Results 1 to 10 of about 31,885 (118)
The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer
Frontiers in Pharmacology, 2020 Chemokines are a family of small, secreted cytokines which regulate a variety of cell functions. The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interaction of
Jianzhong Shen, David Riese
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The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
Frontiers in Physiology, 2014 The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon injury or stress. Although the CXCL12/
Christian Weber +2 more
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The Role of CXCL12 in Kidney Diseases: A Friend or Foe?
Kidney Diseases, 2021 Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines.
Anni Song +3 more
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Polish Journal of Pathology, 2021 It is well known that interactions in the tumour microenvironment are very important in the progression of tumours. We investigated the relationship between chemokine ligand type 12 (CXCL12), chemokine receptor type 4 (CXCR4) and survival in advanced ...
Mehmet Zengin +4 more
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A new obligate CXCL4–CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms
Scientific Reports, 2022 Chemokines form a family of proteins with critical roles in many biological processes in health and disease conditions, including cardiovascular, autoimmune diseases, infections, and cancer.
Khanh T.P. Nguyen +3 more
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Biochemistry and Biophysics Reports, 2021 Chemotactic factors locally secreted from tissues regulate leukocyte migration via cell membrane receptors that induce intracellular signals. It has been suggested that neutrophils stimulated by bacterial peptides secrete a secondary stimulant that ...
Kaoru Kurowarabe +3 more
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Nature Communications, 2023 Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors.
Taichi Nakatani +5 more
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A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding
iScience, 2021 Summary: Secreted chemokines are critical mediators of cellular communication that elicit intracellular signaling by binding membrane-bound receptors. Here we demonstrate the development and use of a sensitive real-time approach to quantify secretion and
Carl W. White +3 more
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Bioluminescent CXCL12 fusion protein for cellular studies of CXCR4 and CXCR7
BioTechniques, 2009 Chemokine CXCL12 and its two known receptors, CXCR4 and CXCR7, may play a role in diseases including tumor growth and metastasis, atherosclerosis, and HIV infection. Therefore, these molecules may be promising targets for drug development.
Kathryn E. Luker +2 more
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CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice
Scientific Reports, 2021 Successful pregnancy inevitably depends on the implantation of a competent embryo into a receptive endometrium. Although many substances have been suggested to improve the rate of embryo implantation targeting enhancement of endometrial receptivity ...
Hwa Seon Koo +11 more
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