Evaluation of the Expression Levels of Notch Signaling Pathway-Related Genes; JAG1, CXCR4, and MIB1 in Acute Myeloid Leukemia Patients [PDF]
Middle East Journal of Cancer, 2022 Background: Acute myeloid leukemia (AML) is a complex disease characterized by clonal expansion of undifferentiated myeloid precursors, resulting in impaired hematopoiesis and bone marrow failure.
Seyedeh Hananeh Ghafelehbashi +4 more
doaj +1 more source
Extracellular Hsp70 Is Involved in the CXCL12/CXCR4 Pathway in Primary Human Nasal Epithelial Cells: A Preliminary Study [PDF]
Journal of Rhinology, 2023 Background and Objectives To date, no studies have been conducted on the interaction between extracellular heat shock protein 70 (Hsp70) and C-X-C chemokine receptor type 4 (CXCR4) in the upper airway.
Seong Hee Kim +3 more
doaj +1 more source
Aberrant regulation of CXCR4 in cancer via deviant microRNA-targeted interactions
Epigenetics, 2022 CXCR4 is involved in many facets of cancer, including being a major player in establishing metastasis. This is in part due to the deregulation of CXCR4, which can be attributed to many genetic and epigenetic mechanisms, including aberrant microRNA–CXCR4 ...
Alexei J. Stuckel +3 more
doaj +1 more source
Selective expansion of viral variants following experimental transmission of a reconstituted feline immunodeficiency virus quasispecies [PDF]
, 2013 Following long-term infection with virus derived from the pathogenic GL8 molecular clone of feline immunodeficiency virus (FIV), a range of viral variants emerged with distinct modes of interaction with the viral receptors CD134 and CXCR4, and ...
A de Parseval +58 more
core +22 more sources
Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML [PDF]
, 2014 Pharmacological targeting of BTK using ibrutinib has recently shown encouraging clinical activity in a range of lymphoid malignancies. Recently we reported that ibrutinib inhibits human acute myeloid leukemia (AML) blast proliferation and leukemic cell ...
Bowles, Kristian M +6 more
core +8 more sources
CXCR4: A Potential Chemokine Receptor for Future Regenerative Therapeutic Target [PDF]
Journal of Cell and Molecular Research, 2015 Understanding the molecular mechanisms in regeneration could help the stem cell therapists to improve the clinical practices and could be considered a major milestone in the translation of stem cell research to clinics.
Asieh Heirani-Tabasi +1 more
doaj +1 more source
Indonesian Journal of Cancer, 2022 Background: Infiltrating urothelial carcinoma of the bladder (IUCB) is an aggressive urinary tract cancer. Most of the patients were diagnosed with advanced stages, and many have metastasized.
Siska Dwiyantie Wahyuni +3 more
doaj +1 more source
CXCL12-CXCR4 axis: its role and the drug inhibitors on each type of cancers [PDF]
World Cancer Research Journal, 2022 Objective: Chemokine 12, C-X-C Motif Chemokine Ligand 12 (CXCL12), and its receptor C-X-C Motif Chemokine Ligand 4 (CXCR4), both play essential and critical roles in the development of different types of cancers.
A. Zarinkhat +5 more
doaj +1 more source
The Role of CXCL12 in Kidney Diseases: A Friend or Foe?
Kidney Diseases, 2021 Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines.
Anni Song +3 more
doaj +1 more source
CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa
Open Life Sciences, 2023 CXCR4 and CXCR7 have been revealed to be receptors of CXCL12. This research was designed to probe the expression of chemokine CXCL12 and its receptors CXCR4 and CXCR7 in placental tissues of patients with placenta previa and the effect of CXCL12/CXCR4 ...
Wu Xia, Wang Ying, Li Min
doaj +1 more source