Results 1 to 10 of about 2,928 (195)

Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway

Cells
The reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through multiple
Xiaoming Wu, Hua Jin
exaly   +7 more sources

Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue [PDF]

Biomedicines, 2021
Dysfunctional adipose tissue (AT) may contribute to the pathology of several metabolic diseases through altered lipid metabolism, insulin resistance, and inflammation.
Christian Weber, Emiel van der Vorst, Yvonne Döring   +2 more
exaly   +10 more sources

Marginal Zone Formation Requires ACKR3 Expression on B Cells

Cell Reports, 2020
Summary: The marginal zone (MZ) contributes to the highly organized spleen microarchitecture. We show that expression of atypical chemokine receptor 3 (ACKR3) defines two equal-sized populations of mouse MZ B cells (MZBs).
Marcus Thelen, Serena Melgrati, David Jarrossay   +2 more
exaly   +7 more sources

Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells. [PDF]

PLoS ONE, 2023
Atypical chemokine receptor 3 (ACKR3) is a scavenger of the chemokines CXCL11 and CXCL12 and of several opioid peptides. Additional evidence indicates that ACKR3 binds two other non-chemokine ligands, namely the peptide hormone adrenomedullin (AM) and ...
Elena C Sigmund, Aline Bauer, Barbara D Jakobs, Hazal Tatliadim, Carlotta Tacconi, Marcus Thelen, Daniel F Legler, Cornelia Halin   +7 more
doaj   +8 more sources

Pharmacological modulation of CXCL12/CXCR4/ACKR3 for brain disorders – an overview [PDF]

Cell Communication and Signaling
The CXCL12/CXCR4/ACKR3 axis is essential for brain development and homeostasis. Dysregulation of CXCL12 or its receptors has been associated with various CNS disorders related to neurodevelopmental defects, neuroinflammation, neurodegeneration and brain ...
Amandine Kuppens, Bernard Rogister, Virginie Neirinckx   +2 more
doaj   +3 more sources

Single-cell transcriptomics identifies a putative perivascular macrophage–endothelial MIF–ACKR3 axis associated with endothelial activation in acute traumatic brain injury [PDF]

Frontiers in Cellular Neuroscience
BackgroundBlood–brain barrier (BBB) disruption is a hallmark of acute traumatic brain injury (TBI), yet the immune–vascular mechanisms underlying endothelial dysfunction remain incompletely understood.
Yanya Lin, Yanya Lin, Chengda Lin, Jianhui Chen, Shijun Chen, Jianhuang Huang, Jianxiong Hu   +6 more
doaj   +3 more sources

FTO-ACKR3 Axis Regulates Polycyclic Aromatic Hydrocarbons-Induced Asthma Attacks via AhR-Mediated m⁶A RNA Methylation. [PDF]

Environ Health (Wash)
Airborne polycyclic aromatic hydrocarbons (PAHs) are increasingly linked to asthma onset and exacerbation, yet their molecular mechanisms remain unclear.
Liu S, Chu J, Xin J, Yin X, He Z, Qin S, Song X.   +6 more
europepmc   +2 more sources

Endothelial Atypical Receptors for Chemoattractants in Lung Immune Surveillance. [PDF]

Eur J Immunol
Control of chemokine gradients within tissues is achieved by atypical chemokine receptors (ACKRs). The lungs require tightly regulated leukocyte recruitment for effective host defense while preventing tissue damage. In this context, ACKRs expressed by lung endothelial cells are emerging as critical regulators of leukocyte trafficking and inflammatory ...
Laffranchi M, Bonanni E, Sozio F, Turchetti M, Sciumè G, Thelen M, Prete AD, Bonecchi R, Sozzani S.   +8 more
europepmc   +2 more sources

Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single-cell and bulk transcriptomic analysis. [PDF]

J Cell Commun Signal
Integrative single‐cell and bulk transcriptomic analyses identified a highly inflammatory macrophage state and a vascular smooth muscle cell (VSMC) remodeling continuum in human atherosclerotic plaques. Candidate ligand‐receptor and ligand‐associated target gene expression patterns linked inflammatory macrophage activation with osteogenic/modulated ...
Dong X, Hu X, Liu Q, Dong Y, Xuan Y, Wang M, Chang S, Lu T, Han Z.   +8 more
europepmc   +2 more sources

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies [PDF]

Nature Communications
Stimulation of atypical chemokine receptor 3 (ACKR3) by chemokines does not activate G proteins but recruits arrestin. It is a chemokine scavenger that indirectly influences responses by restricting the availability of CXCL12, an agonist shared with the ...
Claudia V. Perez Almeria, Omolade Otun, Roman Schlimgen, Thomas D. Lamme, Lotte Di Niro, Caitrin Crudden, Jan Paul Bebelman, Noureldine Youssef, Lejla Musli, Shawn Jenjak, Vladimir Bobkov, Julia Drube, Carsten Hoffmann, Brian F. Volkman, Sébastien Granier, Cherine Bechara, Marco Siderius, Raimond Heukers, Christopher T. Schafer, Martine J. Smit   +19 more
doaj   +2 more sources