CXCR7 Targeting and Its Major Disease Relevance [PDF]
Frontiers in Pharmacology, 2018 Chemokine receptors are the target of small peptide chemokines. They play various important roles in physiological and pathological processes. CXCR7, later renamed ACKR3, is a non-classical seven transmembrane-spanning receptor whose function as a ...
Chuan Wang +2 more
exaly +6 more sources
CXCR7 impact on CXCL12 biology and disease
Trends in Molecular Medicine, 2013 It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial. CXCR7 expression seems to be enhanced during pathological inflammation and tumor development, and emerging data suggest this receptor is an attractive ...
Lorena Sánchez-Martín +2 more
exaly +5 more sources
CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]
PLoS ONE, 2010 BackgroundCXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses.
Ulrike Naumann +7 more
doaj +7 more sources
Imaging Ligand-Dependent Activation of CXCR7
Neoplasia: An International Journal for Oncology Research, 2009 Chemokine CXCL12 is proposed to promote multiple steps in growth of primary tumors and progression to metastatic disease in more than 20 different cancers.
Kathryn E. Luker +4 more
doaj +4 more sources
CXCR7-TAGLN2 protein complex regulates invasion and metastasis in papillary thyroid carcinoma: a potential therapeutic target [PDF]
Frontiers in ImmunologyObjectiveTo investigate the expression and clinical significance of CXCR7 and TAGLN2 in papillary thyroid carcinoma (PTC), and to explore the molecular mechanisms underlying the interaction between CXCR7 and TAGLN2 in regulating PTC invasion and ...
Chao Zeng +7 more
doaj +2 more sources
Ubiquitination of CXCR7 controls receptor trafficking. [PDF]
PLoS ONE, 2012 The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively.
Meritxell Canals +5 more
doaj +5 more sources
CXCR7 promoted proliferation, migration and invasion in HCC Cells by inactivating Hippo-YAP signaling [PDF]
Discover OncologyBackground CXCR7 (ACKR3) has been well-supported as a promoter of growth and metastasis in hepatocellular carcinoma (HCC). Both CXCR7 and Hippo signaling play roles in organ development.
Genwang Wang +4 more
doaj +2 more sources
Activation of CXCR7 exerts an inhibitory effect on adipogenesis through regulation of β-arrestin2/Wnt and AKT signalling [PDF]
AdipocyteCXCR7, an alternative receptor for the inflammatory chemokine SDF-1, is involved in cell proliferation and migration. Recent studies have reported that CXCR7 also plays a role in adipose tissue.
Shiyue Sun +6 more
doaj +2 more sources
The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma. [PDF]
J Cell Mol MedABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Caniceiro AB +4 more
europepmc +2 more sources
Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excess [PDF]
Scientific ReportsCardiorenal fibrosis is a common feature of chronic cardiovascular disease and recent data suggests that cytokines and chemokines may also drive fibrosis.
Bing H. Wang +6 more
doaj +2 more sources