Results 61 to 70 of about 58,279 (299)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Time to Engage Young People in HIV Cure Research [PDF]

, 2022
Antiretroviral treatments successfully suppress and control HIV but cannot eliminate the virus. In recent years, much research has gone into developing a cure for HIV.
Venegas, Manuel, Campbell, Chadwick K, Saberi, Parya, Campbell, Chadwick K., Dubé, Karine   +4 more
core   +1 more source

Perceptions of HIV cure research among people living with HIV in Australia [PDF]

, 2018
Participation in HIV cure-related clinical trials that involve antiretroviral treatment (ART) interruption may pose substantial individual risks for people living with HIV (PLHIV) without any therapeutic benefit.
Brown, G, Power, J., Sugarman, Jeremy, Hill, S., Brown, Graham, Tucker, JD, Richmond, J., Lewin, SR, Wallace, J., Tucker, Joseph D, Hill, S, Gary W Dowsett, Sugarman, J., Westle, A, Jayne Lucke, Sharon R Lewin, Jacqui Richmond, Westle, Andrew, Westle, A., Power, J, Dowsett, Gary W., Tucker, Joseph D., Lucke, Jayne, Graham Brown, Power, Jennifer, Jeremy Sugarman, Lewin, Sharon R., Sophie Hill, Jack Wallace, Hill, Sophie, Andrew Westle, Joseph D Tucker, Lewin, Sharon R, Wallace, Jack, Tucker, J., Lewin, S., Dowsett, GW, Dowsett, Gary W, Lucke, J., Sugarman, J, Richmond, Jacqui, Dowsett, G., Jennifer Power, Lucke, J, Wallace, J, Richmond, J   +45 more
core   +5 more sources

Searching for a HIV-1 Cure

Theranostics
Advances in stem cell transplantation, broadly neutralizing antibodies, ultra-long-acting antiretroviral drugs, therapeutic vaccines, cell engineering, gene therapy, and immune-based molecular therapies have highlighted efforts to cure human immunodeficiency virus type 1 (HIV-1). However, none of these are durable.
Zhang, Chen, Chaudhary, Bharat N., Ali, Mohammad Uzair, Heser, Mary G., Patel, Swara S., Du, Xiaoqing, Dey, Soumya S., Mosley, R. Lee, Panja, Sudipta, Gendelman, Howard E.   +9 more
openaire   +3 more sources

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

The significance and expectations of HIV cure research among people living with HIV in Australia [PDF]

, 2020
Most people living with HIV (PLHIV) with reliable access to antiretroviral treatment (ART) have a life expectancy similar to uninfected populations. Despite this, HIV can negatively affect their social and psychological wellbeing.
Brown, G, Sugarman, Jeremy, Brown, Graham, Tucker, JD, Lewin, SR, Tucker, Joseph D, Hill, S, Gary W Dowsett, Westle, A, Sharon R Lewin, Jayne Lucke, Westle, Andrew, Power, J, Dowsett, Gary W., Tucker, Joseph D., Lucke, Jayne, Graham Brown, Power, Jennifer, Jeremy Sugarman, Lewin, Sharon R., Sophie Hill, Hill, Sophie, Andrew Westle, Joseph D Tucker, Lewin, Sharon R, Dowsett, GW, Dowsett, Gary W, Sugarman, J, Jennifer Power, Lucke, J   +29 more
core   +1 more source

HIV Latency in Myeloid Cells: Challenges for a Cure [PDF]

, 2022
The use of antiretroviral therapy (ART) for Human Immunodeficiency Virus (HIV) treatment has been highly successful in controlling plasma viremia to undetectable levels.
Soriano-Sarabia, Natalia, Marta Sanz, Chitrakar, Alisha, Sanz, Marta, Natalia Soriano-Sarabia, Sanjay B. Maggirwar, Maggirwar, Sanjay B., Alisha Chitrakar   +7 more
core   +1 more source

Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1: a Phase IIa randomised controlled study

Journal of Virus Eradication, 2019
Objectives: To assess the safety and tolerability as well as antiretroviral impact of ABX464, an oral investigational drug with a novel mechanism of HIV-1 inhibition (ClinicalTrials.gov NCT02735863). Methods: Randomised, double-blind, placebo-controlled,
Sofie Rutsaert, Jean-Marc Steens, Paul Gineste, Basiel Cole, Sam Kint, P. Noel Barrett, Jamal Tazi, Didier Scherrer, Hartmut J. Ehrlich, Linos Vandekerckhove   +9 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source