Results 11 to 20 of about 34,607 (204)

Specific quantification of inducible HIV-1 reservoir by RT-LAMP [PDF]

Communications Medicine
Background Strategies toward HIV-1 cure aim to clear, inactivate, reduce, or immunologically control the virus from a pool of latently infected cells such that combination antiretroviral therapy (cART) can be safely interrupted.
Tanvir Hossain, Cynthia Lungu, Sten de Schrijver, Mamokoena Kuali, Raquel Crespo, Nicole Reddy, Ayanda Ngubane, Tsung Wai Kan, Kavidha Reddy, Shringar Rao, Robert-Jan Palstra, Paradise Madlala, Thumbi Ndung’u, Tokameh Mahmoudi   +13 more
doaj   +2 more sources

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

mBio, 2022
Human immunodeficiency virus type 1 (HIV-1) can integrate viral DNA into host cell chromosomes to establish a long-term stable latent reservoir, which is a major obstacle to cure HIV-1 infection. The characteristics of the HIV-1 latent reservoir have not
Wanying Zhang, Mo Zhou, Cancan Chen, Shiyu Wu, Lilin Wang, Baijin Xia, Jun Liu, Xiancai Ma, Ting Pan, Hui Zhang, Linghua Li, Bingfeng Liu   +11 more
doaj   +1 more source

Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays

Viruses, 2022
Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal ...
Priya Khetan, Yufeng Liu, Adit Dhummakupt, Deborah Persaud   +3 more
doaj   +1 more source

Hiding in plain sight – platelets, the silent carriers of HIV-1

Platelets, 2021
There are approximately 38 million people globally living with Human immunodeficiency virus 1 (HIV-1) and given the tremendous success of combination antiretroviral therapy (cART) this has dramatically reduced mortality and morbidity with prevention ...
Yvonne Baumer, Tina M. Weatherby, Brooks I. Mitchell, Ivo N. SahBandar, Thomas A. Premeaux, D’Antoni Michelle L., Cristhian A. Gutierrez-Huerta, Tiffany M. Powell-Wiley, Timothy R. Brown, William A. Boisvert, Cecilia M. Shikuma, Lishomwa C. Ndhlovu   +11 more
doaj   +1 more source

Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda

Retrovirology, 2022
Background Our understanding of the peripheral human immunodeficiency virus type 1 (HIV-1) reservoir is strongly biased towards subtype B HIV-1 strains, with only limited information available from patients infected with non-B HIV-1 subtypes, which are ...
Samira Joussef-Piña, Immaculate Nankya, Sophie Nalukwago, Joy Baseke, Sandra Rwambuya, Dane Winner, Fred Kyeyune, Keith Chervenak, Bonnie Thiel, Robert Asaad, Curtis Dobrowolski, Benjamin Luttge, Blair Lawley, Cissy M. Kityo, W. Henry Boom, Jonathan Karn, Miguel E. Quiñones-Mateu   +16 more
doaj   +1 more source

Immune activation and exhaustion marker expression on T-cell subsets in ART-treated adolescents and young adults with perinatal HIV-1 infection as correlates of viral persistence

Frontiers in Immunology, 2023
HIV-1 infection in memory CD4+ T cells forms a latent reservoir that is a barrier to cure. Identification of immune biomarkers that correlate with HIV-1 reservoir size may aid with evaluating efficacy of HIV-1 eradication strategies, towards ART-free ...
Yuyang Huang, Adit Dhummakupt, Priya Khetan, Tricia Nilles, Weiqiang Zhou, Prakriti Mudvari, Joseph Szewczyk, Ya Hui Chen, Eli Boritz, Hongkai Ji, Allison Agwu, Deborah Persaud, Deborah Persaud   +12 more
doaj   +1 more source

The Impact of Cellular Proliferation on the HIV-1 Reservoir [PDF]

Viruses, 2020
Human immunodeficiency virus (HIV) is a chronic infection that destroys the immune system in infected individuals. Although antiretroviral therapy is effective at preventing infection of new cells, it is not curative. The inability to clear infection is due to the presence of a rare, but long-lasting latent cellular reservoir.
Maria C. Virgilio, Kathleen L. Collins
openaire   +3 more sources

Long-lived reservoirs of HIV-1 [PDF]

Trends in Microbiology, 2014
HIV-1 persistence in long-lived cellular reservoirs remains a major barrier to a cure. In a recent Nature Medicine paper, Buzon et al. identify memory T cells with stem cell-like properties (TSCM) that harbor infectious provirus and that likely contribute to HIV-1 persistence.
Thomas D, Zaikos, Kathleen L, Collins
openaire   +2 more sources

Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir. [PDF]

Cell Host Microbe, 2021
Small CD4-mimetic compounds (CD4mc) sensitize HIV-1-infected cells to antibody-dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that are otherwise occluded on the unliganded viral envelope (Env). Combining CD4mc with two families of CD4-induced (CD4i) antibodies, which are frequently found in plasma of HIV-1 ...
Rajashekar JK, Richard J, Beloor J, Prévost J, Anand SP, Beaudoin-Bussières G, Shan L, Herndler-Brandstetter D, Gendron-Lepage G, Medjahed H, Bourassa C, Gaudette F, Ullah I, Symmes K, Peric A, Lindemuth E, Bibollet-Ruche F, Park J, Chen HC, Kaufmann DE, Hahn BH, Sodroski J, Pazgier M, Flavell RA, Smith AB, Finzi A, Kumar P.   +26 more
europepmc   +4 more sources

Visualization of HIV-1 reservoir: an imaging perspective. [PDF]

Curr Opin HIV AIDS, 2021
Purpose of review The persistence of HIV-1-infected cells, despite the introduction of the combinatorial antiretroviral therapy, is a major obstacle to HIV-1 eradication. Understanding the nature of HIV reservoir will lead to novel therapeutic approaches for the functional cure or eradication of the virus.
Chapon C, Moysi E, Naninck T, Mayet C, Petrovas C.   +4 more
europepmc   +3 more sources