Results 11 to 20 of about 88,749 (308)
CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry [PDF]
Biochemical Pharmacology, 2018 The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co-receptor facilitating HIV entry. Accordingly, CXCR4 is considered as an attractive therapeutic target. Drug side effects and poor pharmacokinetic properties have been major hurdles that have prevented the implementation
Anneleen van Hout +2 more
exaly +5 more sources
Biochimica Et Biophysica Acta - Biomembranes, 2007 The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome.
Busillo, John M., Benovic, Jeffrey L.
exaly +3 more sources
International Journal of General MedicineDanChan Huang,1 DanXia Lin,2 SiXian Liang,2 Jing Lin1 1Department of Oncology, The First Affiliated Hospital of Shantou University Medical College, Shantou City, Guangdong Province, 515000, People’s Republic of China; 2Department of Breast Oncology ...
Huang D, Lin D, Liang S, Lin J
doaj +2 more sources
Evaluation of the Expression Levels of Notch Signaling Pathway-Related Genes; JAG1, CXCR4, and MIB1 in Acute Myeloid Leukemia Patients [PDF]
Middle East Journal of Cancer, 2022 Background: Acute myeloid leukemia (AML) is a complex disease characterized by clonal expansion of undifferentiated myeloid precursors, resulting in impaired hematopoiesis and bone marrow failure.
Seyedeh Hananeh Ghafelehbashi +4 more
doaj +1 more source
Extracellular Hsp70 Is Involved in the CXCL12/CXCR4 Pathway in Primary Human Nasal Epithelial Cells: A Preliminary Study [PDF]
Journal of Rhinology, 2023 Background and Objectives To date, no studies have been conducted on the interaction between extracellular heat shock protein 70 (Hsp70) and C-X-C chemokine receptor type 4 (CXCR4) in the upper airway.
Seong Hee Kim +3 more
doaj +1 more source
Aberrant regulation of CXCR4 in cancer via deviant microRNA-targeted interactions
Epigenetics, 2022 CXCR4 is involved in many facets of cancer, including being a major player in establishing metastasis. This is in part due to the deregulation of CXCR4, which can be attributed to many genetic and epigenetic mechanisms, including aberrant microRNA–CXCR4 ...
Alexei J. Stuckel +3 more
doaj +1 more source
CXCR4: A Potential Chemokine Receptor for Future Regenerative Therapeutic Target [PDF]
Journal of Cell and Molecular Research, 2015 Understanding the molecular mechanisms in regeneration could help the stem cell therapists to improve the clinical practices and could be considered a major milestone in the translation of stem cell research to clinics.
Asieh Heirani-Tabasi +1 more
doaj +1 more source
Indonesian Journal of Cancer, 2022 Background: Infiltrating urothelial carcinoma of the bladder (IUCB) is an aggressive urinary tract cancer. Most of the patients were diagnosed with advanced stages, and many have metastasized.
Siska Dwiyantie Wahyuni +3 more
doaj +1 more source
CXCL12-CXCR4 axis: its role and the drug inhibitors on each type of cancers [PDF]
World Cancer Research Journal, 2022 Objective: Chemokine 12, C-X-C Motif Chemokine Ligand 12 (CXCL12), and its receptor C-X-C Motif Chemokine Ligand 4 (CXCR4), both play essential and critical roles in the development of different types of cancers.
A. Zarinkhat +5 more
doaj +1 more source
Small Molecule Inhibitors of CXCR4 [PDF]
Theranostics, 2013 CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated with several diseases, such as HIV, cancer, WHIM syndrome, rheumatoid arthritis, pulmonary fibrosis and lupus.
Debnath B +4 more
openaire +2 more sources