Similar But Different: Integrated Phylogenetic Analysis of Austrian and Swiss HIV-1 Sequences Reveal Differences in Transmission Patterns of the Local HIV-1 Epidemics [PDF]
OBJECTIVES Phylogenetic analyses of two or more countries allow to detect differences in transmission dynamics of local HIV-1 epidemics beyond differences in demographic characteristics.
Klimkait, Thomas; https://orcid.org/ +106 more
core +1 more source
Validation of replicative phenotyping to detect and assign HIV-1 resistance in clinical specimens [PDF]
The ability of HIV-1 to develop resistance to antiretroviral drugs has limited the overall efficacy of combination therapy to suppress viral replication.
Louvel, Séverine
core +1 more source
HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex
Stress granules (SGs) are dynamic accumulations of stalled preinitiation complexes and translational machinery that assemble under stressful conditions.
Alessandro Cinti +3 more
doaj +1 more source
Esta pesquisa de caráter descritivo insere-se nos pressupostos dos métodos qualitativos de investigação, sendo fundamentada pela Teoria da Crise preconizada por CAPLAN (1966).
Mara Rúbia Ignácio de Freitas +2 more
doaj +1 more source
Frequent intra-subtype recombination among HIV-1 circulating in Tanzania. [PDF]
The study estimated the prevalence of HIV-1 intra-subtype recombinant variants among female bar and hotel workers in Tanzania. While intra-subtype recombination occurs in HIV-1, it is generally underestimated.
Kiwelu, Ireen E +33 more
core +1 more source
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway
The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors
Valerie Le Sage +3 more
doaj +1 more source
. Background:. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine can induce a potent cellular and humoral immune response to protect against SARS-CoV-2 infection.
Xiaodong Yang +14 more
doaj +1 more source
HIV-1 transmissions during asymptomatic infection : exploring the impact of changes in HIV-1 viral load due to coinfections [PDF]
High HIV-1 plasma viral loads (PVLs) in sub-Saharan Africa, partly because of high rates of coinfection, may have been one of the drivers of the “explosive” epidemics seen in that region.
Baggaley, Rebecca F +3 more
core +1 more source
HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases
HIV-1 co-opts several host machinery to generate a permissive environment for viral replication and transmission. In this work we reveal how HIV-1 impacts the host translation and intracellular vesicular trafficking machineries for protein synthesis and ...
Alessandro Cinti +8 more
doaj +1 more source
Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription [PDF]
Abstract Background Transcription of HIV-1 genes is activated by HIV-1 Tat protein, which induces phosphorylation of RNA polymerase II (RNAPII) C-terminal domain (CTD) by CDK9/cyclin T1. Earlier we showed that CDK2/cyclin E phosphorylates HIV-1 Tat in vitro.
Gordeuk Victor R +9 more
openaire +3 more sources

