Results 1 to 10 of about 3,160 (160)

ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production [PDF]

Frontiers in Immunology, 2023
Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers.
Serena Melgrati, Marcus Thelen
exaly   +5 more sources

Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway [PDF]

Cells
The reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through multiple
Zelong Ma, Faxiao Zhou, Hua Jin, Xiaoming Wu   +3 more
exaly   +4 more sources

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies [PDF]

Nature Communications
Stimulation of atypical chemokine receptor 3 (ACKR3) by chemokines does not activate G proteins but recruits arrestin. It is a chemokine scavenger that indirectly influences responses by restricting the availability of CXCL12, an agonist shared with the ...
Claudia V. Perez Almeria, Omolade Otun, Roman Schlimgen, Thomas D. Lamme, Lotte Di Niro, Caitrin Crudden, Jan Paul Bebelman, Noureldine Youssef, Lejla Musli, Shawn Jenjak, Vladimir Bobkov, Julia Drube, Carsten Hoffmann, Brian F. Volkman, Sébastien Granier, Cherine Bechara, Marco Siderius, Raimond Heukers, Christopher T. Schafer, Martine J. Smit   +19 more
doaj   +3 more sources

D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling [PDF]

EBioMedicine, 2021
Background: Emphysematous COPD is characterized by aberrant alveolar repair. Macrophage migration inhibitory factor (MIF) contributes to alveolar repair, but for its structural and functional homolog D-dopachrome tautomerase (DDT) this is unknown.
Shanshan Song, Bin Liu, Habibie Habibie, Jelle van den Bor, Martine J. Smit, Reinoud Gosens, Xinhui Wu, Corry-Anke Brandsma, Robbert H. Cool, Hidde J. Haisma, Gerrit J. Poelarends, Barbro N. Melgert   +11 more
doaj   +3 more sources

Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization

Cells, 2021
Background: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate G proteins in most cell types but recruits β-arrestins upon activation. ACKR3
Claudia V Perez Almeria, Jelle van den Bor, Jan Paul M Bebelman   +2 more
exaly   +3 more sources

ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury

Nature Communications, 2022
ACKR3 is a critical regulator of platelet-mediated thrombosis and organ injury following ischemia/reperfusion. Platelet ACKR3 surface expression is independently associated with all-cause mortality in patients with cardiovascular diseases.
Anne-Katrin Rohlfing, Kyra Kolb, Manuel Sigle   +2 more
exaly   +2 more sources

Marginal Zone Formation Requires ACKR3 Expression on B Cells

Cell Reports, 2020
Summary: The marginal zone (MZ) contributes to the highly organized spleen microarchitecture. We show that expression of atypical chemokine receptor 3 (ACKR3) defines two equal-sized populations of mouse MZ B cells (MZBs).
Serena Melgrati, Marcus Thelen
exaly   +3 more sources

Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes [PDF]

eLife
The canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration.
Christopher T Schafer, Raymond F Pauszek III, Martin Gustavsson, Tracy M Handel, David P Millar   +4 more
doaj   +2 more sources

Structural basis of ligand interaction with atypical chemokine receptor 3 [PDF]

Nature Communications, 2017
The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and ...
Martin Gustavsson, Liwen Wang, Noortje van Gils, Bryan S. Stephens, Penglie Zhang, Thomas J. Schall, Sichun Yang, Ruben Abagyan, Mark R. Chance, Irina Kufareva, Tracy M. Handel   +10 more
doaj   +3 more sources

Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases

Frontiers in Endocrinology, 2022
Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular diseases (CVD). Chemokines classically mediate their effects by binding to G-protein-coupled receptors.
Vincent Duval, Paul Alayrac, Jean-Sebastien Silvestre   +2 more
exaly   +3 more sources