Results 1 to 10 of about 10,649 (214)
CXCR7 Targeting and Its Major Disease Relevance [PDF]
Frontiers in Pharmacology, 2018 Chemokine receptors are the target of small peptide chemokines. They play various important roles in physiological and pathological processes. CXCR7, later renamed ACKR3, is a non-classical seven transmembrane-spanning receptor whose function as a signaling or non-signaling scavenger/decoy receptor is currently under debate.
Chuan Wang, Jianzhong Shen
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The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma. [PDF]
J Cell Mol MedABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Caniceiro AB +4 more
europepmc +2 more sources
Advances in CXCR7 Modulators [PDF]
Pharmaceuticals, 2020 CXC chemokine receptor 7 (CXCR7) is a G-protein-coupled receptor that signals through the β-arrestin pathway. Its ligands include interferon-inducible T cell α chemoattractant (CXCL11) and stromal cell-derived factor-1 (CXCL12). It interacts with CXCR4, and the two are associated with various cancers, as well as other disease states such as coronary ...
Nicole Lounsbury
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CXCR7 impact on CXCL12 biology and disease
Trends in Molecular Medicine, 2013 It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial. CXCR7 expression seems to be enhanced during pathological inflammation and tumor development, and emerging data suggest this receptor is an attractive ...
Lorena Sánchez-Martín +2 more
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CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression [PDF]
Cancer and Metastasis Reviews, 2010 Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 (also called stromal-derived factor-1) is an important α-chemokine that binds primarily to its cognate receptor CXCR4 and thus regulates the ...
Xueqing Sun +2 more
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Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation. [PDF]
Mediators InflammAutoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body’s own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and immune factors all play a part.
Farahani H +4 more
europepmc +2 more sources
CXCR7 activation overrides lung fibrosis [PDF]
Nature Reviews Drug Discovery, 2016 Megan Cully
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CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis [PDF]
Frontiers in Pharmacology, 2021 Loss of control in the trafficking of immune cells to the inflamed lung tissue contributes to the pathogenesis of life-threatening acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS). Targeting CXCR7 has been proposed as a potential therapeutic approach to reduce pulmonary inflammation; however, its role and its
Laetitia Pouzol +6 more
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CXCR7 expression in esophageal cancer [PDF]
Journal of Translational Medicine, 2013 The chemokine CXCL12 and its receptor CXCR4 play a major role in tumor invasion, proliferation and metastasis in different malignant diseases, including esophageal carcinoma, amongst others. CXCR7 was recently identified as a novel alternate receptor for CXCL12.
Tachezy, Michael +6 more
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Endothelial CXCR7 regulates breast cancer metastasis [PDF]
Oncogene, 2015 Atypical chemokine receptor CXCR7 (ACKR3) functions as a scavenger receptor for chemokine CXCL12, a molecule that promotes multiple steps in tumor growth and metastasis in breast cancer and multiple other malignancies. Although normal vascular endothelium expresses low levels of CXCR7, marked upregulation of CXCR7 occurs in tumor vasculature in breast ...
Stacer, Amanda C. +8 more
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