancer therapy
Cancer Medicine, 2020 Chemokines and chemokine receptors not only participate in the development of tissue differentiation, hematopoiesis, inflammation, and immune regulation but also play an important role in the process of tumor development.
Hui Liu +8 more
doaj +2 more sources
PET Imaging Radiotracers of Chemokine Receptors [PDF]
Molecules, 2021 Chemokines and chemokine receptors have been recognized as critical signal components that maintain the physiological functions of various cells, particularly the immune cells.
Santosh R. Alluri +2 more
doaj +2 more sources
Chemokines and chemokine receptors in Behçet's disease. [PDF]
Front Immunol, 2023 Behçet’s disease (BD), a chronic vascular inflammatory disease, is characterized by the symptoms of ocular lesions, recurrent genital and oral ulcers, skin symptoms and arthritis in addition to neurological, intestinal and vascular involvement. The pathogenesis of BD is poorly understood, and there are no effective laboratory markers for the diagnosis ...
Li Z, Cheng L, Zhan H, Li Y.
europepmc +4 more sources
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3 [PDF]
Cell Discovery, 2022 Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao +21 more
doaj +2 more sources
Differential expression of chemokine receptors on monocytes in TB and HIV S [PDF]
Heliyon, 2023 In the present study, we defined multiple chemokine receptors expressed by classical, intermediate and non-classical monocyte subsets in TB, HIV and TB/HIV co-infection and associate it with the perturbation of monocyte subsets due to the diseases ...
Wegene Tamene +7 more
doaj +2 more sources
CC chemokine receptors are prognostic indicators of gastric cancer and are associated with immune infiltration [PDF]
BMC Medical GenomicsBackground CC chemokine receptors are responsible for regulating the tumor microenvironment (TME) and participating in carcinogenesis and tumor advancement.
Xinghe Liao +4 more
doaj +2 more sources
Chemokines and chemokine receptors in CNS pathology [PDF]
Journal of NeuroVirology, 1999 Chemokines are small proinflammatory cytokineswhich stimulate migration of inflammatory cells invitro and in vivo. They can be divided according tostructure, function and gene localization into fourdifferent subfamilies. Chemokines have been as-cribed diverse additional functions, including reg-ulation of angiogenesis, control of cell proliferationand ...
Andrzej R Glabinski, Richard M Ransohoff
exaly +3 more sources
Chemokines and Chemokine Receptors in Multiple Sclerosis [PDF]
Mediators of Inflammation, 2014 Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain ...
Wenjing Cheng, Guangjie Chen
doaj +3 more sources
Biased agonism at chemokine receptors [PDF]
Cellular Signalling, 2021 Dylan Scott Eiger +2 more
exaly +2 more sources
Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]
PLoS Computational Biology, 2018 Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer +2 more
doaj +1 more source