CXCR7 Targeting and Its Major Disease Relevance [PDF]
Frontiers in Pharmacology, 2018 Chemokine receptors are the target of small peptide chemokines. They play various important roles in physiological and pathological processes. CXCR7, later renamed ACKR3, is a non-classical seven transmembrane-spanning receptor whose function as a ...
Weilin Chen +2 more
exaly +7 more sources
CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor
Scientific Reports, 2021 Most seven transmembrane receptors (7TMRs) are G protein-coupled receptors; however, some 7TMRs evoke intracellular signals through β-arrestin as a biased receptor.
Masato Ishizuka +20 more
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CXCR7-TAGLN2 protein complex regulates invasion and metastasis in papillary thyroid carcinoma: a potential therapeutic target [PDF]
Frontiers in ImmunologyObjectiveTo investigate the expression and clinical significance of CXCR7 and TAGLN2 in papillary thyroid carcinoma (PTC), and to explore the molecular mechanisms underlying the interaction between CXCR7 and TAGLN2 in regulating PTC invasion and ...
Chao Zeng +7 more
doaj +2 more sources
CXCR7 promoted proliferation, migration and invasion in HCC Cells by inactivating Hippo-YAP signaling [PDF]
Discover OncologyBackground CXCR7 (ACKR3) has been well-supported as a promoter of growth and metastasis in hepatocellular carcinoma (HCC). Both CXCR7 and Hippo signaling play roles in organ development.
Genwang Wang +4 more
doaj +2 more sources
Activation of CXCR7 exerts an inhibitory effect on adipogenesis through regulation of β-arrestin2/Wnt and AKT signalling [PDF]
AdipocyteCXCR7, an alternative receptor for the inflammatory chemokine SDF-1, is involved in cell proliferation and migration. Recent studies have reported that CXCR7 also plays a role in adipose tissue.
Shiyue Sun +6 more
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Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excess [PDF]
Scientific ReportsCardiorenal fibrosis is a common feature of chronic cardiovascular disease and recent data suggests that cytokines and chemokines may also drive fibrosis.
Bing H. Wang +6 more
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Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases. [PDF]
Compr PhysiolCentral role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Agarwal S, Bankar A, de Jesus Perez VA.
europepmc +2 more sources
CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa
Open Life Sciences, 2023 CXCR4 and CXCR7 have been revealed to be receptors of CXCL12. This research was designed to probe the expression of chemokine CXCL12 and its receptors CXCR4 and CXCR7 in placental tissues of patients with placenta previa and the effect of CXCL12/CXCR4 ...
Wu Xia, Wang Ying, Li Min
doaj +1 more source
Stem Cell Research & Therapy, 2021 Background Endothelial progenitor cell (EPC) dysfunction contributes to vascular disease in diabetes mellitus. However, the molecular mechanism underlying EPC dysfunction and its contribution to delayed reendothelialization in diabetes mellitus remain ...
Chunyu Jiang +8 more
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Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells. [PDF]
PLoS ONE, 2013 Glioblastoma (GBM) is the most common primary brain tumor in adults. The poor prognosis and minimally successful treatments of these tumors indicates a need to identify new therapeutic targets. Therapy resistance of GBMs is attributed to heterogeneity of
Che Liu +6 more
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