Results 51 to 60 of about 33,556 (238)
Essential role of immobilized chemokine CXCL12 in the regulation of the humoral immune response. [PDF]
Proc Natl Acad Sci U S A, 2017 International audienceChemokines control the migration of a large array of cells by binding to specific receptors on cell surfaces. The biological function of chemokines also depends on interactions between nonreceptor binding domains and proteoglycans ...
Barinov A +6 more
europepmc +2 more sources
Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery [PDF]
Current Pharmacology Reports, 2016 This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies.
Yan, Wang, Ying, Xie, David, Oupický
openaire +2 more sources
Journal of Lipid Research, 2019 CXC chemokine ligand 12 (CXCL12) is a member of the CXC chemokine family and mainly acts on cell chemotaxis. CXCL12 also elicits a proatherogenic role, but the molecular mechanisms have not been fully defined yet.
Jia-Hui Gao +10 more
doaj +1 more source
Cancer Cell International, 2007 Purpose The CXCR4/CXCL12 chemokine axis may play a critical role in guiding CXCR4+ circulating malignant cells to organ specific locations that actively secrete its ligand CXCL12 (SDF-1) such as bone, brain, liver, and lungs.
Antecka Emilia +6 more
doaj +1 more source
Frontiers in Neuroscience, 2023 BackgroundC-X-C motif chemokine 12 (CXCL12) is a chemokine that performs many functions. Studies have shown that CXCL12 can aggravate inflammatory symptoms in the central nervous system (CNS). Evidence also indicates that CXCL12 can promote the repair of
Dahe Lin +13 more
doaj +1 more source
, 2012 The recruitment of T lymphocytes during diseases such as rheumatoid arthritis is regulated by stimulation of the chemokine receptors expressed by these cells.
O'Boyle, Graeme +10 more
core +1 more source
The structural and physicochemical properties of the chemokine CXCL12.
, 2020 (A) The sequence of CXCL12, its annotated structural domains, and quantification of side chain conformational variability and normalized SASA. The values are given in S2 Table.
Tony Ngo (5072279) +6 more
core +1 more source
Inflammation Controls B Lymphopoiesis by Regulating Chemokine CXCL12 Expression [PDF]
The Journal of Experimental Medicine, 2004 Inflammation removes developing and mature lymphocytes from the bone marrow (BM) and induces the appearance of developing B cells in the spleen. BM granulocyte numbers increase after lymphocyte reductions to support a reactive granulocytosis. Here, we demonstrate that inflammation, acting primarily through tumor necrosis factor α (TNFα), mobilizes BM ...
Ueda, Yoshihiro +4 more
openaire +2 more sources
Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord. [PDF]
PLoS ONE, 2016 Toll-like receptor 4 (TLR4) is important for the pathogenesis of inflammatory reactions and the promotion of pain processing after ischemia/reperfusion (IR) in spinal cord.
Xiao-Qian Li +4 more
doaj +1 more source
Profiling of Cxcl12 receptors, Cxcr4 and Cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for Cxcr7 in controlling Cxcl12 activity. [PDF]
PLoS ONE, 2014 In mice the chemokine Cxcl12 and its receptor Cxcr4 participate in maintenance of the spermatogonial population during postnatal development. More complexity arises since Cxcl12 also binds to the non-classical/atypical chemokine receptor Cxcr7.
Birgit Westernströer +5 more
doaj +1 more source