Results 21 to 30 of about 88,749 (308)
The Role of CXCL12 in Kidney Diseases: A Friend or Foe?
Kidney Diseases, 2021 Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells. The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines.
Anni Song +3 more
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Targeting of CXCR4 by the Naturally Occurring CXCR4 Antagonist EPI-X4 in Waldenström’s Macroglobulinemia [PDF]
Cancers, 2020 CXCR4 expression and downstream signaling have been identified as key factors in malignant hematopoiesis. Thus, up to 40% of all patients with Waldenström’s macroglobulinemia (WM) carry an activating mutation of CXCR4 that leads to a more aggressive clinical course and inferior outcome upon treatment with the Bruton’s tyrosine kinase inhibitor ...
Lisa Marie Kaiser +9 more
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CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa
Open Life Sciences, 2023 CXCR4 and CXCR7 have been revealed to be receptors of CXCL12. This research was designed to probe the expression of chemokine CXCL12 and its receptors CXCR4 and CXCR7 in placental tissues of patients with placenta previa and the effect of CXCL12/CXCR4 ...
Wu Xia, Wang Ying, Li Min
doaj +1 more source
CXCR4 Ligands: The Next Big Hit? [PDF]
Journal of Nuclear Medicine, 2017 The G protein-coupled protein receptor C-X-C chemokine receptor 4 (CXCR4) is an attractive target for cancer diagnosis and treatment, as it is overexpressed in many solid and hematologic cancers. Binding of its ligand, C-X-C chemokine ligand 12 (CXCL12), results in receptor internalization and activation of several signal transduction pathways, such as
Walenkamp, Annemiek M.E. +3 more
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Check update pattern of tumorigenic vasculature signature based on MMP9 and CXCR4 expression in locally advanced breast cancer [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Locally advanced breast cancers (LABC) are the most common women malignant tumors. Appropriate vasculature is required for tumor growth support, formed by involving protein signaling, including matrix metalloprotein 9 (MMP9) and C-X-C chemokine ...
Mochamad Bachtiar Budianto +3 more
doaj +1 more source
Targeting CXCR4 in AML and ALL [PDF]
Frontiers in Oncology, 2020 The interaction of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) blasts with the bone marrow microenvironment regulates self-renewal, growth signaling, as well as chemotherapy resistance. The chemokine receptor, CXC receptor 4 (CXCR4), with its ligand chemokine ligand 12 (CXCL12), plays a key role in the survival and migration of ...
Cancilla, Daniel +2 more
openaire +4 more sources
Indonesian Journal of Cancer, 2021 Background: Papillary thyroid carcinoma (PTC) that has metastasized has a higher risk because of the poor prognosis, ranging from decreased quality of life of the patient to death. There is a need for markers that can understand the image of the tumor so
Nurdhani Hi Djafar +2 more
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Melittin Prevents Metastasis of Epidermal Growth Factor-Induced MDA-MB-231 Cells through The Inhibition of The SDF-1α/CXCR4 Signaling Pathway [PDF]
Cell Journal, 2022 Objective: Melittin is one of the natural components of bee venom (Apis mellifera), and its anticancer and antimetastatic properties have been well established, but the underlying mechanism remains elusive.
Fatemeh Salimian +2 more
doaj +1 more source
Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration [PDF]
Cancer Biology & Therapy, 2013 The stromal cell-derived factor-1α SDF-1α (CXCL12)/CXCR4 axis has been linked to poor prognosis in some cancers. As histone deacetylase inhibitors (HDIs) exert antitumor effects by targeting proteins affecting cell migration, we sought to evaluate the effects of the HDIs apicidin, vorinostat, entinostat (MS-275) and romidepsin on the expression and ...
Caterina, Ierano +7 more
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Expression of CXCR4 on feline peripheral blood mononuclear cells: effect of feline immunodeficiency virus infection. [PDF]
, 2003 CXCR4 expression on feline peripheral blood mononuclear cells (PBMC) was analyzed. While monocytes and B lymphocytes expressed CXCR4, no CXCR4 was detected on T lymphocytes, in stark contrast to the expression pattern on T lymphocytes from humans.
Hosie, M.J., Willett, B.J., Cannon, C.A.
core +1 more source