Results 31 to 40 of about 156,550 (306)

Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy. [PDF]

, 2017
Gene therapy by engineering patient's own blood cells to confer HIV resistance can potentially lead to a functional cure for AIDS. Toward this goal, we have previously developed an anti-HIV lentivirus vector that deploys a combination of shRNA, ribozyme ...
Castanotto, Daniela, Li, Haitang, Pang, Ka Ming, Rossi, John J, Scherer, Lisa   +4 more
core   +1 more source

Towards an HIV cure

Journal of the International AIDS Society, 2014
Given the challenge of delivering complex, expensive and potentially harmful antiretroviral therapy (ART) on a global level, there is intense interest in the development of short‐term, well‐tolerated regimens that allow individuals to interrupt therapy indefinitely without experiencing a rebound in viremia. This so‐called “cure” or “remission” might be
openaire   +2 more sources

Gründung eines Heimatvereins in Londorf [PDF]

, 2007
Recent cases of successful control of human immunodeficiency virus (HIV) by bone marrow transplant in combination with suppressive antiretroviral therapy (ART) and very early initiation of ART have provided proof of concept that HIV infection might now ...
Badley, AD, Lewin, SR, Sainski, A, Wightman, F   +3 more
core   +2 more sources

HIV – Is a cure possible?

Indian Journal of Sexually Transmitted Diseases and AIDS, 2019
HIV is a chronic well manageable disease. Highly active antiretroviral therapy improves the quality of life of people living with HIV, but the treatment has to be continued lifelong, as the total cure has not been established. Cost of treatment, drug toxicities, interaction with other drugs and persistence of inflammation and acceleration of the aging ...
openaire   +3 more sources

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. [PDF]

, 2018
HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs) can activate HIV expression in latently infected cells, potentially leading to their elimination
DeChristopher, Brian A, Hardman, Clayton T, Ho, Stephen, Loy, Brian A, Marsden, Matthew D, Navab, Sara M, Ramirez, Christina M, Schrier, Adam J, Shimizu, Akira J, Wender, Paul A, Wu, Xiaomeng, Zack, Jerome A   +11 more
core   +1 more source

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals. [PDF]

, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Bale, Michael J, Busch, Michael P, Cox, Bryan, Deeks, Steven G, Hoh, Rebecca, Kearney, Mary F, Kulpa, Deanna A, Lackman-Smith, Carol, Maldarelli, Frank, Ptak, Roger G, Stone, Mars, Subramanian, Krupa, Wiegand, Ann, Wonderlich, Elizabeth R   +13 more
core   +1 more source

Barriers for HIV Cure: The Latent Reservoir [PDF]

AIDS Research and Human Retroviruses, 2018
Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in search of vaccines and treatments to eradicate this devastating infectious disease. Progress has been made in understanding the molecular pathogenesis of this infection, which has been crucial for the development of the current therapy regimens. However,
Castro-Gonzalez, Sergio, Colomer Lluch, Marta, Serra Moreno, Ruth   +2 more
openaire   +4 more sources

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and mucosal reservoirs [PDF]

, 2015
Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation.
Bonczkowski, Pawel, de Looze, Danny, Johnson, Margaret, Kiselinova, Maja, Loes, Sabine Kinloch-de, Malatinkova, Eva, Murray, Charles, Spiegelaere, Ward De, Trypsteen, Wim, Vandekerckhove, Linos, Verhofstede, Chris, Vervisch, Karen   +11 more
core   +2 more sources

Integrating tuberculosis and HIV care in the primary care setting in South Africa. [PDF]

, 2004
BACKGROUND: In many countries including South Africa, the increasing human immunodeficiency virus (HIV) and tuberculosis (TB) epidemics have impacted significantly on already weakened public health services.
Anderson SR, Cantwell MF, Godfrey-Faussett P, Maher D, Rieder HL, World Health Organization   +5 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source