Biochimica Et Biophysica Acta - Biomembranes, 2007 The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome.
Busillo, John M., Benovic, Jeffrey L.
exaly +3 more sources
CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry
Biochemical Pharmacology, 2018 The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co-receptor facilitating HIV entry. Accordingly, CXCR4 is considered as an attractive therapeutic target. Drug side effects and poor pharmacokinetic properties have been major hurdles that have prevented the implementation
Anneleen van Hout +2 more
exaly +4 more sources
Evaluation of the Expression Levels of Notch Signaling Pathway-Related Genes; JAG1, CXCR4, and MIB1 in Acute Myeloid Leukemia Patients [PDF]
Middle East Journal of Cancer, 2022 Background: Acute myeloid leukemia (AML) is a complex disease characterized by clonal expansion of undifferentiated myeloid precursors, resulting in impaired hematopoiesis and bone marrow failure.
Seyedeh Hananeh Ghafelehbashi +4 more
doaj +1 more source
CXCL12-CXCR4 axis: its role and the drug inhibitors on each type of cancers [PDF]
World Cancer Research Journal, 2022 Objective: Chemokine 12, C-X-C Motif Chemokine Ligand 12 (CXCL12), and its receptor C-X-C Motif Chemokine Ligand 4 (CXCR4), both play essential and critical roles in the development of different types of cancers.
A. Zarinkhat +5 more
doaj +1 more source
Check update pattern of tumorigenic vasculature signature based on MMP9 and CXCR4 expression in locally advanced breast cancer [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Locally advanced breast cancers (LABC) are the most common women malignant tumors. Appropriate vasculature is required for tumor growth support, formed by involving protein signaling, including matrix metalloprotein 9 (MMP9) and C-X-C chemokine ...
Mochamad Bachtiar Budianto +3 more
doaj +1 more source
Aberrant regulation of CXCR4 in cancer via deviant microRNA-targeted interactions
Epigenetics, 2022 CXCR4 is involved in many facets of cancer, including being a major player in establishing metastasis. This is in part due to the deregulation of CXCR4, which can be attributed to many genetic and epigenetic mechanisms, including aberrant microRNA–CXCR4 ...
Alexei J. Stuckel +3 more
doaj +1 more source
Melittin Prevents Metastasis of Epidermal Growth Factor-Induced MDA-MB-231 Cells through The Inhibition of The SDF-1α/CXCR4 Signaling Pathway [PDF]
Cell Journal, 2022 Objective: Melittin is one of the natural components of bee venom (Apis mellifera), and its anticancer and antimetastatic properties have been well established, but the underlying mechanism remains elusive.
Fatemeh Salimian +2 more
doaj +1 more source
CXCR4: A Potential Chemokine Receptor for Future Regenerative Therapeutic Target [PDF]
Journal of Cell and Molecular Research, 2015 Understanding the molecular mechanisms in regeneration could help the stem cell therapists to improve the clinical practices and could be considered a major milestone in the translation of stem cell research to clinics.
Asieh Heirani-Tabasi +1 more
doaj +1 more source
Indonesian Journal of Cancer, 2022 Background: Infiltrating urothelial carcinoma of the bladder (IUCB) is an aggressive urinary tract cancer. Most of the patients were diagnosed with advanced stages, and many have metastasized.
Siska Dwiyantie Wahyuni +3 more
doaj +1 more source
[68Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2023 [68Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years.
Hessamoddin Roustaei +5 more
doaj +1 more source