Results 1 to 10 of about 30,642,264 (240)

The forces driving clonal expansion of the HIV-1 latent reservoir

Virology Journal, 2020
Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral load to clinically undetectable levels, viral rebound inevitably occurs once ART is interrupted.
Runxia Liu, Francesco R. Simonetti, Ya-Chi Ho   +2 more
doaj   +1 more source

Exploring potential associations between the human microbiota and reservoir of latent HIV

Retrovirology
Background The rapid establishment and persistence of latent HIV-1 reservoirs is one of the main obstacles towards an HIV cure. While antiretroviral therapy supresses viral replication, it does not eradicate the latent reservoir of HIV-1-infected cells ...
Nel Marín-Sánchez, Roger Paredes, Alessandra Borgognone   +2 more
doaj   +1 more source

The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure

Journal of Virus Eradication, 2016
The mechanisms for the establishment and the persistence of the latent HIV-1 reservoir remain to be completely defined. HIV-1 infection is characterised by the integration of the reverse transcribed proviral DNA into the host's genome.
Maja Kiselinova, Ward De Spiegelaere, Linos Vandekerckhove   +2 more
doaj   +1 more source

Factors associated with unquantifiable total HIV-1 DNA in peripheral blood in persons living with HIV: An observational study

Journal of Virus Eradication
Background: The human immunodeficiency virus type 1 (HIV-1) cannot be eradicated even with suppressive antiretroviral therapy because its retrotranscribed genome integrates into the DNA of host cells, creating a long-term reservoir.
Aurélie Ram, Vanessa Rascon Velasco, Gilbert Mchantaf, Véronique Avettand-Fénoël, Jean-Paul Viard   +4 more
doaj   +1 more source

CD4-mimetics sensitize HIV-infected cells to ADCC mediated by plasma from persons with early-stage HIV-1 infection

Journal of Virology
The viral reservoir in long-lived memory CD4+ cells, established in the early stages of HIV infection, represents the main obstacle to an HIV cure. Some strategies being developed to target the reservoir rely on rendering HIV-1 envelope glycoproteins ...
Shilei Ding, Alexandra Tauzin, Delia Pinto-Santini, Sayan Dasgupta, Derek Yang, William D. Tolbert, Monika Chandravanshi, Mehdi Benlarbi, Myriam Verly, Javier R. Lama, Donna M. Huryn, Amos B. Smith, Marzena Pazgier, Andrés Finzi, Ann Duerr   +14 more
doaj   +1 more source

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency

Frontiers in Cellular and Infection Microbiology, 2023
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +1 more source

Reservoir differences across HIV-1 subtypes: a systematic review to guide cure research

Frontiers in Immunology
IntroductionDespite effective antiretroviral therapy, HIV-1 persists as a viral reservoir and remains a major barrier to a durable cure. Reservoir size and dynamics are central determinants of the success of cure strategies.
Myrthe S. Willemsen, Myrthe S. Willemsen, Anniek A. N. Tanja, Sody Munsaka, Damalie Nakanjako, Damalie Nakanjako, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Maria A. Papathanasopoulos, Kevin Jenniskens, Kevin Jenniskens, Giulia Sinatti, Giulia Sinatti, Jori Symons, Annemarie M. J. Wensing, Monique Nijhuis, Monique Nijhuis, Ganna Rozhnova, Ganna Rozhnova, Ganna Rozhnova, Ganna Rozhnova   +22 more
doaj   +1 more source

Corrigendum: Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency

Frontiers in Cellular and Infection Microbiology, 2023
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +1 more source

Protein post-translational modification regulates HIV-1 latency

生物医学转化
AIDS is a disease named acquired immunodeficiency syndrome, which caused by the human immunodeficiency virus (HIV). HIV can be divided into HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is a global pandemic that has caused serious harm.
Wu Tong, Wang Tiantian, Deng Kai
doaj   +1 more source

Latency Reversing Agents and the Road to an HIV Cure

Pathogens
HIV-1 infection cannot be cured due to the presence of HIV-1 latently infected cells. These cells do not produce the virus, but they can resume virus production at any time in the absence of antiretroviral therapy. Therefore, people living with HIV (PLWH)
Louis Tioka, Rafael Ceña Diez, Anders Sönnerborg, Maarten A. A. van de Klundert   +3 more
doaj   +1 more source