Inducible HIV-1 Reservoir Reduction Assay (HIVRRA), a Fast and Sensitive Assay to Test Cytotoxicity and Potency of Cure Strategies to Reduce the Replication-Competent HIV-1 Reservoir in Ex Vivo PBMCs [PDF]
Bio-ProtocolThe HIV-1 reservoir, consisting of transcriptionally silent integrated HIV-1 proviruses, is a major barrier to a cure, as it persists during effective antiretroviral therapy (ART) and is the source of viral rebound upon treatment interruption.
Jade Jansen +2 more
doaj +2 more sources
Atlas of the HIV-1 Reservoir in Peripheral CD4 T Cells of Individuals on Successful Antiretroviral Therapy [PDF]
mBio, 2021 Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Cristina Gálvez +6 more
doaj +2 more sources
Linking gut microbiome to HIV-1 reservoir size in people living with HIV [PDF]
Gut PathogensThe gut microbiome is altered during HIV-1 infection and contributes to immune dysfunction and inflammation in people living with HIV (PLWH), these changes may persist despite effective antiretroviral therapy (ART).
Oscar Kieri +7 more
doaj +2 more sources
Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA [PDF]
Frontiers in Microbiology, 2021 The presence of a stable HIV-1 reservoir persisting over time despite effective antiretroviral suppression therapy precludes a cure for HIV-1. Characterizing and quantifying this residual reservoir is considered an essential prerequisite to develop and ...
Cynthia Lungu +3 more
doaj +2 more sources
BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4+ T cells [PDF]
Cell Reports MedicineSummary: Despite antiretroviral therapy, HIV-1 mainly persists in memory CD4+ T cells in people living with HIV-1. Most long-lived viral reservoir cells are infected by the virus near the time of therapy initiation.
Hongbo Gao +15 more
doaj +2 more sources
Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence
Viruses, 2020 While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Laurens Lambrechts +4 more
doaj +3 more sources
Noncanonical-NF-κB activation and DDX3 inhibition reduces the HIV-1 reservoir by elimination of latently infected cells ex-vivo [PDF]
Microbiology SpectrumLatency reversal and subsequent elimination of the human immunodeficiency virus-1 (HIV-1) reservoir using a combination of compounds with different mechanisms of action are considered a promising tool for HIV-1 cure.
Jade Jansen +8 more
doaj +2 more sources
Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts [PDF]
Nature CommunicationsEliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene expression on HIV-1 reservoir size during suppressive antiretroviral ...
Philip K. Ehrenberg +33 more
doaj +2 more sources
Spatial technologies to evaluate the HIV-1 reservoir and its microenvironment in the lymph node [PDF]
mBioThe presence of the HIV-1 reservoir, a group of immune cells that contain intact, integrated, and replication-competent proviruses, is a major challenge to cure HIV-1.
Fatima Zaman +5 more
doaj +2 more sources
Assessing advances in three decades of clinical antiretroviral therapy on the HIV-1 reservoir [PDF]
The Journal of Clinical InvestigationBACKGROUND Antiretroviral therapy (ART) has improved the clinical management of HIV-1 infection. However, little is known about how the latest ART recommendations affect the heterogeneity of the HIV-1 reservoir size.METHODS We used a complete statistical
Irene González-Navarro +18 more
doaj +2 more sources