Regulation of the Chemokine Receptor CXCR4 by Hypoxia [PDF]
Journal of Experimental Medicine, 2003 Cell adaptation to hypoxia (Hyp) requires activation of transcriptional programs that coordinate expression of genes involved in oxygen delivery (via angiogenesis) and metabolic adaptation (via glycolysis). Here, we describe that oxygen availability is a determinant parameter in the setting of chemotactic responsiveness to stromal-derived factor 1 ...
Alberto Mantovani +2 more
exaly +8 more sources
Regulation of the chemokine receptors CXCR4 and ACKR3 by receptor activity-modifying proteins. [PDF]
J Biol ChemThe chemokine CXCL12 and its two cognate receptors-CXCR4 and ACKR3-are key players in various homeostatic and pathophysiological processes, including embryonic development, autoimmune diseases, tissue repair, and cancer. Recent reports identified an interaction of CXCR4 and ACKR3 with receptor activity-modifying proteins (RAMPs), and RAMP3 has been ...
Pfersdorf F +3 more
europepmc +5 more sources
Pharmacological modulation of CXCL12/CXCR4/ACKR3 for brain disorders – an overview [PDF]
Cell Communication and SignalingThe CXCL12/CXCR4/ACKR3 axis is essential for brain development and homeostasis. Dysregulation of CXCL12 or its receptors has been associated with various CNS disorders related to neurodevelopmental defects, neuroinflammation, neurodegeneration and brain ...
Amandine Kuppens +2 more
doaj +2 more sources
Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor
Frontiers in Molecular Biosciences, 2022 Chemokine receptors are key G-protein-coupled receptors (GPCRs) that control cell migration in immune system responses, development of cardiovascular and central nervous systems, and numerous diseases. In particular, the CXCR4 chemokine receptor promotes
Shristi Pawnikar, Yinglong Miao
doaj +1 more source
Role and implications of the CXCL12/CXCR4/CXCR7 axis in atherosclerosis: still a debate
Annals of Medicine, 2021 Atherosclerosis is one of the leading causes of mortality and morbidity worldwide. Chemokines and their receptors are implicated in the pathogenesis of atherosclerosis.
Hussam A. S. Murad +2 more
doaj +1 more source
Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]
PLoS Computational Biology, 2018 Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer +2 more
doaj +1 more source
Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes. [PDF]
PLoS ONE, 2010 The entry of human immunodeficiency virus (HIV-1) into host cells involves the interaction of the viral exterior envelope glycoprotein, gp120, and receptors on the target cell. The HIV-1 receptors are CD4 and one of two chemokine receptors, CCR5 or CXCR4.
Mikhail A Zhukovsky +6 more
doaj +1 more source
BMC Complementary Medicine and Therapies, 2022 Background The chemokine CXCL12 and its two receptors (CXCR4 and CXCR7) are involved in inflammation and hematopoietic cell trafficking. This study was designed to investigate molecular docking interactions of four popular cardiovascular-active natural ...
Hussam Aly Sayed Murad +2 more
doaj +1 more source
The CXCR4/CXCR7/CXCL12 Axis Is Involved in a Secondary but Complex Control of Neuroblastoma Metastatic Cell Homing. [PDF]
PLoS ONE, 2015 Neuroblastoma (NB) is one of the most deadly solid tumors of the young child, for which new efficient and targeted therapies are strongly needed. The CXCR4/CXCR7/CXCL12 chemokine axis has been involved in the progression and organ-specific dissemination ...
Annick Mühlethaler-Mottet +8 more
doaj +1 more source
Molecular Imaging of Chemokine Receptor CXCR4 [PDF]
Theranostics, 2013 CXCR4 was found to be expressed by many different types of human cancers and its expression has been correlated with tumor aggressiveness, poor prognosis and resistance to chemotherapy. CXCR4 was also shown to contribute to metastatic seeding of organs that express its ligand CXCL12 and support the survival of these cells.
Weiss, Ido. D., Jacobson, Orit
openaire +4 more sources