A BAF’ling Approach to Curing HIV [PDF]
Cell Chemical Biology, 2018 Latency is the primary barrier to the development of a long-sought cure for HIV-1. In this issue of Cell Chemical Biology, Marian et al., (2018) describe the development of novel compounds targeting the BAF chromatin remodeling complex to reverse HIV latency, with the potential to provide a functional cure.
Tomar, Sakshi +2 more
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Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes [PDF]
, 2012 BACKGROUND: In Switzerland and other developed countries, the number of tuberculosis (TB) cases has been decreasing for decades, but HIV-infected patients and migrants remain risk groups.
Thomas Bodmer +63 more
core +1 more source
International AIDS Society global scientific strategy: towards an HIV cure 2016 [PDF]
, 2016 Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a global population of more than 35 million people living with HIV, there is intense interest in developing a cure for HIV infection.
Chen, Z +1 more
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Modelling tuberculosis in areas of high HIV prevalence [PDF]
, 2006 We describe a discrete event simulation model of tuberculosis (TB) and HIV disease, parameterized to describe the dual epidemics in Harare, Zimbabwe. TB and HIV are the leading causes of death from infectious disease among adults worldwide and the number
Hughe, Georgina R. +5 more
core +1 more source
Barriers to a cure for HIV in women [PDF]
Journal of the International AIDS Society, 2016 IntroductionDistinct biological factors exist that affect the natural history of HIV and the host immune response between women and men. These differences must be addressed to permit the optimal design of effective HIV eradication strategies for much of the HIV‐positive population.Methods and resultsHere, we review the literature on sex‐based ...
Gianella, Sara +3 more
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Religion and HIV in Tanzania: Influence of Religious Beliefs on HIV stigma, Disclosure, and Treatment Attitudes. [PDF]
, 2009 Religion shapes everyday beliefs and activities, but few studies have examined its associations with attitudes about HIV. This exploratory study in Tanzania probed associations between religious beliefs and HIV stigma, disclosure, and attitudes toward ...
Yvonne Yamanaka +11 more
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HIV and tuberculosis in Ho Chi Minh City, Vietnam, 1997-2002. [PDF]
, 2007 In Ho Chi Minh City, Vietnam, reporting rates for tuberculosis (TB) are rising in an emerging HIV epidemic. To describe the HIV epidemic among TB patients and quantify its impact on rates of reported TB, we performed a repeated cross-sectional survey ...
Borgdorff, Martien W +14 more
core +1 more source
Prospective interruption of therapy towards a cure for HIV (PITCH): experiences of patients on treatment interruption (TI) [PDF]
, 2020 Background: Increasingly cure trials require a treatment interruption (TI) in order to evaluate whether an intervention has worked. In order to ensure that future TI trials are designed sensitively with participants at the heart of the process, we ...
Fox, J +8 more
core +1 more source
Novel therapies/hopes for HIV cure in perinatally acquired HIV-positive adolescents. [PDF]
, 2018 PURPOSE OF REVIEW: Successful roll-out of paediatric antiretroviral therapy (ART) has led to a significant increase in survival of adolescents and young people growing up with HIV.
Thomas Joshua Pasvol +8 more
core +2 more sources
Understanding HIV Latency: The Road to an HIV Cure [PDF]
Annual Review of Medicine, 2015 Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected individuals. However, treatment has to be continued for life because it does not lead to the full eradication of infection. HIV persists in resting CD4+ T cells, and possibly other cell types, and can reemerge from these cells when therapy is interrupted.
Matthew S, Dahabieh +2 more
openaire +2 more sources