Results 1 to 10 of about 156,401 (159)

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence [PDF]

Viruses, 2020
While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Laurens Lambrechts, Basiel Cole, Sofie Rutsaert, Wim Trypsteen, Linos Vandekerckhove   +4 more
doaj   +3 more sources

Highlights from the HIV Cure and Reservoir Symposium, 11–12 September 2017, Ghent, Belgium [PDF]

Journal of Virus Eradication, 2018
For the second time, the HIV Cure Research Center (HCRC) at Ghent University organised the HIV Cure and Reservoir Symposium, in Ghent, Belgium, where in this two-day conference, virologists, molecular biologists, immunologists and clinicians presented ...
Sam Kint, Clarissa Van Hecke, Basiel Cole, Linos Vandekerckhove, Magdalena Sips   +4 more
doaj   +3 more sources

Digital PCR as a tool to measure HIV persistence [PDF]

Retrovirology, 2018
Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped.
Sofie Rutsaert, Kobus Bosman, Wim Trypsteen, Monique Nijhuis, Linos Vandekerckhove   +4 more
doaj   +3 more sources

NF-κB sub-pathways and HIV cure: A revisit

EBioMedicine, 2021
HIV cure is thwarted by the presence of quiescent yet replication competent HIV-1 (HIV). Antiretroviral therapy (ART) is unable to eradicate reservoirs, and upon cessation of ART, HIV will rebound.
Lilly M. Wong, Guochun Jiang
doaj   +3 more sources

Participation in HIV cure-related research: a scoping review of the proxy literature and implications for future research

Journal of Virus Eradication, 2015
Objective: To identify the main types of HIV cure-related strategies and examine possible risks (and benefits) associated with participating in HIV cure-related research studies.
Karine Dubé, Catalina Ramirez, Jessica Handibode, Jeffrey Taylor, Asheley Skinner, Sandra Greene, Joseph D. Tucker   +6 more
doaj   +3 more sources

Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons

mBio, 2022
Coronavirus disease 2019 (COVID-19) is frequently associated with neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces these effects remains unclear.
Weili Kong, Mauricio Montano, Michael J. Corley, Ekram Helmy, Hirofumi Kobayashi, Martin Kinisu, Rahul Suryawanshi, Xiaoyu Luo, Loic A. Royer, Nadia R. Roan, Melanie Ott, Lishomwa C. Ndhlovu, Warner C. Greene   +12 more
doaj   +1 more source

Nonhuman Primate Models for HIV Cure Research [PDF]

, 2012
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Cristian Apetrei, Ivona Pandrea, John W. Mellors, Richard A. Koup   +3 more
core   +8 more sources

Vorinostat Renders the Replication-Competent Latent Reservoir of Human Immunodeficiency Virus (HIV) Vulnerable to Clearance by CD8 T Cells

EBioMedicine, 2017
Latently human immunodeficiency virus (HIV)-infected cells are transcriptionally quiescent and invisible to clearance by the immune system. To demonstrate that the latency reversing agent vorinostat (VOR) induces a window of vulnerability in the latent ...
Julia A. Sung, Katherine Sholtis, Jennifer Kirchherr, Joann D. Kuruc, Cynthia L. Gay, Jeffrey L. Nordstrom, Catherine M. Bollard, Nancie M. Archin, David M. Margolis   +8 more
doaj   +1 more source

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"? [PDF]

, 2016
With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The
Cannon, Paula M, Currier, Judith S, Douek, Daniel C, June, Carl H, Kiem, Hans Peter, Kuritzkes, Daniel R, Lederman, Michael M, Lewin, Sharon R, Margolis, David M, McCune, Joseph M, Mellors, John W, Schacker, Timothy W, Sekaly, Rafick P, Tebas, Pablo, Walker, Bruce D   +14 more
core   +2 more sources

The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter. [PDF]

, 2019
A major challenge in finding a cure for HIV-1/AIDS is the difficulty in identifying and eradicating persistent reservoirs of replication-competent provirus.
Chang, Kungyen, Chao, Ti-Chun, Karris, Maile Ann Young, Kaul, Marcus, Li, Zhonghan, Qin, Yue, Rana, Tariq M, Sanchez, Ana, Singh, Gatikrushna, Tiwari, Shashi Kant, Yau, Edwin, Zhang, Qiong   +11 more
core   +1 more source