Results 31 to 40 of about 30,642,264 (240)

Immune activation and exhaustion marker expression on T-cell subsets in ART-treated adolescents and young adults with perinatal HIV-1 infection as correlates of viral persistence

Frontiers in Immunology, 2023
HIV-1 infection in memory CD4+ T cells forms a latent reservoir that is a barrier to cure. Identification of immune biomarkers that correlate with HIV-1 reservoir size may aid with evaluating efficacy of HIV-1 eradication strategies, towards ART-free ...
Yuyang Huang, Adit Dhummakupt, Priya Khetan, Tricia Nilles, Weiqiang Zhou, Prakriti Mudvari, Joseph Szewczyk, Ya Hui Chen, Eli Boritz, Hongkai Ji, Allison Agwu, Deborah Persaud, Deborah Persaud   +12 more
doaj   +1 more source

The Impact of Cellular Proliferation on the HIV-1 Reservoir [PDF]

Viruses, 2020
Human immunodeficiency virus (HIV) is a chronic infection that destroys the immune system in infected individuals. Although antiretroviral therapy is effective at preventing infection of new cells, it is not curative. The inability to clear infection is due to the presence of a rare, but long-lasting latent cellular reservoir.
Maria C. Virgilio, Kathleen L. Collins
openaire   +3 more sources

Characteristics, immunological response & treatment outcomes of HIV-2 compared with HIV-1 & dual infections (HIV 1/2) in Mumbai. [PDF]

, 2010
BACKGROUND AND OBJECTIVES: Information available on HIV-2 and dual infection (HIV-1/2) is limited. This study was carried out among HIV positive individuals in an urban referral clinic in Khar, Mumbai, India, to report on relative proportions of HIV-1 ...
Manzi, M, Harries, AD, Rony, Zachariah, Ladomirska, Joanna, Wilson, N, Bhanumati, Varghese, Alaka, Deshpande, Homa, Mansoor, Chiara, Montaldo   +8 more
core   +6 more sources

Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda

Retrovirology, 2022
Background Our understanding of the peripheral human immunodeficiency virus type 1 (HIV-1) reservoir is strongly biased towards subtype B HIV-1 strains, with only limited information available from patients infected with non-B HIV-1 subtypes, which are ...
Samira Joussef-Piña, Immaculate Nankya, Sophie Nalukwago, Joy Baseke, Sandra Rwambuya, Dane Winner, Fred Kyeyune, Keith Chervenak, Bonnie Thiel, Robert Asaad, Curtis Dobrowolski, Benjamin Luttge, Blair Lawley, Cissy M. Kityo, W. Henry Boom, Jonathan Karn, Miguel E. Quiñones-Mateu   +16 more
doaj   +1 more source

Targeting the Latent Reservoir for HIV-1 [PDF]

Immunity, 2018
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within weeks of treatment interruption. The major barrier to a cure is a small pool of resting memory CD4+ T cells that harbor latent HIV-1 proviruses.
Srona, Sengupta, Robert F, Siliciano
openaire   +2 more sources

Long-lived reservoirs of HIV-1 [PDF]

Trends in Microbiology, 2014
HIV-1 persistence in long-lived cellular reservoirs remains a major barrier to a cure. In a recent Nature Medicine paper, Buzon et al. identify memory T cells with stem cell-like properties (TSCM) that harbor infectious provirus and that likely contribute to HIV-1 persistence.
Thomas D, Zaikos, Kathleen L, Collins
openaire   +2 more sources

Heterogeneity of HIV-1 latent reservoirs

Chinese Medical Journal, 2020
Abstract Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses.
Jia-Cong Zhao, Kai Deng, Peng Lyu, Xin Chen.   +3 more
openaire   +3 more sources

HIV-1 Latent Reservoir: Size Matters [PDF]

Future Virology, 2016
More than 35 million people remain infected with HIV-1. Upon antiretroviral therapy cessation, HIV-1-positive individuals systematically fail to achieve sustained virological remission, revealing the presence of a reservoir. This reservoir takes into account anatomical sanctuaries where HIV-1 continues to replicate, and latently infected cells also ...
Hodel, F., Patxot, M., Snäkä, T., Ciuffi, A.   +3 more
openaire   +4 more sources

Visualization of HIV-1 reservoir: an imaging perspective. [PDF]

Curr Opin HIV AIDS, 2021
Purpose of review The persistence of HIV-1-infected cells, despite the introduction of the combinatorial antiretroviral therapy, is a major obstacle to HIV-1 eradication. Understanding the nature of HIV reservoir will lead to novel therapeutic approaches for the functional cure or eradication of the virus.
Chapon C, Moysi E, Naninck T, Mayet C, Petrovas C.   +4 more
europepmc   +3 more sources

Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir [PDF]

, 2016
Objective: HIV-1 reservoirs are the major hurdle to virus clearance in combination antiretroviral therapy (cART)-Treated patients. An approach to eradicating HIV-1 involves reversing latency in cART-Treated patients to make latent cells visible to the ...
De Wit, S, Rohr, O, Rohr, O. (Olivier), Van Lint, C. (Carine), De Wit, S. (Stéphane), Van Lint, Carine, Darcis, Gilles, De Wit, Stéphane, Rouzioux, C, Vanhulle, C. (Caroline), Bouchat, S, Kula, Anna, Delacourt, Nadège, Bouchat, S. (Sophie), Vanhulle, Caroline, Delacourt, N, Rouzioux, C. (Christine), Darcis, G. (Gilles), Rohr, Olivier, Rouzioux, Christine, Van Driessche, Benoît, Avettand-Fenoel, Veronique, Vanhulle, C, Avettand-Fenoel, V. (Véronique), Van Driessche, B, Delacourt, N. (Nadège), Bouchat, Sophie, Van Driessche, B. (Benoit), Kula, A. (Anna)   +28 more
core   +1 more source