Results 51 to 60 of about 58,279 (299)

Highlights from the HIV Cure and Reservoir Symposium, 11–12 September 2017, Ghent, Belgium

Journal of Virus Eradication, 2018
For the second time, the HIV Cure Research Center (HCRC) at Ghent University organised the HIV Cure and Reservoir Symposium, in Ghent, Belgium, where in this two-day conference, virologists, molecular biologists, immunologists and clinicians presented ...
Sam Kint, Clarissa Van Hecke, Basiel Cole, Linos Vandekerckhove, Magdalena Sips   +4 more
doaj   +1 more source

The integrated stress response signaling during the persistent HIV infection

iScience, 2023
Summary: Human immunodeficiency virus-1 (HIV) infection is a chronic disease under antiretroviral therapy (ART), during which active HIV replication is effectively suppressed.
Erica A. Mendes, Yuyang Tang, Guochun Jiang   +2 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Model-based evaluation of the impact of a potential HIV cure on HIV transmission dynamics. [PDF]

Nat Commun
The development of an HIV cure is a global health priority, with the target product profile (TPP) for an HIV cure guiding research efforts. Using a mathematical model calibrated to data from men who have sex with men (MSM) in the Netherlands, we assessed
De Bellis A, Willemsen MS, Guzzetta G, van Sighem A, Romijnders KAGJ, Reiss P, Schim van der Loeff MF, van de Wijgert JHHM, Nijhuis M, Kretzschmar MEE, Rozhnova G.   +10 more
europepmc   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Measuring the Inducible, Replication-Competent HIV Reservoir Using an Ultra-Sensitive p24 Readout, the Digital ELISA Viral Outgrowth Assay

Frontiers in Immunology, 2020
Quantifying the inducible HIV reservoir provides an estimate of the frequency of quiescent HIV-infected cells in humans as well as in animal models, and can help ascertain the efficacy of latency reversing agents (LRAs).
Erin L. Stuelke, Katherine S. James, Jennifer L. Kirchherr, Brigitte Allard, Caroline Baker, Joann D. Kuruc, Joann D. Kuruc, Cindy L. Gay, Cindy L. Gay, David M. Margolis, David M. Margolis, David M. Margolis, David M. Margolis, Nancie M. Archin, Nancie M. Archin   +14 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Implications of prioritizing HIV cure: new momentum to overcome old challenges in HIV. [PDF]

, 2016
BACKGROUND: Curing HIV is a new strategic priority for several major AIDS organizations. In step with this new priority, HIV cure research and related programs are advancing in low, middle, and high-income country settings.
Gilbertson, Adam, Tucker, Joseph, Marco Vitória, Lo, Ying-Ru, Vitória, Marco, Joseph D. Tucker, Adam Gilbertson, Ying-Ru Lo, Tucker, Joseph D   +8 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A Plausible Link of TMPRSS2/ACE2/AR Signaling to Male Mortality during the COVID-19 Pandemic in the United States

Pathogens, 2021
The COVID-19 pandemic continues around the world, where the United States is among the worst in terms of both morbidity and fatality of the viral infection.
Lilly M. Wong, Guochun Jiang
doaj   +1 more source