HIV-1 Prevention for HIV-1 Serodiscordant Couples [PDF]
A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling ...
Curran, K +5 more
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HIV-1 transmission and acute HIV-1 infection [PDF]
An understanding of the central events in the transmission of HIV-1 infection is critical to the development of effective strategies to prevent infection. Although the main routes of transmission have been known for some time, surprisingly little is known about the factors that influence the likelihood of transmitting or acquiring HIV-1 infection. Once
Hansasuta, P, Rowland-Jones, S
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In 1981, the acquired immunodeficiency syndrome (AIDS) appeared insidiously and mystified doctors and scientists alike. No one could have predicted then that it would become, arguably, the worst plague in human history. Today, 33 million persons are living with infection by the human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS ...
Ho, David D., Bieniasz, Paul D.
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Effect of early antiretroviral therapy during primary HIV-1 infection on cell-associated HIV-1 DNA and plasma HIV-1 RNA [PDF]
BACKGROUND: Early initiation of combination antiretroviral therapy (ART) during primary HIV-1 infection may prevent the establishment of large viral reservoirs, possibly resulting in improved control of plasma viraemia rebound after ART cessation ...
Niederoest, B +40 more
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Similar But Different: Integrated Phylogenetic Analysis of Austrian and Swiss HIV-1 Sequences Reveal Differences in Transmission Patterns of the Local HIV-1 Epidemics [PDF]
OBJECTIVES Phylogenetic analyses of two or more countries allow to detect differences in transmission dynamics of local HIV-1 epidemics beyond differences in demographic characteristics.
Klimkait, Thomas; https://orcid.org/ +106 more
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Validation of replicative phenotyping to detect and assign HIV-1 resistance in clinical specimens [PDF]
The ability of HIV-1 to develop resistance to antiretroviral drugs has limited the overall efficacy of combination therapy to suppress viral replication.
Louvel, Séverine
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Frequent intra-subtype recombination among HIV-1 circulating in Tanzania. [PDF]
The study estimated the prevalence of HIV-1 intra-subtype recombinant variants among female bar and hotel workers in Tanzania. While intra-subtype recombination occurs in HIV-1, it is generally underestimated.
Kiwelu, Ireen E +33 more
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PANGEA-HIV/PANGEA-Sequences: v1.0.0 [PDF]
<h2><a href="https://github.com/pangea-hiv/#hiv-consensus-sequence-repository-of-the-pangea-hiv-consortium">HIV Consensus Sequence Repository</a><br><a href="https://github.com/pangea-hiv/#hiv-consensus-sequence-repository-of ...
PANGEA-HIV Consortium
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HIV-1 transmissions during asymptomatic infection : exploring the impact of changes in HIV-1 viral load due to coinfections [PDF]
High HIV-1 plasma viral loads (PVLs) in sub-Saharan Africa, partly because of high rates of coinfection, may have been one of the drivers of the “explosive” epidemics seen in that region.
Baggaley, Rebecca F +3 more
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Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription [PDF]
Abstract Background Transcription of HIV-1 genes is activated by HIV-1 Tat protein, which induces phosphorylation of RNA polymerase II (RNAPII) C-terminal domain (CTD) by CDK9/cyclin T1. Earlier we showed that CDK2/cyclin E phosphorylates HIV-1 Tat in vitro.
Gordeuk Victor R +9 more
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