Results 11 to 20 of about 49,164 (249)
Structural basis of dimerization of chemokine receptors CCR5 and CXCR4
Nature Communications, 2023 G protein-coupled receptors (GPCRs) are prominent drug targets responsible for extracellular-to-intracellular signal transduction. GPCRs can form functional dimers that have been poorly characterized so far.
Daniele Di Marino +3 more
doaj +5 more sources
Molecular Imaging of Chemokine Receptor CXCR4 [PDF]
Theranostics, 2013 CXCR4 was found to be expressed by many different types of human cancers and its expression has been correlated with tumor aggressiveness, poor prognosis and resistance to chemotherapy. CXCR4 was also shown to contribute to metastatic seeding of organs that express its ligand CXCL12 and support the survival of these cells.
Weiss, Ido. D., Jacobson, Orit
openaire +4 more sources
Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3. [PDF]
Cytokine, 2018 Chemokines are named and best known for their chemotactic cytokine activity in the hematopoietic system; however, their importance extends far beyond leukocytes, cell movement and immunoregulation. CXCL12, the most protean of chemokines, regulates development in multiple systems, including the hematopoietic, cardiovascular and nervous systems, and ...
Murphy PM, Heusinkveld L.
europepmc +4 more sources
Regulation of the chemokine receptors CXCR4 and ACKR3 by receptor activity-modifying proteins. [PDF]
J Biol ChemThe chemokine CXCL12 and its two cognate receptors-CXCR4 and ACKR3-are key players in various homeostatic and pathophysiological processes, including embryonic development, autoimmune diseases, tissue repair, and cancer. Recent reports identified an interaction of CXCR4 and ACKR3 with receptor activity-modifying proteins (RAMPs), and RAMP3 has been ...
Pfersdorf F +3 more
europepmc +5 more sources
Regulation of the Chemokine Receptor CXCR4 by Hypoxia [PDF]
The Journal of Experimental Medicine, 2003 Cell adaptation to hypoxia (Hyp) requires activation of transcriptional programs that coordinate expression of genes involved in oxygen delivery (via angiogenesis) and metabolic adaptation (via glycolysis). Here, we describe that oxygen availability is a determinant parameter in the setting of chemotactic responsiveness to stromal-derived factor 1 ...
T. Schioppa +12 more
openaire +5 more sources
Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma. [PDF]
PLoS ONE, 2012 Neuroblastoma (NB) is a typical childhood and heterogeneous neoplasm for which efficient targeted therapies for high-risk tumors are not yet identified.
Julie Liberman +8 more
doaj +1 more source
Antibodies Targeting Chemokine Receptors CXCR4 and ACKR3 [PDF]
Molecular Pharmacology, 2019 Dysregulation of the chemokine system is implicated in a number of autoimmune and inflammatory diseases, as well as cancer. Modulation of chemokine receptor function is a very promising approach for therapeutic intervention. Despite interest from academic groups and pharmaceutical companies, there are currently few approved medicines targeting ...
Bobkov, Vladimir +6 more
openaire +4 more sources
CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7. [PDF]
PLoS ONE, 2014 Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as pathogenesis of other common diseases. CXCL12 binds two different receptors, CXCR4 and CXCR7, both of which recruit and signal through the cytosolic ...
Nathaniel L Coggins +7 more
doaj +1 more source
Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors. [PDF]
PLoS ONE, 2008 BACKGROUND: Dimerization has emerged as an important feature of chemokine G-protein-coupled receptors. CXCR4 and CCR5 regulate leukocyte chemotaxis and also serve as a co-receptor for HIV entry.
Nilgun Isik, Dale Hereld, Tian Jin
doaj +1 more source
Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer [PDF]
International Journal of Molecular Sciences, 2020 Background: The mortality rate of pancreatic cancer (PC) is equal to its incidence and the majority of PC patients die within a few months of diagnosis. Therefore, a search for new biomarkers useful in the diagnosis and prognosis of PC is ongoing.
Ala Litman-Zawadzka +5 more
openaire +2 more sources