Results 1 to 10 of about 54,287 (259)

Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy

Current Medicinal Chemistry, 2019
Chemokines, which have chemotactic abilities, are comprised of a family of small cytokines with 8–10 kilodaltons. Chemokines work in immune cells by trafficking and regulating cell proliferation, migration, activation, differentiation, and homing. CXCR-4
Mingli Liu, Matthew Burow, Guangdi Wang   +2 more
exaly   +2 more sources

The CXCL12 Crossroads in Cancer Stem Cells and Their Niche [PDF]

Cancers, 2021
Simple Summary CXCL12 and its receptors have been extensively studied in cancer, including their influence on cancer stem cells (CSCs) and their niche.
J. C. López-Gil, L. Martin-Hijano, P. Hermann, B. Sáinz   +3 more
semanticscholar   +6 more sources

The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention

Cellular & Molecular Immunology, 2023
Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes. CXCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to ...
S. Cambier, Mieke Gouwy, P. Proost
semanticscholar   +1 more source

CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications

International Journal on Biological Sciences, 2023
Cancer is a multi-step disease caused by the accumulation of genetic mutations and/or epigenetic changes, and is the biggest challenge around the world. Cytokines, including chemokines, exhibit expression changes and disorders in all human cancers. These
Yaru Yang, Jiayan Li, Wangrui Lei, Haiying Wang, Yun-feng Ni, Yanqing Liu, Huanle Yan, Yifan Tian, Zheng Wang, Zhi Yang, Shulin Yang, Yang Yang, Qiang Wang   +12 more
semanticscholar   +1 more source

Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1

Journal of experimental & clinical cancer research : CR, 2023
Background Cancer-associated fibroblasts (CAFs), the predominant stromal cell of tumor microenvironment (TME), play an important role in tumor progression and immunoregulation by remodeling extracellular matrix (ECM) and secreting cytokines.
Zhao Zhang, Yongbo Yu, Zhilei Zhang, Dan Li, Zhijuan Liang, Liping Wang, Yuanbin Chen, Ye Liang, Haitao Niu   +8 more
semanticscholar   +1 more source

An emerging paradigm of CXCL12 involvement in the metastatic cascade.

Cytokine & growth factor reviews, 2023
The chemokine CXCL12, also known as stromal cell-derived factor 1 (SDF1), has emerged as a pivotal regulator in the intricate molecular networks driving cancer progression.
Dimitra P. Anastasiadou, A. Quesnel, Camille L. Duran, Panagiota S. Filippou, G. Karagiannis   +4 more
semanticscholar   +1 more source

CXCR4/CXCL12 Activities in the Tumor Microenvironment and Implications for Tumor Immunotherapy

Cancers, 2022
Simple Summary Chemokines are small soluble proteins that control and regulate cell trafficking within and between tissues by binding to their receptors.
R. Mezzapelle, Manuela Leo, Francesca Caprioglio, L. Colley, Andrea Lamarca, L. Sabatino, V. Colantuoni, M. Crippa, M. Bianchi   +8 more
semanticscholar   +1 more source

Ebf3+ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells

Nature Communications, 2023
Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors.
Taichi Nakatani, Tatsuki Sugiyama, Y. Omatsu, Hitomi Watanabe, Gen Kondoh, Takashi Nagasawa   +5 more
semanticscholar   +1 more source

Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer

Molecular Cancer, 2022
Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression and dissemination. Insight in cell-to-cell communication networks provides new therapeutic avenues to mold processes that contribute to PCa tumor microenvironment ...
I. Heidegger, G. Fotakis, A. Offermann, J. Goveia, S. Daum, S. Salcher, A. Noureen, H. Timmer‐Bosscha, G. Schäfer, A. Walenkamp, S. Perner, Aleksandar Beatovic, M. Moisse, C. Plattner, A. Krogsdam, J. Haybaeck, S. Sopper, S. Thaler, M. Keller, H. Klocker, Z. Trajanoski, D. Wolf, A. Pircher   +22 more
semanticscholar   +1 more source

Ketogenesis attenuates KLF5-dependent production of CXCL12 to overcome the immunosuppressive tumor microenvironment in colorectal cancer

Cancer Research, 2022
The dynamic composition of the tumor microenvironment (TME) can markedly alter the response to targeted therapies for colorectal cancer (CRC). Cancer associated fibroblasts (CAF) are major components of TMEs that can direct and induce infiltration of ...
Ruozheng Wei, Yuning Zhou, Chang Li, P. Rychahou, Shulin Zhang, W. Titlow, Greg Bauman, Yuanyuan Wu, Jinpeng Liu, Chi Wang, H. Weiss, B. Evers, Qingding Wang   +12 more
semanticscholar   +1 more source