Results 41 to 50 of about 33,556 (238)

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration [PDF]

, 2009
FLT3-ITD-mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD-mediated transformation, we performed bone marrow reconstitution assays.
Spoo, A, Bullock, AN, Spoo, Anke Cornelia, Duyster, Justus, Pogacic, Vanda, Dechow, Tobias, Andrea Biondi, Grundler, R, Sabine Ehret, Spoo, Anke, Vanda Pogacic, Anke Spoo, Bullock, Alex N., Villa, A, Pogacic, V, Ehret, S, Georgina Berridge, Knapp, S, Dechow, T, Berridge, G, Tobias Dechow, Juerg Schwaller, Christine Dierks, Grundler, Rebekka, Schwaller, J, Duyster, J, Laurent Brault, Bullock, Alexander, Woetzel, S, Antonello Villa, Dierks, Christine, Brault, Laurent, Stefan Knapp, Justus Duyster, Villa, Antonello, Gasser, C, Gasser, Christelle, Rebekka Grundler, Biondi, A, Sabine Woetzel, Brault, L, Woetzel, Sabine, Knapp, Stefan, Schwaller, Juerg, Biondi, Andrea, Dierks, C, Alex N. Bullock, Christelle Gasser, Ehret, Sabine, Wötzel, Sabine, Berridge, Georgina   +50 more
core   +1 more source

SDF-1/CXCL12: A Chemokine in the Life Cycle of HIV [PDF]

Frontiers in Immunology, 2015
Since 1986, the beginning of our involvement in HIV research, our major interest was focused on the regulation of HIV-1 replication by the transcriptional host cell machinery. Thus, we successively investigated the consequences of inflammatory and specific responses in HIV replication in primary monocytes and memory CD4 + T cells, and explored with ...
openaire   +3 more sources

The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma

Cancer Biology & Medicine, 2021
Esophageal cancer is the eighth most common malignant tumor and the sixth leading cause of cancer-related death worldwide. Esophageal squamous cell carcinoma (ESCC) is the main histological type of esophageal cancer, and accounts for 90% of all cancer ...
Xianxian Wu, Hongdian Zhang, Zhilin Sui, Yang Wang, Zhentao Yu   +4 more
doaj   +1 more source

CXCL12-PLGA/Pluronic Nanoparticle Internalization Abrogates CXCR4-Mediated Cell Migration

Nanomaterials, 2020
Chemokine-induced chemotaxis mediates physiological and pathological immune cell trafficking, as well as several processes involving cell migration. Among them, the role of CXCL12/CXCR4 signaling in cancer and metastasis is well known, and CXCR4 has been
Anissa Pisani, Roberto Donno, Arianna Gennari, Giulia Cibecchini, Federico Catalano, Roberto Marotta, Pier Paolo Pompa, Nicola Tirelli, Giuseppe Bardi   +8 more
doaj   +1 more source

The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with chemokine CXCL12 [PDF]

, 2023
Chemokines engage in heterodimeric interactions to activate or dampen their cognate receptors in inflammatory conditions. The chemokine CXCL12 forms with the alarmin HMGB1 a patho-physiologically relevant heterocomplex (HMGB1●CXCL12), whose formation ...
Francesco De Marchis, Tim Schulte, Marco Bianchi, Stefano Ricagno, Chiara Zucchelli, Liam Colley, Massimo Crippa, Giacomo Quilici, Malisa Vittoria Mantonico, Gabriele Giachin, Federica De Leo, Giovanna Musco, Michela Ghitti   +12 more
core   +1 more source

MIF and CXCL12 in cardiovascular diseases: functional differences and similarities

Frontiers in Immunology, 2015
Coronary artery disease (CAD) as part of the cardiovascular diseases is a pathology caused by atherosclerosis, a chronic inflammatory disease of the vessel wall characterized by a massive invasion of lipids and inflammatory cells into the inner vessel ...
Emiel eVan Der Vorst, Yvonne eDoering, Christian eWeber   +2 more
doaj   +1 more source

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4. [PDF]

, 2017
International audienceThe chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expressed in blood and tissue cells, and is essential during embryogenesis and hematopoiesis.
Caucheteux, Stephan, Michelle L. McCully, Mccully, Michelle L, Mario Mellado, Vladimir Purvanov, Marcus Thelen, Bernhard Moser, Collins, Paul J., Daniel F. Legler, Moser, Bernhard, Valentina Cecchinato, Yoan R. Monneau, Uguccioni, Mariagrazia, Legler, Daniel F., Collins, Paul J, Paul J. Collins, Monneau, Yoan R., Laura Martínez‐Muñoz, Vincent Piguet, Mellado, Mario, Laufer, Julia M., Cecchinato, Valentina, Piguet, Vincent, Stephan Caucheteux, Lortat-Jacob, Hugues, Thelen, Sylvia, Martínez-Muñoz, Laura, Sylvia Thelen, Mariagrazia Uguccioni, Hugues Lortat‐Jacob, Wheeldon, James, Legler, Daniel F, James Wheeldon, Purvanov, Vladimir, McCully, Michelle L., Laufer, Julia M, Santiago, César, Thelen, Marcus, Collins, Paul, César Santiago, Monneau, Yoan, Julia M. Laufer   +41 more
core   +2 more sources

Diversity and inter-connections in the CXCR4 chemokine receptor/ligand family: molecular perspectives

Frontiers in Immunology, 2015
CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow and their recruitment to sites of injury, as well as affect processes such as cell arrest, survival and angiogenesis.
Lukas ePawig, Christina eKlasen, Christian eWeber, Jürgen eBernhagen, Heidi eNoels   +4 more
doaj   +1 more source

Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling

BMC Pregnancy and Childbirth, 2020
Background CXCL12(chemokine ligand 12, CXCL12) and its receptors CXCR4 are widely expressed in maternal-fetal interface and plays an adjust role in materno-fetal dialogue and immune tolerance during early pregnancy.
Jiayi Zheng, Danni Qu, Chen Wang, Ling Ding, Wenhui Zhou   +4 more
doaj   +1 more source

STUDY OF CXCL12, CCR4, EGFR GENE EXPRESSION IN MIGRATING MYELOMONOBLASTIC LEUKEMIA CELLS BEFORE AND AFTER CHEMOTHERAPY

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Аim. A study of CXCL12 effect on the migration of mononuclear cells isolated from healthy patients, from patients with myelomonoblastic leukemia before and after chemotherapy and the study of CCR4, EGFR and CXCL12 genes expression after exposure to ...
A. B. Filina, O. A. Svitich, Yu. I. Ammur, A. K. Golenkov, E. F. Klinushkina, V. V. Zverev   +5 more
doaj   +1 more source