Results 31 to 40 of about 599,394 (294)

Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells. [PDF]

PLoS ONE, 2013
The G-protein coupled receptor (GPCR), Cysteine (C)-X-C Receptor 4 (CXCR4), plays an important role in prostate cancer metastasis. CXCR4 is generally regarded as a plasma membrane receptor where it transmits signals that support transformation ...
Ayesha S Don-Salu-Hewage, Siu Yuen Chan, Kathleen M McAndrews, Mahandranauth A Chetram, Michelle R Dawson, Danaya A Bethea, Cimona V Hinton   +6 more
doaj   +1 more source

CRISPR-Cas9-mediated gene disruption of HIV-1 co-receptors confers broad resistance to infection in human T cells and humanized mice

Molecular Therapy: Methods & Clinical Development, 2022
In this preclinical study, we evaluated the efficacy and feasibility of creating broad human immunodeficiency virus (HIV) resistance by simultaneously disrupting the human CCR5 and CXCR4 genes, which encode cellular co-receptors required for HIV-1 ...
Shasha Li, Leo Holguin, John C. Burnett
doaj   +1 more source

Intravesical CD74 and CXCR4, macrophage migration inhibitory factor (MIF) receptors, mediate bladder pain.

PLoS ONE, 2021
BackgroundActivation of intravesical protease activated receptor 4 (PAR4) leads to release of urothelial macrophage migration inhibitory factor (MIF). MIF then binds to urothelial MIF receptors to release urothelial high mobility group box-1 (HMGB1) and ...
Shaojing Ye, Fei Ma, Dlovan F D Mahmood, Katherine L Meyer-Siegler, Raymond E Menard, David E Hunt, Lin Leng, Richard Bucala, Pedro L Vera   +8 more
doaj   +1 more source

Expression of CXCR4 on feline peripheral blood mononuclear cells: effect of feline immunodeficiency virus infection. [PDF]

, 2003
CXCR4 expression on feline peripheral blood mononuclear cells (PBMC) was analyzed. While monocytes and B lymphocytes expressed CXCR4, no CXCR4 was detected on T lymphocytes, in stark contrast to the expression pattern on T lymphocytes from humans.
Hosie, M.J., Willett, B.J., Cannon, C.A.
core   +1 more source

Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue [PDF]

, 2004
Identification of cellular factors involved in HIV-1 entry and transmission at mucosal surfaces is critical for understanding viral pathogenesis and development of effective prevention strategies. Here we describe the evaluation of HIV-1 entry inhibitors
Ines Frank, Griffin, GE, Griffin, George E., George E. Griffin, Santos, John J., John P. Moore, Robin J. Shattock, Shattock, Robin J., Watts, Patricia, John J. Santos, Patricia Watts, Santos, JJ, Shattock, RJ, Vennansha Williams, Williams, V, Moore, JP, Williams, Vennansha G., Robbiani, Melissa, Hu, Qinxue, Qinxue Hu, Pope, M, Melissa Pope, Moore, John P., Frank, Ines, Hu, Q, Frank, I, Watts, P   +26 more
core   +1 more source

Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer [PDF]

International Journal of Molecular Sciences, 2020
Background: The mortality rate of pancreatic cancer (PC) is equal to its incidence and the majority of PC patients die within a few months of diagnosis. Therefore, a search for new biomarkers useful in the diagnosis and prognosis of PC is ongoing.
Ala Litman-Zawadzka, Marta Łukaszewicz-Zając, Mariusz Gryko, Agnieszka Kulczyńska-Przybik, Bogusław Kędra, Barbara Mroczko   +5 more
openaire   +2 more sources

Somatostatin Receptors and Chemokine Receptor CXCR4 in Lymphomas: A Histopathological Review of Six Lymphoma Subtypes

Frontiers in Oncology, 2021
BackgroundSomatostatin receptors (SSTR) and chemokine receptor CXCR4 are expressed in lymphomas, while the abundance is known to be heterogeneous in different subtypes of lymphomas.
Tiina Juntikka, Samuli Vaittinen, Tero Vahlberg, Sirkku Jyrkkiö, Heikki Minn   +4 more
doaj   +1 more source

CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]

, 2010
CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is
Pruenster, M, Mahabaleshwar, Harsha, Ulrike Naumann, Raz Erez, Rot, Antal, Rot Antal, Marcus Thelen, Naumann, U, Zerwes Hans-Günter, Harsha Mahabaleshwar, Naumann Ulrike, Cameroni, E, Mahabaleshwar, H, Elisabetta Cameroni, Zerwes, Hans-Günter, Raz, E, Pruenster Monika, Mahabaleshwar Harsha, Monika Pruenster, Hans-Günter Zerwes, Pruenster, Monika, Thelen, M, Thelen Marcus, Naumann, Ulrike, Cameroni, Elisabetta, Cameroni Elisabetta, Raz, Erez, Zerwes, HG, Antal Rot, Erez Raz, Thelen, Marcus   +30 more
core   +1 more source

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor [PDF]

, 2013
Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation.
Dembowsky, K., Dembowsky, Klaus, Romagnoli, B., G Spohn, Karpova, Darja, Patel, K., Chevalier, E., Levesque, J. P., E Chevalier, D Karpova, Patel, Kalpana, Spohn, Gabriele, Romagnoli, Barbara, Schulz, M., Wiercinska, Eliza, Chevalier, Eric, H Bonig, K Dauber, E Wiercinska, J P Levesque, Schulz, Miriam, Chudziak, D., K Dembowsky, Dauber, Katrin, Karpova, D., B Romagnoli, A R Pettit, Wiercinska, E., D Chudziak, Levesque, Jean-Pierre, Bönig, Halvard-Björn, Spohn, G., Pettit, Allison R., M Schulz, K Patel, Bonig, H., Pettit, A. R., Chudziak, Doreen, Dauber, K.   +38 more
core   +1 more source

Clinical relevance of chemokine receptor CXCR4

Postępy Higieny i Medycyny Doświadczalnej, 2012
 Stromal cell-derived factor-1 (SDF-1/CXCL12) induces intracellular signaling pathways crucial for mobilization, migration, proliferation and survival of many cell types via CXCR4, a chemokine CXC-motif receptor, member of the G protein-coupled receptor family.
Katarzyna, Gębura, Katarzyna, Bogunia-Kubik   +1 more
openaire   +2 more sources