Results 41 to 50 of about 156,550 (306)

The integrated stress response signaling during the persistent HIV infection

iScience, 2023
Summary: Human immunodeficiency virus-1 (HIV) infection is a chronic disease under antiretroviral therapy (ART), during which active HIV replication is effectively suppressed.
Erica A. Mendes, Yuyang Tang, Guochun Jiang   +2 more
doaj   +1 more source

Problematising the discourse of 'Post-AIDS' [PDF]

, 2017
This paper reflects on the meanings of ‘post-AIDS’ in the Global North and Global South. I bring together a range of contemporary arguments to suggest that the notion of ‘post-AIDS’ is, at best, misplaced, not least because its starting point remains a ...
Walker, Liz
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Integrating Community-Based Interventions to Reverse the Convergent TB/HIV Epidemics in Rural South Africa. [PDF]

, 2015
The WHO recommends integrating interventions to address the devastating TB/HIV co-epidemics in South Africa, yet integration has been poorly implemented and TB/HIV control efforts need strengthening.
Brooks, Ralph P, Friedland, Gerald H, Galvani, Alison P, Gilbert, Jennifer A, Long, Elisa F, Moll, Anthony P, Shenoi, Sheela V, Townsend, Jeffrey P   +7 more
core   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Measuring the Inducible, Replication-Competent HIV Reservoir Using an Ultra-Sensitive p24 Readout, the Digital ELISA Viral Outgrowth Assay

Frontiers in Immunology, 2020
Quantifying the inducible HIV reservoir provides an estimate of the frequency of quiescent HIV-infected cells in humans as well as in animal models, and can help ascertain the efficacy of latency reversing agents (LRAs).
Erin L. Stuelke, Katherine S. James, Jennifer L. Kirchherr, Brigitte Allard, Caroline Baker, Joann D. Kuruc, Joann D. Kuruc, Cindy L. Gay, Cindy L. Gay, David M. Margolis, David M. Margolis, David M. Margolis, David M. Margolis, Nancie M. Archin, Nancie M. Archin   +14 more
doaj   +1 more source

Dasabuvir and Ombitasvir/Paritaprevir/Ritonavir with or without Ribavirin in Patients with HIV-HCV Coinfection. Real Life Interim Analysis of an Italian Multicentre Compassionate Use Program [PDF]

, 2016
Background and Aims: An HCV cure is now possible in a large proportion of HIV-HCV patient. We present real life results of a compassionate use program promoted by SIMIT (Infectious and Tropical Diseases Italian Society) of Dasabuvir and Ombitasvir ...
Andreoni, M., Angarano, G., Antinori, A., Boffa, N., Bruno, R., Cacopardo, B., Castelli, F., Cattelan, A., Chirianni, A., De Luca, A., Di Biagio, A., Di Perri, G., D’Arminio Monforte, A., Galli, M., Gentilotti, E., Giacometti, A., Gori, A., Lazzarin, A., Maggiolo, F., Mastroianni, C. M., Mussini, C., Parruti, G., Pasquazzi, C., Pennica, A., Puoti, M., Ricciardi, A., Rizzardini, G., Sarmati, L., Sighinolgi, L., Taliani, G., Teti, E., Vullo, V.   +31 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Eradication of HIV and Cure of AIDS, Now and How? [PDF]

, 2013
Recent studies have highlighted the importance of eradication of human immunodeficiency virus (HIV) and cure of acquired immunodeficiency syndrome (AIDS).
Clyde Crumpacker, Jielin Zhang
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source