Results 21 to 30 of about 599,394 (294)
Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system
Nature Communications, 2023 Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms.
Parishmita Sarma +16 more
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CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa
Open Life Sciences, 2023 CXCR4 and CXCR7 have been revealed to be receptors of CXCL12. This research was designed to probe the expression of chemokine CXCL12 and its receptors CXCR4 and CXCR7 in placental tissues of patients with placenta previa and the effect of CXCL12/CXCR4 ...
Wu Xia, Wang Ying, Li Min
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Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver Disease
Frontiers in Cell and Developmental Biology, 2021 Chemokine receptors are members of the G protein-coupled receptor superfamily, which together with chemokine ligands form chemokine networks to regulate various cellular functions, immune and physiological processes.
Sheng Wang +6 more
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Solubilization of the Chemokine Receptor CXCR4
Biochemical and Biophysical Research Communications, 2000 The chemokine receptor CXCR4 was solubilized from the human T-cell line CEM by using the detergent n-dodecyl-beta-maltoside (DDM) and cholesteryl hemisuccinate ester (CHS). Binding studies with (125)I-SDF-1alpha revealed a dissociation constant of 5.33 nM and a receptor density (B(max)) of 2.68 pmol/mg in CEM membranes at 4 degrees C.
R, Staudinger, J C, Bandres
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Agonists for the Chemokine Receptor CXCR4
ACS Medicinal Chemistry Letters, 2011 The development of agonists for the chemokine receptor CXCR4 could provide promising therapeutic candidates. On the basis of previously forwarded two site model of chemokine-receptor interactions, we hypothesized that linking the agonistic N-terminus of SDF-1 to the T140 backbone would yield new high-affinity agonists of CXCR4.
Lefrançois, Marilou +8 more
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The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases
Frontiers in Endocrinology, 2019 Chemokine receptors are members of the G protein-coupled receptor superfamily. These receptors are intimately involved in cell movement, and thus play a critical role in several physiological and pathological situations that require the precise ...
Eva M. García-Cuesta +5 more
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Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus [PDF]
, 2002 Feline CXCR4 and CCR5 were expressed in feline cells as fusion proteins with enhanced green fluorescent protein (EGFP). Expression of the EGFP fusion proteins was localized to the cell membrane, and surface expression of CXCR4 was confirmed by using a ...
Hosie, M.J., Willett, B.J., Cannon, C.A.
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The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus [PDF]
, 1999 Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting ...
Hosie, M.J. +3 more
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Frontiers in Cell and Developmental Biology, 2020 Trypanosoma cruzi P21 is a protein secreted by the parasite that plays biological roles directly involved in the progression of Chagas disease. The recombinant protein (rP21) demonstrates biological properties, such as binding to CXCR4 receptors in ...
Bruna Cristina Borges +15 more
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Stromal cell derived factor-1, CXCR4 and CXCR7 gene transcripts in pterygia
Journal of Current Ophthalmology, 2017 Purpose: Pterygium is a pathologic process with angiogenic and tumor cell like characteristics. Chemokine and chemokine receptors may contribute to the formation and growth of pterygia.
Shahram Bamdad +4 more
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