Results 1 to 10 of about 49,192 (255)
The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer [PDF]
Frontiers in Pharmacology, 2020 Chemokines are a family of small, secreted cytokines which regulate a variety of cell functions. The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interaction of
Yi Shi, David J. Riese, Jianzhong Shen
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Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain [PDF]
Molecular Pain, 2016 Background Chemokine axis chemokine C-X-C motif ligand 12/C-X-C chemokine receptor type 4 (CXCL12/CXCR4) is an emerging pain modulator, but mechanisms for its involvement in neuropathic pain remain unclear.
Xin Luo PhD +6 more
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CXCL12 and CXCL13 as potential biomarkers for disease severity and recurrence in respiratory syncytial virus bronchiolitis [PDF]
Scientific ReportsTo examine chemokine expression in children with Respiratory Syncytial Virus (RSV) bronchiolitis and evaluate its clinical utility for early warning and prognosis. Five hospitalised RSV bronchiolitis children and five matched controls were studied.
Lin Zhang +13 more
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The Role of CXCL12 in Kidney Diseases: A Friend or Foe?
Kidney Diseases, 2021 Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines.
Anni Song +3 more
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Polish Journal of Pathology, 2021 It is well known that interactions in the tumour microenvironment are very important in the progression of tumours. We investigated the relationship between chemokine ligand type 12 (CXCL12), chemokine receptor type 4 (CXCR4) and survival in advanced ...
Mehmet Zengin +4 more
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A new obligate CXCL4–CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms
Scientific Reports, 2022 Chemokines form a family of proteins with critical roles in many biological processes in health and disease conditions, including cardiovascular, autoimmune diseases, infections, and cancer.
Khanh T.P. Nguyen +3 more
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Biochemistry and Biophysics Reports, 2021 Chemotactic factors locally secreted from tissues regulate leukocyte migration via cell membrane receptors that induce intracellular signals. It has been suggested that neutrophils stimulated by bacterial peptides secrete a secondary stimulant that ...
Kaoru Kurowarabe +3 more
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Nature Communications, 2023 Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors.
Taichi Nakatani +5 more
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Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12 [PDF]
, 2012 Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within tissues, ultimately resulting in chemoresistance and relapse: disruption of these signaling ...
A Hochhaus +38 more
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A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding
iScience, 2021 Summary: Secreted chemokines are critical mediators of cellular communication that elicit intracellular signaling by binding membrane-bound receptors. Here we demonstrate the development and use of a sensitive real-time approach to quantify secretion and
Carl W. White +3 more
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