Results 1 to 10 of about 22,166,132 (318)

Atlas of the HIV-1 Reservoir in Peripheral CD4 T Cells of Individuals on Successful Antiretroviral Therapy

mBio, 2021
Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Cristina Gálvez, Judith Grau-Expósito, Victor Urrea, Bonaventura Clotet, Vicenç Falcó, Maria José Buzón, Javier Martinez-Picado   +6 more
doaj   +1 more source

HIV-1: To Splice or Not to Splice, That Is the Question

Viruses, 2021
The transcription of the HIV-1 provirus results in only one type of transcript—full length genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the genomic RNA must completely splice.
Ann Emery, Ronald Swanstrom
doaj   +1 more source

Implementation of point-of-care testing and prevalence of cryptococcal antigenaemia among patients with advanced HIV disease in Mumbai, India

BMJ Open, 2023
Objectives To describe the implementation of screening for cryptococcal antigenaemia by point-of-care (POC) serum cryptococcal antigen (CrAg) lateral flow assay, measure the prevalence and factors associated with serum cryptococcal antigenaemia in the ...
Amit Harshana, Raman Mahajan, Reshu Agarwal, Shrikala Acharya, Amol Palkar, Ramesh Reddy Allam, Vijay Kumar Karanjkar, Dhirubhai Rathod, Prashant Deshpande, Shashikant Todmal, Sagar Koli, Sachin Dhande, Jayesh Dale, Vijay V Yeldandi, Sunita Upadhyaya, Melissa Nyendak   +15 more
doaj   +1 more source

Weak SARS-CoV-2-specific responses of TIGIT-expressing CD8+ T cells in people living with HIV after a third dose of a SARS-CoV-2 inactivated vaccine

Chinese Medical Journal, 2023
. Background:. T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains (TIGIT), an inhibitory receptor expressed on T cells, plays a dysfunctional role in antiviral infection and antitumor activity.
Junyan Jin, Xiuwen Wang, Yongzheng Li, Xiaodong Yang, Hu Wang, Xiaoxu Han, Jin Sun, Zhenglai Ma, Junyi Duan, Guanghui Zhang, Tao Huang, Tong Zhang, Hao Wu, Xin Zhang, Bin Su, Yanjie Yin   +15 more
doaj   +1 more source

The RNA surveillance proteins UPF1, UPF2 and SMG6 affect HIV-1 reactivation at a post-transcriptional level

Retrovirology, 2018
Background The ability of human immunodeficiency virus type 1 (HIV-1) to form a stable viral reservoir is the major obstacle to an HIV-1 cure and post-transcriptional events contribute to the maintenance of viral latency.
Shringar Rao, Raquel Amorim, Meijuan Niu, Abdelkrim Temzi, Andrew J. Mouland   +4 more
doaj   +1 more source

HIV-1 Hijacking of Host ATPases and GTPases That Control Protein Trafficking

Frontiers in Cell and Developmental Biology, 2021
The human immunodeficiency virus (HIV-1) modifies the host cell environment to ensure efficient and sustained viral replication. Key to these processes is the capacity of the virus to hijack ATPases, GTPases and the associated proteins that control ...
Lucas A. Tavares, Yunan C. Januário, Luis L. P. daSilva   +2 more
doaj   +1 more source

Targeting the HIV reservoir: chimeric antigen receptor therapy for HIV cure

Chinese Medical Journal, 2023
. Although antiretroviral therapy (ART) can reduce the viral load in the plasma to undetectable levels in human immunodeficiency virus (HIV)-infected individuals, ART alone cannot completely eliminate HIV due to its integration into the host cell genome ...
Shuang Li, Hu Wang, Na Guo, Bin Su, Olivier Lambotte, Tong Zhang, Yanjie Yin   +6 more
doaj   +1 more source

HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex

mBio, 2016
Stress granules (SGs) are dynamic accumulations of stalled preinitiation complexes and translational machinery that assemble under stressful conditions.
Alessandro Cinti, Valerie Le Sage, Marwan Ghanem, Andrew J. Mouland   +3 more
doaj   +1 more source

Dificuldade sexual vivenciada por mulheres em crise de HIV-1 La dificultad sexual vivida por mujeres en crisis de HIV-1 Sexual problems experienced by women in an HIV-1 crisis

Revista Latino-Americana de Enfermagem, 2000
Esta pesquisa de caráter descritivo insere-se nos pressupostos dos métodos qualitativos de investigação, sendo fundamentada pela Teoria da Crise preconizada por CAPLAN (1966).
Mara Rúbia Ignácio de Freitas, Elucir Gir, Antonia Regina Furegatto Rodrigues   +2 more
doaj   +1 more source

HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases

Scientific Reports, 2017
HIV-1 co-opts several host machinery to generate a permissive environment for viral replication and transmission. In this work we reveal how HIV-1 impacts the host translation and intracellular vesicular trafficking machineries for protein synthesis and ...
Alessandro Cinti, Valerie Le Sage, Miroslav P. Milev, Fernando Valiente-Echeverría, Christina Crossie, Marie-Joelle Miron, Nelly Panté, Martin Olivier, Andrew J. Mouland   +8 more
doaj   +1 more source