Role of Atypical Chemokine Receptors in Microglial Activation and Polarization [PDF]
Frontiers in Aging Neuroscience, 2017 Inflammatory reactions occurring in the central nervous system (CNS), known as neuroinflammation, are key components of the pathogenic mechanisms underlying several neurological diseases.
Valentina Salvi +6 more
doaj +9 more sources
Atlas of the anatomical localization of atypical chemokine receptors in healthy mice. [PDF]
PLoS Biology, 2023 Atypical chemokine receptors (ACKRs) scavenge chemokines and can contribute to gradient formation by binding, internalizing, and delivering chemokines for lysosomal degradation.
Serena Melgrati +8 more
doaj +3 more sources
The Role of Atypical Chemokine Receptors in Neuroinflammation and Neurodegenerative Disorders. [PDF]
Int J Mol Sci, 2023 Lindsay HG +4 more
europepmc +5 more sources
GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity [PDF]
Frontiers in Immunology, 2023 Immune responses highly depend on the effective trafficking of immune cells into and within secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge chemokines to eliminate them from the extracellular space, thereby generating ...
Serena Melgrati +16 more
doaj +2 more sources
Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response. [PDF]
Front Immunol, 2016 Bonecchi R, Graham GJ.
europepmc +5 more sources
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides [PDF]
Nature Communications, 2020 Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating ...
Max Meyrath +13 more
doaj +2 more sources
MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2 [PDF]
, 2018 Chemokines are the principal regulators of leukocyte migration and are essential for initiation and maintenance of inflammation. Atypical chemokine receptor 2 (ACKR2) binds and scavenges proinflammatory CC-chemokines, regulates cutaneous T-cell ...
Burden, AD +5 more
core +4 more sources
Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell chronic lymphocytic leukemia [PDF]
Molecular Cancer, 2010 Background The non-signalling chemokine receptors, including receptors DARC, D6 and CCX-CKR, have recently been shown to be involved in chemokine clearance and activity regulation.
Buchner Maike V +6 more
doaj +4 more sources
The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
core +3 more sources
Potential combinatorial effects of recombinant atypical chemokine receptors in breast cancer cell invasion: A research perspective. [PDF]
Biomed Rep, 2013 Chew AL, Tan WY, Khoo BY.
europepmc +3 more sources