Results 21 to 30 of about 94,110 (297)

AMD3100/CXCR4 Inhibitor [PDF]

Frontiers in Immunology, 2015
The original bicyclam, JM1657 (JM standing for Johnson Matthey) was discovered as a contaminant in a commercial preparation of monocyclams when evaluated for their anti-HIV activity. The original compound, in which the cyclam rings were tethered by a C–C linkage could not be re-synthesized but launched the synthesis of new bicyclams in which the cyclam
openaire   +4 more sources

Hyperviscosity Syndrome Induced Bilateral Visual and Auditory Impairment in Therapy Resistant Waldenström Macroglobulinemia with MYD88 and CXCR4 Mutations

Journal of Blood Medicine, 2023
Marie M Plante,1 ErinMarie O Kimbrough,2 Amit K Agarwal,3 Liuyan Jiang,4 Kirk Bourgeois,4 Greta C Stamper,5 Michael W Stewart,6 Han W Tun2 1Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA; 2Division of Hematology and Oncology, Mayo ...
Plante MM, Kimbrough EO, Agarwal AK, Jiang L, Bourgeois K, Stamper GC, Stewart MW, Tun HW   +7 more
doaj  

CXCL12 and CXCR4 as Potential Early Biomarkers for Luminal A and Luminal B Subtypes of Breast Cancer

Cancer Management and Research, 2023
Joanna Motyka,1 Ewa Gacuta,2 Aleksandra Kicman,3 Monika Kulesza,1 Paweł Malinowski,4 Sławomir Ławicki1 1Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland ...
Motyka J, Gacuta E, Kicman A, Kulesza M, Malinowski P, Ławicki S   +5 more
doaj  

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor [PDF]

, 2013
Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation.
Dembowsky, K., Dembowsky, Klaus, Romagnoli, B., G Spohn, Karpova, Darja, Patel, K., Chevalier, E., Levesque, J. P., E Chevalier, D Karpova, Patel, Kalpana, Spohn, Gabriele, Romagnoli, Barbara, Schulz, M., Wiercinska, Eliza, Chevalier, Eric, H Bonig, K Dauber, E Wiercinska, J P Levesque, Schulz, Miriam, Chudziak, D., K Dembowsky, Dauber, Katrin, Karpova, D., B Romagnoli, A R Pettit, Wiercinska, E., D Chudziak, Levesque, Jean-Pierre, Bönig, Halvard-Björn, Spohn, G., Pettit, Allison R., M Schulz, K Patel, Bonig, H., Pettit, A. R., Chudziak, Doreen, Dauber, K.   +38 more
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WHIM Syndrome: A Literature Review and a Report of Two Cases in One Family

Клиническая онкогематология, 2023
WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis) is a rare genetic disease associated with activating germline mutations in the gene encoding chemokine receptor CXCR4.
Mariya Viktorovna Marchenko, Yu. N. Kuznetsov, A. V. Lapina, I. A. Mikhailova, T. A. Bykova, T. S. Shchegoleva, V. V. Baikov, A. D. Kulagin   +7 more
doaj   +1 more source

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration [PDF]

, 2009
FLT3-ITD-mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD-mediated transformation, we performed bone marrow reconstitution assays.
Spoo, A, Bullock, AN, Spoo, Anke Cornelia, Duyster, Justus, Pogacic, Vanda, Dechow, Tobias, Andrea Biondi, Grundler, R, Sabine Ehret, Spoo, Anke, Vanda Pogacic, Anke Spoo, Bullock, Alex N., Villa, A, Pogacic, V, Ehret, S, Georgina Berridge, Knapp, S, Dechow, T, Berridge, G, Tobias Dechow, Juerg Schwaller, Christine Dierks, Grundler, Rebekka, Schwaller, J, Duyster, J, Laurent Brault, Bullock, Alexander, Woetzel, S, Antonello Villa, Dierks, Christine, Brault, Laurent, Stefan Knapp, Justus Duyster, Villa, Antonello, Gasser, C, Gasser, Christelle, Rebekka Grundler, Biondi, A, Sabine Woetzel, Brault, L, Woetzel, Sabine, Knapp, Stefan, Schwaller, Juerg, Biondi, Andrea, Dierks, C, Alex N. Bullock, Christelle Gasser, Ehret, Sabine, Wötzel, Sabine, Berridge, Georgina   +50 more
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Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

4 open, 2019
A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

The biology of CCR5 and CXCR4 [PDF]

Current Opinion in HIV and AIDS, 2009
We discuss the current knowledge concerning the biology of CXCR4 and CCR5 and their roles in HIV-1 infection.Important research findings reported in the last 2 years have advanced our knowledge in the field of HIV coreceptors and pathogenesis. Novel methods have been used to crystallize two new members of the G-protein coupled receptors.
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Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus [PDF]

, 2002
Feline CXCR4 and CCR5 were expressed in feline cells as fusion proteins with enhanced green fluorescent protein (EGFP). Expression of the EGFP fusion proteins was localized to the cell membrane, and surface expression of CXCR4 was confirmed by using a ...
Hosie, M.J., Willett, B.J., Cannon, C.A.
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Factores inmunogenéticos relacionados con la resistencia/susceptibilidad a la infección por el VIH-1 y su progresión hacia SIDA [PDF]

, 2006
[spa] Los individuos expuestos al VIH-1 y no infectados y los pacientes infectados no progresores de larga duración son situaciones modelo para estudiar factores del huésped implicados en conferir resistencia a la infección / progresión y su conocimiento
Soriano Viladomiu, Alex
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