Results 11 to 20 of about 156,550 (306)

Addressing an HIV cure in LMIC [PDF]

Retrovirology, 2021
AbstractHIV-1 persists in infected individuals despite years of antiretroviral therapy (ART), due to the formation of a stable and long-lived latent viral reservoir. Early ART can reduce the latent reservoir and is associated with post-treatment control in people living with HIV (PLWH). However, even in post-treatment controllers, ART cessation after a
Ismail, Sherazaan D, Pankrac, Joshua, Ndashimye, Emmanuel, Prodger, Jessica L, Abrahams, Melissa-Rose, Mann, Jamie F S, Redd, Andrew D, Arts, Eric J   +7 more
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A new hypothesis on HIV cure [PDF]

F1000Research, 2015
In this opinion article, I provide the rationale for my hypothesis that nucleoside reverse transcriptase inhibitors (NRTIs) may prevent human immunodeficiency virus (HIV) cure by promoting the survival of cells with integrated provirus. If correct, we may be closer to a cure than we realize.
openaire   +3 more sources

Controversies in HIV cure research [PDF]

Journal of the International AIDS Society, 2012
BackgroundAntiretroviral therapy significantly reduces HIV viral burden and prolongs life, but does not cure HIV infection. The major scientific barrier to a cure is thought to be the persistence of the virus in cellular and/or anatomical reservoirs.DiscussionMost efforts to date, including pharmaco, immuno or gene therapy, have failed to cure patients,
Johnston, Rowena, Barré-Sinoussi, Françoise   +1 more
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A BAF’ling Approach to Curing HIV [PDF]

Cell Chemical Biology, 2018
Latency is the primary barrier to the development of a long-sought cure for HIV-1. In this issue of Cell Chemical Biology, Marian et al., (2018) describe the development of novel compounds targeting the BAF chromatin remodeling complex to reverse HIV latency, with the potential to provide a functional cure.
Tomar, Sakshi, Ali, Ibraheem, Ott, Melanie   +2 more
openaire   +4 more sources

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir

Nature Communications, 2023
The development of latency reversing agents that potently reactivate HIV without inducing global T cell activation would benefit the field of HIV reservoir research and could pave the way to a functional cure.
Marion Pardons, Basiel Cole, Laurens Lambrechts, Willem van Snippenberg, Sofie Rutsaert, Ytse Noppe, Nele De Langhe, Annemieke Dhondt, Jerel Vega, Filmon Eyassu, Erik Nijs, Ellen Van Gulck, Daniel Boden, Linos Vandekerckhove   +13 more
doaj   +1 more source

Implications of prioritizing HIV cure: new momentum to overcome old challenges in HIV. [PDF]

, 2016
BACKGROUND: Curing HIV is a new strategic priority for several major AIDS organizations. In step with this new priority, HIV cure research and related programs are advancing in low, middle, and high-income country settings.
Gilbertson, Adam, Lo, Ying-Ru, Tucker, Joseph D, Vitória, Marco   +3 more
core   +3 more sources

A Comparison of Miltefosine and Sodium Stibogluconate for Treatment of Visceral Leishmaniasis in an Ethiopian Population with High Prevalence of HIV Infection. [PDF]

, 2006
BACKGROUND: Antimonials are the mainstay of visceral leishmaniasis (VL) treatment in Africa. The increasing incidence of human immunodeficiency virus (HIV) coinfection requires alternative safe and effective drug regimens.
Abren Dejenie, Davidson RN, Delgado J, Gerry Boots, Jo Mesure, Koert Ritmeijer, Kuhlencord A, Margriet den Boer, Medrano FJ, Meredith SE, Molina R, Robert N. Davidson, Sundar S, Tadesse Beyene Hundie, Yibeltal Assefa   +14 more
core   +2 more sources

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR. [PDF]

, 2020
Despite reductions in mortality from the use of highly active antiretroviral therapy (HAART), the presence of latent or transcriptionally silent proviruses prevents HIV cure/eradication.
Bukrinsky, Michael, Dubrovsky, Larisa, Jada, Tejaswi, Ochem, Alex, Sahu, Geetaram, Sharma, Adhikarimayum Lakhikumar, Simon, Gary, Sun, Lin, Tyagi, Mudit, Yue, Han, Zicari, Sonia   +10 more
core   +2 more sources

Stem-cell-based gene therapy for HIV infection. [PDF]

, 2013
Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection.
Kitchen, Scott, Zhen, Anjie
core   +2 more sources

Barriers to a cure for HIV in women [PDF]

Journal of the International AIDS Society, 2016
IntroductionDistinct biological factors exist that affect the natural history of HIV and the host immune response between women and men. These differences must be addressed to permit the optimal design of effective HIV eradication strategies for much of the HIV‐positive population.Methods and resultsHere, we review the literature on sex‐based ...
Gianella, Sara, Tsibris, Athe, Barr, Liz, Godfrey, Catherine   +3 more
openaire   +6 more sources