Results 11 to 20 of about 30,642,264 (240)

Inducible HIV-1 Reservoir Reduction Assay (HIVRRA), a Fast and Sensitive Assay to Test Cytotoxicity and Potency of Cure Strategies to Reduce the Replication-Competent HIV-1 Reservoir in Ex Vivo PBMCs [PDF]

Bio-Protocol
The HIV-1 reservoir, consisting of transcriptionally silent integrated HIV-1 proviruses, is a major barrier to a cure, as it persists during effective antiretroviral therapy (ART) and is the source of viral rebound upon treatment interruption.
Jade Jansen, Teunis Geijtenbeek, Neeltje Kootstra   +2 more
doaj   +2 more sources

Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA [PDF]

Frontiers in Microbiology, 2021
The presence of a stable HIV-1 reservoir persisting over time despite effective antiretroviral suppression therapy precludes a cure for HIV-1. Characterizing and quantifying this residual reservoir is considered an essential prerequisite to develop and ...
Cynthia Lungu, Riddhima Banga, Rob A. Gruters, Francesco A. Procopio   +3 more
doaj   +3 more sources

Atlas of the HIV-1 Reservoir in Peripheral CD4 T Cells of Individuals on Successful Antiretroviral Therapy [PDF]

mBio, 2021
Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Cristina Gálvez, Judith Grau-Expósito, Victor Urrea, Bonaventura Clotet, Vicenç Falcó, Maria José Buzón, Javier Martinez-Picado   +6 more
doaj   +2 more sources

Linking gut microbiome to HIV-1 reservoir size in people living with HIV [PDF]

Gut Pathogens
The gut microbiome is altered during HIV-1 infection and contributes to immune dysfunction and inflammation in people living with HIV (PLWH), these changes may persist despite effective antiretroviral therapy (ART).
Oscar Kieri, Aswathy Narayanan, Bianca B Jütte, Peter Svensson, Soo Aleman, Anders Sönnerborg, Shilpa Ray, Piotr Nowak   +7 more
doaj   +2 more sources

BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4+ T cells [PDF]

Cell Reports Medicine
Summary: Despite antiretroviral therapy, HIV-1 mainly persists in memory CD4+ T cells in people living with HIV-1. Most long-lived viral reservoir cells are infected by the virus near the time of therapy initiation.
Hongbo Gao, Yuhao Li, Ritudwhaj Tiwari, Marilia Pinzone, Xiwen Qin, Kolin M. Clark, Sara K. Nicholson, Tony Yao, Kelly Rome, Michael Scaglione, Will Bailis, Rachel M. Presti, Irini Sereti, Naresha Saligrama, Leyao Wang, Liang Shan   +15 more
doaj   +2 more sources

HIV-1 DNA and the HIV-1 Viral Reservoir [PDF]

, 2013
HIV-1 infected resting memory CD4+ T cells are major contributors to the HIV-1 viral reservoir, which is established during early infection, maintaining HIV-1 infection for an individual s life. The effect the timing of therapy initiation has on the size
McBride, Kristin
core   +3 more sources

HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up studyResearch in context [PDF]

EBioMedicine
Summary: Background: Despite effective suppression of HIV-1 replication by antiretroviral therapy (ART), persistent viral reservoirs prevent cure and necessitate lifelong treatment.
Cynthia Lungu, Tanvir Hossain, Raquel Crespo, Henrieke A.B. Prins, Kathryn S. Hensley, Casper Rokx, Shringar Rao, Jeroen J.A. van Kampen, David A.M.C. van de Vijver, Thibault Mesplède, Peter D. Katsikis, Rob A. Gruters, Yvonne M. Mueller, Tokameh Mahmoudi   +13 more
doaj   +2 more sources

Noncanonical-NF-κB activation and DDX3 inhibition reduces the HIV-1 reservoir by elimination of latently infected cells ex-vivo [PDF]

Microbiology Spectrum
Latency reversal and subsequent elimination of the human immunodeficiency virus-1 (HIV-1) reservoir using a combination of compounds with different mechanisms of action are considered a promising tool for HIV-1 cure.
Jade Jansen, Stefanie Kroeze, Shirley Man, Matteo Andreini, Jan-Willem Bakker, Claudio Zamperini, Alessia Tarditi, Neeltje A. Kootstra, Teunis B. H. Geijtenbeek   +8 more
doaj   +2 more sources

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART [PDF]

Nature Communications, 2020
The HIV reservoir is a major hurdle for a cure of HIV, but the factors determining its size and dynamics remain unclear. Here the authors show in a large cohort of 610 HIV-1 infected individuals, who are on suppressive ART for a median of 5.4 years, that
Chenjie Wan, Nadine Bachmann, Venelin Mitov, François Blanquart, Susana Posada Céspedes, Teja Turk, Kathrin Neumann, Niko Beerenwinkel, Jasmina Bogojeska, Jacques Fellay, Volker Roth, Jürg Böni, Matthieu Perreau, Thomas Klimkait, Sabine Yerly, Manuel Battegay, Laura Walti, Alexandra Calmy, Pietro Vernazza, Enos Bernasconi, Matthias Cavassini, Karin J. Metzner, Huldrych F. Günthard, Roger D. Kouyos, the Swiss HIV Cohort Study   +24 more
doaj   +4 more sources

Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts [PDF]

Nature Communications
Eliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene expression on HIV-1 reservoir size during suppressive antiretroviral ...
Philip K. Ehrenberg, Aviva Geretz, Meta Volcic, Taisuke Izumi, Lauren K. Yum, Adam Waickman, Shida Shangguan, Dominic Paquin-Proulx, Matthew Creegan, Meera Bose, Kawthar Machmach, Aidan McGraw, Akshara Narahari, Jeffrey R. Currier, Carlo Sacdalan, Nittaya Phanuphak, Richard Apps, Michael Corley, Lishomwa C. Ndhlovu, Bonnie Slike, Shelly J. Krebs, Jintanat Anonworanich, Sodsai Tovanabutra, Merlin L. Robb, Michael A. Eller, Gregory M. Laird, Joshua Cyktor, Eric S. Daar, Trevor A. Crowell, John W. Mellors, Sandhya Vasan, Nelson L. Michael, Frank Kirchhoff, Rasmi Thomas   +33 more
doaj   +2 more sources