Results 11 to 20 of about 58,279 (299)

Controversies in HIV cure research [PDF]

Journal of the International AIDS Society, 2012
BackgroundAntiretroviral therapy significantly reduces HIV viral burden and prolongs life, but does not cure HIV infection. The major scientific barrier to a cure is thought to be the persistence of the virus in cellular and/or anatomical reservoirs.DiscussionMost efforts to date, including pharmaco, immuno or gene therapy, have failed to cure patients,
Johnston, Rowena, Barré-Sinoussi, Françoise   +1 more
openaire   +5 more sources

Animal Models for HIV Cure Research [PDF]

Frontiers in Immunology, 2016
The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot clear the virus from the infected patient. A cure for HIV-1 is badly needed to stop both the spread of the virus in human populations and disease progression in infected ...
Policicchio, Benjamin B., Pandrea, Ivona, Apetrei, Cristian   +2 more
openaire   +5 more sources

HIV Vaccines and Cure [PDF]

, 2018
Since the discovery of acquired immunodeficiency syndrome (AIDS) in 1981, it has been extremely difficult to develop an effective vaccine or a therapeutic cure despite over 36 years of global efforts.
Chen, Z
openaire   +3 more sources

HIV Cure Strategies [PDF]

, 2017
Although current antiretroviral therapy (ART) is highly effective at controlling HIV-1 replication, it does not eradicate or cure the infection. HIV-1 persists quiescently in cellular reservoirs, not detected by the immune system due to the lack of active viral replication; these reservoirs represent the major obstacle for cure approaches.
Boris Juelg, Rajesh Gandhi
openaire   +2 more sources

Towards inclusive HIV cure development: Identifying important and acceptable HIV cure attributes and strategies among people with HIV in the Netherlands. [PDF]

HIV Med
ACKNOWLEDGEMENTS The authors thank the following individuals and organizations for their contributions to this paper. First, the authors are immensely grateful to the participants who shared their time, making this research possible.
Noorman MAJ, de Wit JBF, Marcos TA, Stutterheim SE, Albers T, Jonas KJ, Den Daas C.   +6 more
europepmc   +2 more sources

Addressing an HIV cure in LMIC [PDF]

Retrovirology, 2021
AbstractHIV-1 persists in infected individuals despite years of antiretroviral therapy (ART), due to the formation of a stable and long-lived latent viral reservoir. Early ART can reduce the latent reservoir and is associated with post-treatment control in people living with HIV (PLWH). However, even in post-treatment controllers, ART cessation after a
Ismail, Sherazaan D, Pankrac, Joshua, Ndashimye, Emmanuel, Prodger, Jessica L, Abrahams, Melissa-Rose, Mann, Jamie F S, Redd, Andrew D, Arts, Eric J   +7 more
openaire   +4 more sources

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1. [PDF]

, 2022
The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1.
Pasternak, Alexander, Passaes, Caroline Pereira Bittencourt, Cicilionyte, Aurelija, Le Douce, Valentin, Van Lint, Carine, Darcis, Gilles, De Wit, Stéphane, Berkhout, Ben, Delacourt, Nadège, Pasternak, Alexander O., Verdikt, Roxane, Plant, Estelle, Vanhulle, Caroline, Avettand-Fenoel, V. ronique, Pasternak, Alexander O, Gautier, Virginie, Bendoumou, Maryam, Santangelo, Marion, Schwartz, Christian, Rohr, Olivier, Rouzioux, Christine, Nestola, Lorena, Sáez-Cirión, Asier, Avettand-Fenoel, Veronique, Ait-Ammar, Amina, Douce, Valentin Le, Necsoi, Coca, Bouchat, Sophie, Corazza, Francis, Bizet, Martin, Fuks, François   +30 more
core   +1 more source

HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure [PDF]

, 2021
Advances in antiretroviral therapy have prolonged the life of people living with HIV and diminished the level of virus in these individuals. Yet, HIV quickly rebounds after disruption and/or cessation of treatment due to significant cellular and ...
Jeffrey R. Schneider, Michelle K. Ash, Lena Al-Harthi   +2 more
core   +1 more source

A new hypothesis on HIV cure [PDF]

F1000Research, 2015
In this opinion article, I provide the rationale for my hypothesis that nucleoside reverse transcriptase inhibitors (NRTIs) may prevent human immunodeficiency virus (HIV) cure by promoting the survival of cells with integrated provirus. If correct, we may be closer to a cure than we realize.
openaire   +3 more sources

Resurgence of HIV infection among men who have sex with men in Switzerland : mathematical modelling study [PDF]

, 2012
New HIV infections in men who have sex with men (MSM) have increased in Switzerland since 2000 despite combination antiretroviral therapy (cART). The objectives of this mathematical modelling study were: to describe the dynamics of the HIV epidemic in ...
Steven Derendinger (134735), Swiss HIV, Cohort Study, Glass, T. R., Fraser, C., Steven Derendinger, Christophe Fraser (7754), Vernazza, P., Frank de Wolf, Ard van Sighem (134719), Beatriz Vidondo (134721), Martin Gebhardt, Swiss HIV Cohort Study, Beatriz Vidondo, de Wolf Frank, Derendinger Steven, van Sighem, Ard, Jeannin André, Vernazza Pietro, Heiner C Bucher, Low, N., Martin Gebhardt (134732), Nicola Low (62560), Vidondo, B., Derendinger, Steven, Pietro Vernazza (82546), De Wolf, F., Bucher, Heiner C., Bezemer, D., Tracy R. Glass (134725), Bezemer, Daniela, Jeannin, André, Gebhardt, Martin, Bucher Heiner C., Tracy R Glass, de Wolf, Frank, Vidondo, Beatriz, Heiner C. Bucher (134728), Christophe Fraser, Jeannin, A., Daniela Bezemer, Gebhardt Martin, Bezemer Daniela, Bucher, H. C., Glass, Tracy R., Pietro Vernazza, Low Nicola, van Sighem Ard, André Jeannin, Daniela Bezemer (134739), Nicola Low, Glass Tracy R., Fraser, Christophe, Derendinger, S., Vidondo Beatriz, Ard van Sighem, Gebhardt, M., André Jeannin (134737), Frank de Wolf (89583), Fraser Christophe, Vernazza, Pietro, Low, Nicola, Van Sighem, A.   +61 more
core   +1 more source