Results 21 to 30 of about 867,008 (306)

Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway

Viruses, 2016
The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors
Valerie Le Sage, Alessandro Cinti, Raquel Amorim, Andrew J. Mouland   +3 more
doaj   +1 more source

Primary HIV-1 Infection Among Infants in sub-Saharan Africa: HPTN 024. [PDF]

, 2009
Our objectives were to assess clinical signs and diagnoses associated with primary HIV-1 infection among infants. We analyzed data from a clinical trial (HIV Prevention Trials Network Protocol 024) in sub-Saharan Africa.
Anthony Mwatha, Barbra Richardson, Bollinger, Boom, Chasela, Daar, Guay, Hecht, Horwood, Irving Hoffman, Jennifer S Read, Jones, Kahn, Karim Manji, Kinloch-de Loes, Lavreys, Lepage, Lynda Emel, Megan Valentine, Nozyce, Richardson, Robert L Goldenberg, Rouet, Schacker, Taha, Taha E Taha, Usha Sharma   +26 more
core   +2 more sources

HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases

Scientific Reports, 2017
HIV-1 co-opts several host machinery to generate a permissive environment for viral replication and transmission. In this work we reveal how HIV-1 impacts the host translation and intracellular vesicular trafficking machineries for protein synthesis and ...
Alessandro Cinti, Valerie Le Sage, Miroslav P. Milev, Fernando Valiente-Echeverría, Christina Crossie, Marie-Joelle Miron, Nelly Panté, Martin Olivier, Andrew J. Mouland   +8 more
doaj   +1 more source

Depicting HIV-1 Transcriptional Mechanisms: A Summary of What We Know

Viruses, 2020
Despite the introduction of combinatory antiretroviral therapy (cART), HIV-1 infection cannot be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is interrupted, a rapid rebound of viremia is observed.
Antoine Dutilleul, Anthony Rodari, Carine Van Lint   +2 more
doaj   +1 more source

Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation [PDF]

, 2006
APOBEC3G and APOBEC3F restrict human immunodeficiency virus type 1 (HIV-1) replication in vitro through the induction of G!92A hypermutation; however, the relevance of this host antiviral strategy to clinical HIV-1 is currently not known.
Pace, C., Keller, J., Nolan, D., James, I., Gaudieri, S., Moore, C., Mallal, S.   +6 more
core   +2 more sources

Hiding in plain sight – platelets, the silent carriers of HIV-1

Platelets, 2021
There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination antiretroviral therapy (cART) this has dramatically reduced mortality and morbidity with prevention ...
Yvonne Baumer, Tina M. Weatherby, Brooks I. Mitchell, Ivo N. SahBandar, Thomas A. Premeaux, D’Antoni Michelle L., Cristhian A. Gutierrez-Huerta, Tiffany M. Powell-Wiley, Timothy R. Brown, William A. Boisvert, Cecilia M. Shikuma, Lishomwa C. Ndhlovu   +11 more
doaj   +1 more source

Immune compromise in HIV-1/HTLV-1 coinfection with paradoxical resolution of CD4 lymphocytosis during antiretroviral therapy: a case report [PDF]

, 2015
Human immunodeficiency virus type-1 (HIV-1) and human T lymphotropic virus type-1 (HTLV-1) infections have complex effects on adaptive immunity, with specific tropism for, but contrasting effects on, CD4 T lymphocytes: depletion with HIV-1, proliferation
Bangham, C, Basnayake, S, Cook, L, Kagdi, H, Pozniak, A, Rockwood, N, Taylor, GP   +6 more
core   +2 more sources

Everything counts - a method to determine viral suppression among people living with HIV using longitudinal data for the HIV care continuum - results of two large, German, multi-center real-life cohort studies over 20 years (1999–2018)

BMC Public Health, 2021
Background The aim of this study was to develop a standardized method to reconstruct persons’ individual viral load (VL) courses to determine viral suppression and duration of viremia for the HIV care continuum in Germany using longitudinal cohort data ...
Daniel Schmidt, Christian Kollan, Matthias Stoll, Osamah Hamouda, Viviane Bremer, Tobias Kurth, Barbara Bartmeyer, the HIV-1 Seroconverter cohort, the ClinSurv HIV cohort   +8 more
doaj   +1 more source

HIV-1 induces in vivo platelet activation by enhancing platelet NOX2 activity. [PDF]

, 2015
OBJECTIVES: HIV-1 patients show increased platelet activation, but the mechanisms involved are not completely clarified. We speculated that HIV-1 might induce in vivo platelet activation by enhancing platelet NOX2-related oxidative stress.
Bartimoccia, Simona, Carnevale, Roberto, Di Campli, Francesco, Esposito, Antonella, Fantauzzi, Alessandra, Mezzaroma, Ivano, Novo, Marta, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +9 more
core   +1 more source

Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages

Retrovirology, 2019
Background Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression.
Shringar Rao, Raquel Amorim, Meijuan Niu, Yann Breton, Michel J. Tremblay, Andrew J. Mouland   +5 more
doaj   +1 more source