Results 21 to 30 of about 156,550 (306)
Synergies, tensions and challenges in HIV prevention, treatment and cure research: exploratory conversations with HIV experts in South Africa [PDF]
, 2016 Background: The ethical concerns associated with HIV prevention and treatment research have been widely explored in South Africa over the past 3 decades.
A Van der Straten +58 more
core +6 more sources
Nature Communications, 2021 To provide in depth characterization of HIV reservoir cells, the authors here develop a single-cell approach to simultaneously sequence TCR, integration sites and proviral genomes, called STIP-Seq, and show that the translation-competent reservoir mainly
Basiel Cole +11 more
doaj +1 more source
Progress toward curing HIV infection with hematopoietic cell transplantation. [PDF]
, 2015 HIV-1 infection afflicts more than 35 million people worldwide, according to 2014 estimates from the World Health Organization. For those individuals who have access to antiretroviral therapy, these drugs can effectively suppress, but not cure, HIV-1 ...
Armitage, Sue +15 more
core +1 more source
Understanding HIV Latency: The Road to an HIV Cure [PDF]
Annual Review of Medicine, 2015 Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected individuals. However, treatment has to be continued for life because it does not lead to the full eradication of infection. HIV persists in resting CD4+ T cells, and possibly other cell types, and can reemerge from these cells when therapy is interrupted.
Matthew S, Dahabieh +2 more
openaire +2 more sources
Current Opinion in HIV and AIDS, 2013 Interest in finding a potential 'cure' for HIV has taken on greater interest and urgency since the report of an individual who underwent allogeneic stem cell transplant from a CCR5 delta 32 homozygote donor after high-dose chemotherapy for acute myeloid leukemia.
openaire +2 more sources
Animal Models for HIV Cure Research [PDF]
Frontiers in Immunology, 2016 The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot clear the virus from the infected patient. A cure for HIV-1 is badly needed to stop both the spread of the virus in human populations and disease progression in infected ...
Policicchio, Benjamin B. +2 more
openaire +3 more sources
Viruses, 2023 Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, but a cure remains elusive. The largest barrier to a cure is the presence of a long-lived latent reservoir that persists within a heterogenous mix of cell ...
Catherine A. Lewis +2 more
doaj +1 more source
Combined approaches for HIV cure
Current Opinion in HIV and AIDS, 2013 A serious effort has begun to develop therapies that may be capable of eradicating established HIV infection in man. Because of the biological complexity of HIV infection that persists despite potent antiretroviral therapy, it is widely believed that if such therapies can be developed they will involve complex, multimodality approaches.
David M, Margolis, Daria J, Hazuda
openaire +3 more sources
Vaccines, 2022 Despite the high efficacy of the BNT162b2 vaccine in the general population, data on its immunogenicity among frail elderly individuals are limited. Recently, levels of anti-SARS-CoV-2 spike IgG antibodies and serum neutralization titers were confirmed ...
Wojciech Witkowski +10 more
doaj +1 more source
Interventions for neurocognitive dysfunction [PDF]
, 2017 Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core +2 more sources